The most common, clinically significant misdiagnoses in testicular tumor pathology, and how to avoid them

Advances in Anatomic Pathology

Volumn 15, Issue 1, 2008, Pages 18-27

  Ulbright, Thomas M ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY HEALTH   (United States)

Author keywords

Seminoma; Sertoli cell tumor; Testicular neoplasms; Yolk sac tumor

Indexed keywords

CANCER RADIOTHERAPY; CHORIOCARCINOMA; DIAGNOSTIC ERROR; EMBRYONAL CARCINOMA; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; ORCHITIS; PRIORITY JOURNAL; REVIEW; SEMINOMA; SERTOLI CELL; SYNCYTIOTROPHOBLAST; TESTIS TUMOR; TUMOR DIAGNOSIS; TUMOR DIFFERENTIATION; DIFFERENTIAL DIAGNOSIS; MALE; PATHOLOGY; SERTOLI CELL TUMOR; YOLK SAC TUMOR;

CARCINOMA, EMBRYONAL; DIAGNOSIS, DIFFERENTIAL; DIAGNOSTIC ERRORS; ENDODERMAL SINUS TUMOR; HUMANS; MALE; SEMINOMA; SERTOLI CELL TUMOR; TESTICULAR NEOPLASMS;

EID: 39149091444     PISSN: 10724109     EISSN: 15334031     Source Type: Journal    
DOI: 10.1097/PAP.0b013e318159475d     Document Type: Review

References (50)

