Dose-dependent diastolic dysfunction and early death in a mouse model with cardiac troponin mutations

Journal of Molecular and Cellular Cardiology

Volumn 62, Issue , 2013, Pages 227-236

  Li, Yuejin ^a   Zhang, Lei ^b   Jean Charles, Pierre Yves ^a   Nan, Changlong ^a   Chen, Guozhen ^b   Tian, Jie ^b   Jin, J P ^c   Gelb, Ira J ^a   Huang, Xupei ^a,b  

^a FLORIDA ATLANTIC UNIVERSITY   (United States)

^b CHONGQING MEDICAL UNIVERSITY   (China)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiomyopathy; Diastolic dysfunction; Dose dependent; Heart failure; Mutation; Thin filament

Indexed keywords

CALCIUM ION; MUTANT PROTEIN; TROPONIN I;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DEATH; DIASTOLIC DYSFUNCTION; ECHOCARDIOGRAPHY; HEART ATRIUM ENLARGEMENT; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART MUSCLE ISCHEMIA; HEART MUSCLE RELAXATION; HEART VENTRICLE ENDDIASTOLIC PRESSURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESTRICTIVE CARDIOMYOPATHY; ST SEGMENT DEPRESSION; SYSTOLIC DYSFUNCTION; SYSTOLIC HEART FAILURE; TRANSGENIC MOUSE;

CARDIOMYOPATHY; DIASTOLIC DYSFUNCTION; DOSE-DEPENDENT; EF; EJECTION FRACTION; FRACTIONAL SHORTENING; FS; HCM; HEART FAILURE; HYPERTROPHIC CARDIOMYOPATHY; ISOVOLUMETRIC CONTRACTION TIME; ISOVOLUMETRIC RELAXATION TIME; IVCT; IVRT; LEFT VENTRICLE END DIASTOLE DIMENSION; LEFT VENTRICLE END DIASTOLE VOLUME; LVEDD; LVEDV; MUTATION; RCM; RESTRICTIVE CARDIOMYOPATHY; TG; THIN FILAMENT; TNI; TRANSGENIC; TROPONIN I;

ANIMALS; BLOTTING, WESTERN; CALCIUM; CARDIOMYOPATHIES; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; MYOCYTES, CARDIAC; TROPONIN I;

EID: 84880936561     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2013.06.007     Document Type: Article

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