Reduced spontaneous but relatively normal deliberate vicarious representations in psychopathy

Brain

Volumn 136, Issue 8, 2013, Pages 2550-2562

  Meffert, Harma ^a,b,c,e   Gazzola, Valeria ^a,c   Den Boer, Johan A ^a   Bartels, Arnold A J ^d   Keysers, Christian ^a,c  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b Research Department of Forensic Psychiatric Center Dr S van Mesdag   (Netherlands)

^c NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^d Amsterdam Clinic   (Netherlands)

^e NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Empathy; Functional MRI; Psychopathy; Vicarious responses

Indexed keywords

ADULT; ARTICLE; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; FEMALE; HAND MOVEMENT; HUMAN; MALE; PRIORITY JOURNAL; PSYCHOPATHY; VIDEORECORDING;

EID: 84880951749     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awt190     Document Type: Article

References (77)

1. Adolphs R. What does the amygdala contribute to social cognition? Ann N Y Acad Sci 2010; 1191: 42-61.
2. Amodio DM, Frith CD. Meeting of minds: the medial frontal cortex and social cognition. Nat Rev Neurosci 2006; 7: 268-77.
3. Amunts K, Kedo O, Kindler M, Pieperhoff P, Mohlberg H, Shah NJ, et al. Cytoarchitectonic mapping of the human amygdala, hippocampal region and entorhinal cortex: intersubject variability and probability maps. Anat Embryol 2005; 210: 343-352.
4. Aniskiewicz AS. Autonomic components of vicarious conditioning and psychopathy. J Clin Psychol 1979; 35: 60-7.
5. Bastiaansen JA, Thioux M, Keysers C. Evidence for mirror systems in emotions. Philos Trans R Soc London B Biol Sci 2009; 364: 2391-404.
6. Birbaumer N, Veit R, Lotze M, Erb M, Hermann C, Grodd W, et al. Deficient fear conditioning in psychopathy: a functional magnetic resonance imaging study. Arch Gen Psychiatry 2005; 62: 799-805.
7. Blair J, Sellars C, Strickland I, Clark F, Williams A, Smith M, et al. Theory of Mind in the psychopath. J Forens Psychiatry Psychol 1996; 7: 15-25.
8. Blair RJ. The amygdala and ventromedial prefrontal cortex in morality and psychopathy. Trends Cogn Sci 2007; 11: 387-92.
9. Blair RJ, Jones L, Clark F, Smith M. The psychopathic individual: a lack of responsiveness to distress cues? Psychophysiology 1997; 34: 192-8.
10. Blair RJ, Mitchell DGV, Peschardt KS, Colledge E, Leonard RA, Shine JH, et al. Reduced sensitivity to others' fearful expressions in psychopathic individuals. Pers Individ Diff 2004; 37: 1111-22.
11. Blair RJ, Mitchell DGV, Richell RA, Kelly S, Leonard A, Newman C, et al. Turning a deaf ear to fear: Impaired recognition of vocal affect in psychopathic individuals. J Abnorm Psychol 2002; 111: 682-6.
12. Blair RJ, Peschardt KS, Budhani S, Mitchell DGV, Pine DS. The development of psychopathy. J Child Psychol Psychiatry 2006; 47: 262-76.
13. Blair RJ, Sellars C, Strickland I, Clark F, Williams AO, Smith M, et al. Emotion attributions in the psychopath. Pers and Individ Diff 1995; 19: 431-7.
14. Caruana F, Jezzini A, Sbriscia-Fioretti B, Rizzolatti G, Gallese V. Emotional and social behaviors elicited by electrical stimulation of the insula in the macaque monkey. Curr Biol 2011; 21: 195-9.
15. Caspers S, Eickhoff SB, Geyer S, Scheperjans F, Mohlberg H, Zilles K, et al. The human inferior parietal lobule in stereotaxic space. Brain Struct Funct 2008; 212: 481-95.
