Candida albicans and Candida parapsilosis induce different T-cell responses in human peripheral blood mononuclear cells

Journal of Infectious Diseases

Volumn 208, Issue 4, 2013, Pages 690-698

  Tóth, Adél ^a   Csonka, Katalin ^a   Jacobs, Cor ^b   Vágvölgyi, Csaba ^a   Nosanchuk, Joshua D ^c   Netea, Mihai G ^b   Gácser, Attila ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Candida parapsilosis; Human PBMC; T cell response

Indexed keywords

DECTIN 1; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 22; INTERLEUKIN 6; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN RECOGNITION; ARTICLE; CANDIDA ALBICANS; CANDIDA PARAPSILOSIS; CELL STIMULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME INHIBITION; HELPER CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; TH17 CELL;

CANDIDA PARAPSILOSIS; HUMAN PBMC; T CELL RESPONSE;

CANDIDA; CANDIDEMIA; CYTOKINES; HUMANS; LECTINS, C-TYPE; LEUKOCYTES, MONONUCLEAR; MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84880947536     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit188     Document Type: Article

References (21)

1. Pfaller MA, Diekema DJ. Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev 2007; 20:133-63.
2. Pfaller MA, Diekema DJ, Gibbs DL, et al. Results from the ARTEMIS DISK Global Antifungal Surveillance Study, 1997 to 2007: a 10.5-year analysis of susceptibilities of Candida Species to fluconazole and voriconazole as determined by CLSI standardized disk diffusion. J Clin Microbiol 2010; 48:1366-77.
3. Trofa D, Gacser A, Nosanchuk JD. Candida parapsilosis, an emerging fungal pathogen. Clin Microbiol Rev 2008; 21:606-25.
4. Dotis J, Prasad PA, Zaoutis T, Roilides E. Epidemiology, risk factors and outcome of Candida parapsilosis bloodstream infection in children. Pediatr Infect Dis J 2012; 31:557-60.
5. Hernandez-Santos N, Gaffen SL. Th17 cells in immunity to Candida albicans. Cell Host Microbe 2012; 11:425-35.
6. Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005; 6:1123-32.
7. Ouyang W, Kolls JK, Zheng Y. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 2008; 28:454-67.
8. Huang W, Na L, Fidel PL, Schwarzenberger P. Requirement of interleukin- 17A for systemic anti-Candida albicans host defense in mice. J Infect Dis 2004; 190:624-31.
9. Puel A, Cypowyj S, Bustamante J, et al. Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science 2011; 332:65-8.
10. van de Veerdonk FL, Plantinga TS, Hoischen A, et al. STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis. N Engl J Med 2011; 365:54-61.
11. Liu L, Okada S, Kong XF, et al. Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis. J Exp Med 2011; 208:1635-48.
12. Netea MG, Gow NA, Munro CA, et al. Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. J Clin Invest 2006; 116: 1642-50.
13. van de Veerdonk FL, Netea MG. T-cell subsets and antifungal host defenses. Curr Fungal Infect Rep 2010; 4:238-43.
14. Kerrigan AM, Brown GD. Syk-coupled C-type lectins in immunity. Trends Immunol 2011; 32:151-6.
15. Netea MG, Brown GD, Kullberg BJ, Gow NA. An integrated model of the recognition of Candida albicans by the innate immune system. Nat Rev Microbiol 2008; 6:67-78.
16. Kawai T, Akira S. TLR signaling. Cell Death Differ 2006; 13:816-25.
17. Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 2007; 8:942-9.
18. Annunziato F, Cosmi L, Santarlasci V, et al. Phenotypic and functional features of human Th17 cells. J Exp Med 2007; 204:1849-61.
19. Armstrong-James D, Teo IA, Shrivastava S, et al. Exogenous interferongamma immunotherapy for invasive fungal infections in kidney transplant patients. Am J Transplant 2010; 10:1796-803.
20. van de Veerdonk FL, Kullberg BJ, Netea MG. Adjunctive immunotherapy with recombinant cytokines for the treatment of disseminated candidiasis. Clin Microbiol Infect 2012; 18:112-9.
21. Gacser A, Salomon S, Schafer W. Direct transformation of a clinical isolate of Candida parapsilosis using a dominant selection marker. FEMS Microbiol Lett 2005; 245:117-21.