Functional characterisation of a metagenome derived family VIII esterase with a deacetylation activity on β-lactam antibiotics

Biochemical and Biophysical Research Communications

Volumn 437, Issue 3, 2013, Pages 342-348

  Mokoena, Nobalanda ^a   Mathiba, Kgama ^a   Tsekoa, Tsepo ^a   Steenkamp, Paul ^a,b   Rashamuse, Konanani ^a  

^a DSI CSIR Nanotechnology Innovation Centre   (South Africa)

^b UNIVERSITY OF JOHANNESBURG   (South Africa)

Author keywords

Lactam substrate; Family VIII carboxylesterase; Functional metagenomics

Indexed keywords

BETA LACTAM; BETA LACTAMASE; CARBOXYLESTERASE; CEPHALOSPORIN; ESTERASE; ESTERASE 22; NITROCEFIN; PEPTIDASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVITY; ENZYME SPECIFICITY; LEACHING; METAGENOME; PHYLOGENY; PRIORITY JOURNAL;

Β-LACTAM SUBSTRATE; FAMILY VIII CARBOXYLESTERASE; FUNCTIONAL METAGENOMICS;

ACETYLATION; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BASE SEQUENCE; BETA-LACTAMASES; BETA-LACTAMS; CARBOXYLIC ESTER HYDROLASES; GENE LIBRARY; GENES, BACTERIAL; METAGENOME; MOLECULAR SEQUENCE DATA; RANDOM ALLOCATION; SUBSTRATE SPECIFICITY;

EID: 84880936917     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.06.076     Document Type: Article

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