16. Caspers S, Geyer S, Schleicher A, Mohlberg H, Amunts K, Zilles K. The human inferior parietal cortex: cytoarchitectonic parcellation and interindividual variability. Neuroimage 2006; 33: 430-48.
17. Caspers S, Zilles K, Laird AR, Eickhoff SB. ALE meta-analysis of action observation and imitation in the human brain. Neuroimage 2010; 50: 1148-67.
18. Cheng Y, Hung AY, Decety J. Dissociation between affective sharing and emotion understanding in juvenile psychopaths. Dev Psychopathol 2012; 24: 623-36.
19. Choi H-J, Zilles K, Mohlberg H, Schleicher A, Fink GR, Armstrong E, et al. Cytoarchitectonic identification and probabilistic mapping of two distinct areas within the anterior ventral bank of the human intraparietal sulcus. J Comp Neurol 2006; 495: 53-69.
20. Cornell DG, Warren J, Hawk G, Stafford E, Oram G, Pine D. Psychopathy in instrumental and reactive violent offenders. J Consult Clin Psychol 1996; 64: 783-90.
21. Dapretto M, Davies MS, Pfeifer JH, Scott AA, Sigman M, Bookheimer SY, et al. Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders. Nat Neurosci 2006; 9: 28-30.
22. de Oliveira-Souza R, Hare RD, Bramati IE, Garrido GJ, Azevedo Ignácio F, Tovar-Moll F, et al. Psychopathy as a disorder of the moral brain: fronto-temporo-limbic grey matter reductions demonstrated by voxelbased morphometry. Neuroimage 2008; 40: 1202-13.
23. de Vignemont F, Singer T. The empathic brain: how, when and why? Trends Cogn Sci 2006; 10: 435-41.
24. Decety J, Moriguchi Y. The empathic brain and its dysfunction in psychiatric populations: implications for intervention across different clinical conditions. Bio Psycho Social Medicine 2007; 1: 22.
25. Deeley Q, Daly E, Surguladze S, Tunstall N, Mezey G, Beer D, et al. Facial emotion processing in criminal psychopathy: Preliminary functional magnetic resonance imaging study. Br J Psychiatry 2006; 189: 533-9.
26. Dinstein I, Thomas C, Behrmann M, Heeger DJ. A mirror up to nature. Curr Biol 2008; 18: R13-8.
27. Dolan M, Fullam R. Theory of mind and mentalizing ability in antisocial personality disorders with and without psychopathy. Psychol Med 2004; 34: 1093-102.
28. Dolan M, Fullam R. Face affect recognition deficits in personality-disordered offenders: association with psychopathy. Psychol Med 2006; 36: 1563-9.
29. Eickhoff SB, Paus T, Caspers S, Grosbras MH, Evans AC, Zilles K, et al. Assignment of functional activations to probabilistic cytoarchitectonic areas revisited. Neuroimage 2007; 36: 511-21.
30. Gazzola V, Aziz-Zadeh L, Keysers C. Empathy and the somatotopic auditory mirror system in humans. Curr Biol 2006; 16: 1824-9.
31. Gazzola V, Keysers C. The observation and execution of actions share motor and somatosensory voxels in all tested subjects: singlesubject analyses of unsmoothed fMRI data. Cereb Cortex 2009; 19: 1239-55.
32. Hare RD. The Hare psychopathy checklist-revised. Toronto: Multi-Health Systems; 1991.
33. Hare RD. Manual for the Revised Psychopathy Checklist. 2nd edn. Toronto: Multi-Health Systems; 2003.
34. Hare RD, Neumann CS. Psychopathy: Assessment and forensic implications. Can J Psychiatry 2009; 54: 791-802.
35. Hare RD, Vertommen H, Brink WVD, Ruiter CD. De Psychopathie Checklist revised. Handleiding. Lisse: Swets & Zeitlinger; 2001.
36. Harenski CL, Harenski KA, Shane MS, Kiehl KA. Aberrant neural processing of moral violations in criminal psychopaths. J Abnorm Psychol 2010; 119: 863-74.
37. Hastings ME, Tangney JP, Stuewig J. Psychopathy and identification of facial expressions of emotion. Pers Individ Diff 2008; 44: 1474-83.
