Evaluation of SF-1 expression in testicular germ cell tumors: A tissue microarray study of 127 cases

Applied Immunohistochemistry and Molecular Morphology

Volumn 21, Issue 4, 2013, Pages 318-321

  Sangoi, Ankur R ^a,b   McKenney, Jesse K ^a   Brooks, James D ^a   Higgins, John P ^a  

^a STANFORD UNIVERSITY   (United States)

^b EL CAMINO HOSPITAL   (United States)

Author keywords

germ cell tumor; immunohistochemistry; Leydig; Sertoli; sexcord stromal; SF 1

Indexed keywords

STEROIDOGENIC FACTOR 1;

ARTICLE; CHORIOCARCINOMA; CONTROLLED STUDY; EMBRYONAL CARCINOMA; EPIDERMOID CYST; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LEYDIG CELL; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEMINOMA; SERTOLI CELL; STROMA; TERATOMA; TISSUE MICROARRAY;

GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; NEOPLASMS, GERM CELL AND EMBRYONAL; STEROIDOGENIC FACTOR 1; TESTICULAR NEOPLASMS; TISSUE ARRAY ANALYSIS;

EID: 84880923931     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/PAI.0b013e318277cf5a     Document Type: Article

References (20)

1. Hopps CV, Goldstein M. Ultrasound guided needle localization and microsurgical exploration for incidental nonpalpable testicular tumors. J Urol. 2002;168:1084-1087.
2. Cao D, Li J, Guo CC, et al. SALL4 is a novel diagnostic marker for testicular germ cell tumors. Am J Surg Pathol. 2009;33: 1065-1077.
3. Kononen J, Bubendorf L, Kallioniemi A, et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med. 1998;4:844-847.
4. Henley JD, Young RH, Ulbright TM. Malignant Sertoli cell tumors of the testis: A study of 13 examples of a neoplasm frequently misinterpreted as seminoma. Am J Surg Pathol. 2002;26: 541-550.
5. Young RH, Koelliker DD, Scully RE. Sertoli cell tumors of the testis, not otherwise specified: A clinicopathologic analysis of 60 cases. Am J Surg Pathol. 1998;22:709-721.
6. Billings SD, Roth LM, Ulbright TM.Microcystic Leydig cell tumors mimicking yolk sac tumor: A report of four cases. Am J Surg Pathol. 1999;23:546-551.
7. Ulbright TM, Young RH. Seminoma with tubular, microcystic, and related patterns: A study of 28 cases of unusual morphologic variants that often cause confusion with yolk sac tumor. Am J Surg Pathol. 2005;29:500-505.
8. Young RH, Finlayson N, Scully RE. Tubular seminoma. Report of a case. Arch Pathol Lab Med. 1989;113:414-416.
9. Zavala-Pompa A, Ro JY, el-Naggar AK, et al. Tubular seminoma. An immunohistochemical and DNA flow-cytometric study of four cases. Am J Clin Pathol. 1994;102:397-401.
10. Ulbright TM, Srigley JR, Reuter VE, et al. Sex cord-stromal tumors of the testis with entrapped germ cells: A lesion mimicking unclassified mixed germ cell sex cord-stromal tumors. Am J Surg Pathol. 2000;24:535-542.
11. Vallangeon BD, Eble JN, Ulbright TM. Macroscopic Sertoli cell nodule: A study of 6 cases that presented as testicular masses. Am J Surg Pathol. 2010;34:1874-1880.
12. Emerson RE, Ulbright TM. The use of immunohistochemistry in the differential diagnosis of tumors of the testis and paratestis. Semin Diagn Pathol. 2005;22:33-50.
13. Iczkowski KA, Bostwick DG, Roche PC, et al. Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. Mod Pathol. 1998;11:774-779.
14. Ulbright TM. The most common, clinically significant misdiagnoses in testicular tumor pathology, and how to avoid them. Adv Anat Pathol. 2008;15:18-27.
15. Young RH. Testicular tumors-some new and a few perennial problems. Arch Pathol Lab Med. 2008;132:548-564.
16. Sangoi AR, McKenney JK. A tissue microarray-based comparative analysis of novel and traditional immunohistochemical markers in the distinction between adrenal cortical lesions and pheochromocytoma. Am J Surg Pathol. 2010;34:423-432.
17. Zhao C, Barner R, Vinh TN, et al. SF-1 is a diagnostically useful immunohistochemical marker and comparable to other sex cordstromal tumor markers for the differential diagnosis of ovarian Sertoli cell tumor. Int J Gynecol Pathol. 2008;27:507-514.
18. Zhao C, Vinh TN, McManus K, et al. Identification of the most sensitive and robust immunohistochemical markers in different categories of ovarian sex cord-stromal tumors. Am J Surg Pathol. 2009;33:354-366.
19. Herrera LP, Amin M, Schwartz JD, et al. Detailed immunohistochemical characterization in the spectrum of sex cord stromal tumors of the testis using novel and established immunohistochemical markers: A study of 41 cases. Mod Pathol. 2011;24(suppl 1):197A.
20. Aron M, Gown AM, Balzer BL, et al. Comparative utility of novel nuclear markers steroidogenic factor and forkhead box L2 in the diagnosis of sex cord stromal tumors of the testis. Mod Pathol. 2012;25(suppl 2):190A.