1. Ulbright TM. Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues. Mod Pathol. 2005;18(suppl 2):S61-S79.
2. Tickoo SK, Hutchinson B, Bacik J, et al. Testicular seminoma: a clinicopathologic and immunohistochemical study of 105 cases with special reference to seminomas with atypical features. Int J Surg Pathol. 2002;10:23-32.
3. Srigley JR, Mackay B, Toth P, et al. The ultrastructure and histogenesis of male germ neoplasia with emphasis on seminoma with early carcinomatous features. Ultrastruc Pathol. 1988;12:67-86.
4. Oosterhuis JW, Castedo SM, de Jong B, et al. Ploidy of primary germ cell tumors of the testis. Pathogenetic and clinical relevance. Lab Invest. 1989;60:14-21.
5. Ferreiro JA. Ber-H2 expression in testicular germ cell tumors. Hum Pathol. 1994;25:522-524.
6. Niehans GA, Manivel JC, Copland GT, et al. Immunohistochemistry of germ cell and trophoblastic neoplasms. Cancer. 1988;62:1113-1123.
7. Izquierdo MA, Van der Valk P, Van Ark-Otte J, et al. Differential expression of the c-kit proto-oncogene in germ cell tumours. J Pathol. 2004;177:253-258.
8. Ulbright TM, Roth LM, Brodhecker CA. Yolk sac differentiation in germ cell tumors: a morphologic study of 50 cases with emphasis on hepatic, enteric and parietal yolk sac features. Am J Surg Pathol. 1986;10:151-164.
9. Nazeer T, Ro JY, Amato RJ, et al. Histologically pure seminoma with elevated alpha-fetoprotein: a clinicopathologic study of ten cases. Oncol Rep. 1998;5:1425-1429.
10. Talerman A. Endodermal sinus (yolk sac) tumor elements in testicular germ-cell tumors in adults: comparison of prospective and retrospective studies. Cancer. 1980;46:1213-1217.
11. Ulbright TM, Young RH. Seminoma with tubular, microcystic, and related patterns: a study of 28 cases of unusual morphologic variants that often cause confusion with yolk sac tumor. Am J Surg Pathol. 2005;29:500-505.
12. Looijenga LH, Stoop H, de Leeuw HP, et al. POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors. Cancer Res. 2003;63:2244-2250.
13. Jones TD, Ulbright TM, Eble JN, et al. OCT4 staining in testicular tumors: a sensitive and specific marker for seminoma and embryonal carcinoma. Am J Surg Pathol. 2004;28:935-940.
14. Zynger DL, Dimov ND, Luan C, et al. Glypican 3: a novel marker in testicular germ cell tumors. Am J Surg Pathol. 2006;30:1570-1575.
15. Ota S, Hishinuma M, Yamauchi N, et al. Oncofetal protein glypican-3 in testicular germ-cell tumor. Virchows Arch. 2006;449:308-314.
16. Henley JD, Young RH, Ulbright TM. Malignant Sertoli cell tumors of the testis: a study of 13 examples of a neoplasm frequently misinterpreted as seminoma. Am J Surg Pathol. 2002;26:541-550.
17. Young RH, Finlayson N, Scully RE. Tubular seminoma. Report of a case. Arch Pathol Lab Med. 1989;113:414-416.
18. Zavala-Pompa A, Ro JY, El-Naggar AK, et al. Tubular seminoma: an immunohistochemical and DNA flow cytometric study of four cases. Am J Clin Pathol. 1994;102:397-401.
19. Bauman GS, Venkatesan VM, Ago CT, et al. Postoperative radiotherapy for Stage I/II seminoma: results for 212 patients. Int J Radiat Oncol Biol Phys. 1998;42:313-317.
20. Fossä SD, Horwich A, Russell JM, et al. Optimal planning target volume for stage I testicular seminoma: a Medical Research Council randomized trial. Medical Research Council Testicular Tumor Working Group. J Clin Oncol. 1999;17:1146-1154.
21. Miki T, Nonomura N, Saiki S, et al. Long-term results of adjuvant irradiation or surveillance in stage I testicular seminoma. Int J Urol. 1998;5:357-360.
22. Schmidberger H, Bamberg M, Meisner C, et al. Radiotherapy in stage IIA and IIB testicular seminoma with reduced portals: a prospective multicenter study. Int J Radiat Oncol Biol Phys. 1997;39:321-326.
23. Stein ME, Drumea K, Moshkowitz B, et al. Failure analysis in irradiated stage I testicular seminoma. Results of long-term followup (1968-1993). Urol Int. 1997;59:200-202.
24. Warszawski N, Schmucking M. Relapses in early-stage testicular seminoma: radiation therapy versus retroperitoneal lymphadenectomy. Scand J Urol Nephrol. 1997;31:355-359.
25. Iczkowski KA, Bostwick DG, Roche PC, et al. Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. Mod Pathol. 1998;11:774-779.
26. Kommoss F, Oliva E, Bittinger F, et al. Inhibin-alpha CD99, HEA125, PLAP, and chromogranin immunoreactivity in testicular neoplasms and the androgen insensitivity syndrome. Hum Pathol. 2000;31:1055-1061.
27. Aitchison M, Mufti GR, Farrell J, et al. Granulomatous orchitis: review of 15 cases. Br J Urol. 1990;66:312-314.
28. Henley JD, Young RH, Wade CL, et al. Seminomas with exclusive intertubular growth: a report of 12 clinically and grossly inconspicuous tumors. Am J Surg Pathol. 2004;28:1163-1168.
29. Browne TJ, Richie JP, Gilligan TD, et al. Intertubular growth in pure seminomas: associations with poor prognostic parameters. Hum Pathol. 2005;36:640-645.
30. Warde P, Specht L, Horwich A, et al. Prognostic factors for relapse in stage I seminoma managed by surveillance: a pooled analysis. J Clin Oncol. 2002;20:4448-4452.
31. Ferry JA, Harris NL, Young RH, et al. Malignant lymphoma of the testis, epididymis, and spermatic cord. A clinicopathologic study of 69 cases with immunophenotypic analysis. Am J Surg Pathol. 1994; 18:376-390.
32. Ferry JA, Ulbright TM, Young RH. Anaplastic large cell lymphoma presenting in the testis. J Urol Pathol. 1997;5:139-147.
33. Wick MR, Swanson PE, Manivel JC. Placental-like alkaline phosphatase reactivity in human tumors: an immunohistochemical study of 520 cases. Hum Pathol. 1987;18:946-954.
34. Ulbright TM, Srigley JR. Dermoid cyst of the testis: a study of five postpubertal cases, including a pilomatrixoma-like variant, with evidence supporting its separate classification from mature testicular teratoma. Am J Surg Pathol. 2001;25:788-793.
35. Leibovitch I, Foster RS, Ulbright TM, et al. Adult primary pure teratoma of the testis. The Indiana experience. Cancer. 1995;75: 2244-2250.
36. Sesterhenn IA, Mesonero C, Davis CJ, et al. Testicular teratomas in adults. Histopathology. 2002;41(suppl 1):24.
37. Simmonds PD, Lee AH, Theaker JM, et al. Primary pure teratoma of the testis. J Urol. 1996;155:939-942.
38. Manivel JC, Reinberg Y, Niehans GA, et al. Intratubular germ cell neoplasia in testicular teratomas and epidermoid cysts. Correlation with prognosis and possible biologic significance. Cancer. 1989;64:715-720.
39. Ulbright TM. Gonadal teratomas: a review and speculation. Adv Anat Pathol. 2004;11:10-23.
40. Balzer BL, Ulbright TM. Spontaneous regression of testicular germ cell tumors: an analysis of 42 cases. Am J Surg Pathol. 2006;30:858-865.
41. Talerman A. Spermatocytic seminoma: clinicopathological study of 22 cases. Cancer. 1980;45:2169-2176.
42. Rosai J, Silber I, Khodadoust K. Spermatocytic seminoma. I. Clinicopathologic study of six cases and review of the literature. Cancer. 1969;24:92-102.
43. Scully RE. Spermatocytic seminoma of the testis: a report of 3 cases and review of the literature. Cancer. 1961;14:788-794.
44. Burke AP, Mostofi FK. Spermatocytic seminoma: a clinicopathologic study of 79 cases. J Urol Pathol. 1993;1:21-32.
45. Albores-Saavedra J, Huffman H, Alvarado-Cabrero I, et al. Anaplastic variant of spermatocytic seminoma. Hum Pathol. 1996;27:650-655.
46. Skakkebaek NE, Berthelsen JG, Giwercman A, et al. Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. Int J Androl. 1987;10:19-28.
47. Dekker I, Rozeboom T, Delemarre J, et al. Placental-like alkaline phosphatase and DNA flow cytometry in spermatocytic seminoma. Cancer. 1992;69:993-996.
48. Cummings OW, Ulbright TM, Eble JN, et al. Spermatocytic seminoma: an immunohistochemical study. Hum Pathol. 1994;25:54-59.
49. Kraggerud SM, Berner A, Bryne M, et al. Spermatocytic seminoma as compared to classical seminoma: an immunohistochemical and DNA flow cytometric study. APMIS. 1999;107:297-302.
50. Stoop H, van Gurp R, de Krijger R, et al. Reactivity of germ cell maturation stage-specific markers in spermatocytic seminoma: diagnostic and etiological implications. Lab Invest. 2001;81:919-928.