38. Iacoboni M. Failure to deactivate in autism: the co-constitution of self and other. Trends Cogn Sci 2006; 10: 431-3.
39. Jabbi M, Bastiaansen JA, Keysers C. A common anterior insula representation of disgust observation, experience and imagination shows divergent functional connectivity pathways. PLoS One 2008; 3: 8.
40. Jabbi M, Swart M, Keysers C. Empathy for positive and negative emotions in the gustatory cortex. Neuroimage 2007; 34: 1744-53.
41. Keysers C, Gazzola V. Expanding the mirror: vicarious activity for actions, emotions, and sensations. Cur Opin Neurobiol 2009; 19: 666-71.
42. Keysers C, Kaas JH, Gazzola V. Somatosensation in social perception. Nat Rev Neurosci 2010; 11: 417-28.
43. Kiehl KA, Smith AM, Hare RD, Mendrek A, Forster BB, Brink J, et al. Limbic abnormalities in affective processing by criminal psychopaths as revealed by functional magnetic resonance imaging. Biol Psychiatry 2001; 50: 677-84.
44. Kosson DS, Suchy Y, Mayer AR, Libby J. Facial affect recognition in criminal psychopaths. Emotion 2002; 2: 398-411.
45. Lamm C, Decety J, Singer T. Meta-analytic evidence for common and distinct neural networks associated with directly experienced pain and empathy for pain. Neuroimage 2011; 54: 2492-502.
46. Lilienfeld SO, Andrews BP. Development and preliminary validation of a self-report measure of psychopathic personality traits in noncriminal population. J Pers Assessment 1996; 66: 488.
47. Lord C, Rutter M, DiLavore PC, Risi S. Autism diagnostic observation schedule. Manual. Los Angeles, CA: Western Psychological Services; 1999.
48. Luteijn F, Barelds DPF. GIT 2: Groninger intelligentie test 2. Harcourt; 2004.
49. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage 2003; 19: 1233-9.
50. Marsh AA, Finger EC, Mitchell DGV, Reid ME, Sims C, Kosson DS, et al. Reduced amygdala response to fearful expressions in children and adolescents with callous-unemotional traits and disruptive behavior disorders. Am J Psychiatry 2008; 165: 712-20.
51. Miller GA, Chapman JP. Misunderstanding analysis of covariance. J Abnorm Psychol 2001; 110: 40-8.
52. Miller PA, Eisenberg N. The relation of empathy to aggressive and externalizing/antisocial behavior. Psychol Bull 1988; 103: 324-44.
53. Minio-Paluello I, Baron-Cohen S, Avenanti A, Walsh V, Aglioti SM. Absence of embodied empathy during pain observation in asperger syndrome. Biol Psychiatry 2009; 65: 55-62.
54. Moul C, Killcross S, Dadds MR. A model of differential amygdala activation in psychopathy. Psychol Rev 2012; 119: 789-806.
55. Müller JL, Gänssbauer S, Sommer M, Döhnel K, Weber T, Schmidt-Wilcke T, et al. Gray matter changes in right superior temporal gyrus in criminal psychopaths. Evidence from voxel-based morphometry. Psychiatry Res 2008; 163: 213-22.
56. Müller JL, Sommer M, Wagner V, Lange K, Taschler H, Röder CH, et al. Abnormalities in emotion processing within cortical and subcortical regions in criminal psychopaths: Evidence from a functional magnetic resonance imaging study using pictures with emotional content. Biol Psychiatry 2003; 54: 152-62.
57. Newman JP, Curtin JJ, Bertsch JD, Baskin-Sommers AR. Attention moderates the fearlessness of psychopathic offenders. Biol Psychiatry 2010; 67: 66-70.
58. Ochsner KN, Ray RD, Cooper JC, Robertson ER, Chopra S, Gabrieli JDE, et al. For better or for worse: neural systems supporting the cognitive down-and up-regulation of negative emotion. Neuroimage 2004; 23: 483-99.
