Alternative monotherapy or add-on therapy in patients with epilepsy whose seizures do not respond to the first monotherapy: An Italian multicenter prospective observational study

Epilepsy and Behavior

Volumn 28, Issue 3, 2013, Pages 494-500

  Millul, Andrea ^a   Iudice, Alfonso ^b   Adami, Marina ^c   Porzio, Roberto ^c   Mattana, Flavia ^a   Beghi, Ettore ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c Janssen Cilag SpA Italia   (Italy)

Author keywords

Cohort study; Epilepsy; Monotherapy; Polytherapy

Indexed keywords

BARBEXACLONE; CARBAMAZEPINE; CLOBAZAM; CLONAZEPAM; ETHOSUXIMIDE; ETIRACETAM; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PREGABALIN; TOPIRAMATE; VALPROIC ACID;

ADD ON THERAPY; ADOLESCENT; ADULT; AGED; ARTICLE; BREAST DISEASE; CHILD; CLINICAL ASSESSMENT; CONNECTIVE TISSUE DISEASE; COST; DRUG WITHDRAWAL; ENDOCRINE DISEASE; EPILEPSY; FEMALE; GASTROINTESTINAL SYMPTOM; HEMATOLOGIC DISEASE; HEPATOBILIARY DISEASE; HOSPITAL ADMISSION; HUMAN; INJECTION SITE REACTION; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; METABOLIC DISORDER; MONOTHERAPY; MULTICENTER STUDY; MUSCULOSKELETAL DISEASE; NEUROLOGIC DISEASE; OBSERVATIONAL STUDY; PRESCHOOL CHILD; PROSPECTIVE STUDY; QUALITY OF LIFE; REMISSION; SCHOOL CHILD; SEIZURE; SKIN DISEASE; TREATMENT DURATION; TREATMENT FAILURE; TREATMENT INDICATION;

COHORT STUDY; EPILEPSY; MONOTHERAPY; POLYTHERAPY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTICONVULSANTS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DRUG THERAPY, COMBINATION; EPILEPSY; FEMALE; HUMANS; ITALY; MALE; MIDDLE AGED; TIME FACTORS; YOUNG ADULT;

EID: 84880941008     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2013.05.038     Document Type: Article

References (20)

1. Annegers J.F., Hauser W.A., Elveback L.R. Remission of seizures and relapse in patients with epilepsy. Epilepsia 1979, 20:729-737.
2. Cockerell O.C., Johnson A.L., Sander J.W., Hart Y.M., Shorvon S.D. Remission of epilepsy: results from the National General Practice Study of Epilepsy. Lancet 1995, 346:140-144.
3. Prognosis of epilepsy in newly referred patients: a multicenter prospective study of the effects of monotherapy on the long-term course of epilepsy. Epilepsia 1992, 33:45-51. Collaborative Group for the Study of Epilepsy.
4. Kwan P., Brodie M.J. Early identification of refractory epilepsy. N Engl J Med 2000, 342:314-319.
5. Deckers C.L.P., Genton P., Sills G.J., Schmidt D. Current limitations of antiepileptic drug therapy: a conference review. Epilepsy Res 2003, 53:1-17.
6. Beghi E., Gatti G., Tonini C., ben-Menachem E., Chadwick D.W., Nikanorova M., et al. Adjunctive therapy versus alternative monotherapy in patients with partial epilepsy failing on a single drug: a multicentre, randomized, pragmatic controlled trial. Epilepsy Res 2003, 57:1-13.
7. Baldy-Moulinier M., Covanis A., D'Urso S., Eskazan E., Fattore C., Gatti G., et al. Therapeutic strategies against epilepsy in Mediterranean countries: a report from an international collaborative survey. Seizure 1998, 7:513-520.
8. Karceski S., Morrell M.J., Carpenter D. Treatment of epilepsy in adults: expert opinion, 2005. Epilepsy Behav 2005, 7:S1-S64.
9. Kwan P., Brodie M.J. Drug treatment of epilepsy: when does it fail and how to optimize its use?. CNS Spectr 2004, 9:110-119.
10. Brodie M.J., Kwan P. Staged approach to epilepsy management. Neurology 2002, 58(Suppl. 5):S2-S8.
11. Commission on Epidemiology and Prognosis, International League Against Epilepsy Guidelines for epidemiologic studies on epilepsy. Epilepsia 1993, 34:592-596.
12. Commission on Classification and Terminology of the International League Against Epilepsy Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia 1981, 22:489-501.
13. Commission on Classification and Terminology of the International League Against Epilepsy Proposal for revised classification of epilepsies and epileptic syndrome. Epilepsia 1989, 30:389-399.
14. Medical dictionary for regulatory activities. Version 14.0 2011, Northrop Grumman Corporation.
15. Beghi E., Niero M., Roncolato M. Validity and reliability of the Italian version of the Quality-of-Life in Epilepsy Inventory (QOLIE-31). Seizure 2005, 14:452-458.
16. Beghi E., Perucca E. The management of epilepsy in the 1990s: acquisitions, uncertainties, and perspectives for future research. Drugs 1995, 49:680-694.
17. National Institute for Clinical Excellence Newer drugs for epilepsy in adults [accessed Aug 31, 2004]. http://www.nice.org.uk/Docref.asp?d=110081.
18. National Institute for Clinical Excellence Newer drugs for epilepsy in children [accessed Aug 31, 2004]. http://www.nice.org.uk/Docref.asp?d=113359.
19. Scottish Intercollegiate Guidelines Network Diagnosis and management of epilepsy [accessed July 31, 2004]. http://www.sign.ac.uk/pdf/sign70.pdf.
20. Deckers C.L.P., Hekster Y.A., Keyser A., van Lier H.J.J., Meinardi H., Renier W.O. Monotherapy versus polytherapy for epilepsy: a multicenter double-blind randomized study. Epilepsia 2001, 42:1387-1394.