59. Patrick CJ, Zempolich KA. Emotion and aggression in the psychopathic personality. Aggression Violent Behav 1998; 3: 303-38.
60. Patterson CM, Newman JP. Reflectivity and learning from aversive events: Toward a psychological mechanism for the syndromes of disinhibition. Psychol Rev 1993; 100: 716-36.
61. Perkins T, Stokes M, McGillivray J, Bittar R. Mirror neuron dysfunction in autism spectrum disorders. J Clin Neurosci 2010; 17: 1239-43.
62. Pineda JA. Sensorimotor cortex as a critical component of an 'extended' mirror neuron system: does it solve the development, correspondence, and control problems in mirroring? Behav and Brain Funct 2008; 4: 47.
63. Raven J, Raven JC, Court JH. Manual for Raven's Progressive Matrices and Vocabulary Scales. Section 1: General Overview. San Antonio: TX: Harcourt Assessment; 2003.
64. Richell RA, Mitchell DGV, Newman C, Leonard A, Baron-Cohen S, Blair RJR. Theory of mind and psychopathy: can psychopathic individuals read the 'language of the eyes'? Neuropsychologia 2003; 41: 523-6.
65. Salekin RT, Worley C, Grimes RD. Treatment of psychopathy: a review and brief introduction to the mental model approach for psychopathy. Behav Sci Law 2010; 28: 235-66.
66. Scheperjans F, Eickhoff SB, Hömke L, Mohlberg H, Hermann K, Amunts K, et al. Probabilistic Maps, Morphometry, and Variability of Cytoarchitectonic Areas in the Human Superior Parietal Cortex. Cereb Cortex 2008b; 18: 2141-57.
67. Scheperjans F, Hermann K, Eickhoff SB, Amunts K, Schleicher A, Zilles K, et al. Observer-independent cytoarchitectonic mapping of the human superior parietal cortex. Cereb Cortex 2008a; 18: 846-67.
68. Schiffer B, Müller BW, Scherbaum N, Hodgins S, Forsting M, Wiltfang J, et al. Disentangling structural brain alterations associated with violent behavior from those associated with substance use disorders. Arch Gen Psychiatry 2011; 68: 1039-49.
69. Serin RC. Psychopathy and violence in criminals. J Interpers Violence 1991; 6: 423-31.
70. Singer T, Seymour B, O'Doherty J, Kaube H, Dolan RJ, Frith CD. Empathy for pain involves the affective but not sensory components of pain. Science 2004; 303: 1157-62.
71. Singer T, Seymour B, O'Doherty JP, Stephan KE, Dolan RJ, Frith CD. Empathic neural responses are modulated by the perceived fairness of others. Nature 2006; 439: 466-9.
72. Sommer M, Sodian B, Döhnel K, Schwerdtner J, Meinhardt J, Hajak G. In psychopathic patients emotion attribution modulates activity in outcome-related brain areas. Psychiatry Res Neuroimag 2010; 182: 88-95.
73. Tiihonen J, Rossi R, Laakso MP, Hodgins S, Testa C, Perez J, et al. Brain anatomy of persistent violent offenders: more rather than less. Psychiatry Res 2008; 163: 201-12.
74. Van Overwalle F, Baetens K. Understanding others' actions and goals by mirror and mentalizing systems: a meta-analysis. Neuroimage 2009; 48: 564-84.
75. Wicker B, Keysers C, Plailly J, Royet JP, Gallese V, Rizzolatti G. Both of us disgusted in My insula: The common neural basis of seeing and feeling disgust. Neuron 2003; 40: 655-64.
76. Williamson S, Hare RD, Wong S. Violence-Criminal Psychopaths and Their Victims. Can J Behav Sci 1987; 19: 454-62.
77. Yang Y, Raine A, Colletti P, Toga AW, Narr KL. Abnormal temporal and prefrontal cortical gray matter thinning in psychopaths. Mol Psychiatry 2009; 14: 561-2.