SF-1 is a diagnostically useful immunohistochemical marker and comparable to other sex cord-stromal tumor markers for the differential diagnosis of ovarian sertoli cell tumor

International Journal of Gynecological Pathology

Volumn 27, Issue 4, 2008, Pages 507-514

  Zhao, Chengquan ^a,b   Barner, Ross ^b,d   Vinh, Tuyethoa N ^b   McManus, Kim ^a   Dabbs, David ^a   Vang, Russell ^c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^c JOHNS HOPKINS HOSPITAL   (United States)

^d WALTER REED ARMY MEDICAL CENTER   (United States)

Author keywords

Ad4 binding protein; Ovary; Sertoli cell tumor; SF 1; Steroidogenic factor 1

Indexed keywords

INHIBIN; STEROIDOGENIC FACTOR 1; WT1 PROTEIN; NUCLEAR PROTEIN; TUMOR MARKER; UNCLASSIFIED DRUG; WTAP PROTEIN, HUMAN;

ARTICLE; CALCULATION; CARCINOID; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; ENDOMETRIOID CARCINOMA; ENDOMETRIUM TUMOR; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; OVARIAN SERTOLI CELL TUMOR; OVARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SERTOLI CELL TUMOR; BIOSYNTHESIS; METABOLISM; RETROSPECTIVE STUDY;

CARCINOMA, ENDOMETRIOID; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INHIBINS; NUCLEAR PROTEINS; OVARIAN NEOPLASMS; RETROSPECTIVE STUDIES; SERTOLI CELL TUMOR; STEROIDOGENIC FACTOR 1; TUMOR MARKERS, BIOLOGICAL;

EID: 58149187140     PISSN: 02771691     EISSN: None     Source Type: Journal    
DOI: 10.1097/PGP.0b013e31817c1b0a     Document Type: Article

References (37)

1. Oliva E, Alvarez T, Young RH. Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases. Am J Surg Pathol 2005;29:143-56.
2. Zhao C, Bratthauer GL, Barner R, et al. Comparative analysis of alternative and traditional immunohistochemical markers for the distinction of ovarian Sertoli cell tumor from endometrioid tumors and carcinoid tumor: a study of 160 cases. Am J Surg Pathol 2007;31:255-66.
3. Zhao C, Bratthauer GL, Barner R, et al. Diagnostic utility of WT1 immunostaining in ovarian Sertoli cell tumor. Am J Surg Pathol 2007;31:1378-86.
4. Cathro HP, Stoler MH. The utility of calretinin, inhibin, and WT1 immunohistochemical staining in the differential diagnosis of ovarian tumors. Hum Pathol 2005;36:195-201.
5. Choi YL, Kim HS, Ahn G. Immunoexpression of inhibin alpha subunit, inhibin/activin betaA subunit and CD99 in ovarian tumors. Arch Pathol Lab Med 2000;124:563-9.
6. Ciris M, Erhan Y, Zekioglu O, et al. Inhibin alpha and beta expression in ovarian stromal tumors and their histological equivalences. Acta Obstet Gynecol Scand 2004;83:491-6.
7. Dionigi A, Facco C, Tibiletti MG, et al. Ovarian metastases from colorectal carcinoma. Clinicopathologic profile, immunophenotype, and karyotype analysis. Am J Clin Pathol 2000;114:111-22.
8. Doglioni C, Tos AP, Laurino L, et al. Calretinin: a novel immunocytochemical marker for mesothelioma. Am J Surg Pathol 1996;20:1037-46.
9. Flemming P, Grothe W, Maschek H, et al. The site of inhibin production in ovarian neoplasms. Histopathology 1996;29:465-8.
10. Guerrieri C, Franlund B, Malmstrom H, et al. Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7. Int J Gynecol Pathol 1998;17:266-71.
11. Hildebrandt RH, Rouse RV, Longacre TA. Value of inhibin in the identification of granulosa cell tumors of the ovary. Hum Pathol 1997;28:1387-95.
12. Kommoss F, Oliva E, Bhan AK, et al. Inhibin expression in ovarian tumors and tumor-like lesions: an immunohistochemical study. Mod Pathol 1998;11:656-64.
13. Lugli A, Forster Y, Haas P, et al. Calretinin expression in human normal and neoplastic tissues: a tissue microarray analysis on 5233 tissue samples. Hum Pathol 2003;34:994-1000.
14. Matias-Guiu X, Pons C, Prat J. Mullerian inhibiting substance, alpha-inhibin, and CD99 expression in sex cord-stromal tumors and endometrioid ovarian carcinomas resembling sex cord-stromal tumors. Hum Pathol 1998;29:840-5.
15. McCluggage WG, Maxwell P. Adenocarcinomas of various sites may exhibit immunoreactivity with anti-inhibin antibodies. Histopathology 1999;35:216-20.
16. McCluggage WG, Maxwell P. Immunohistochemical staining for calretinin is useful in the diagnosis of ovarian sex cordstromal tumours. Histopathology 2001;38:403-8.
17. Movahedi-Lankarani S, Kurman RJ. Calretinin, a more sensitive but less specific marker than alpha-inhibin for ovarian sex cord-stromal neoplasms: An immunohistochemical study of 215 cases. Am J Surg Pathol 2002;26:1477-83.
18. Ordi J, Schammel DP, Rasekh L, et al. Sertoliform endometrioid carcinomas of the ovary: a clinicopathologic and immunohistochemical study of 13 cases. Mod Pathol 1999;12:933-40.
19. Pelkey TJ, Frierson HF Jr, Mills SE, et al. The diagnostic utility of inhibin staining in ovarian neoplasms. Int J Gynecol Pathol 1998;17:97-105.
20. Stewart CJ, Jeffers MD, Kennedy A. Diagnostic value of inhibin immunoreactivity in ovarian gonadal stromal tumours and their histological mimics. Histopathology 1997;31:67-74.
21. Zheng W, Luo MP, Welt C, et al. Imbalanced expression of inhibin and activin subunits in primary epithelial ovarian cancer. Gynecol Oncol 1998;69:23-31.
22. Anttonen M, Unkila-Kallio L, Leminen A, et al. High GATA-4 expression associates with aggressive behavior, whereas low anti-Müllerian hormone expression associates with growth potential of ovarian granulosa cell tumors. J Clin Endocrinol Metab 2005;90:6529-35.
23. Asa SL, Bamberger AM, Cao B, et al. The transcription activator steroidogenic factor-1 is preferentially expressed in the human pituitary gonadotroph. J Clin Endocrinol Metab 1996;81:2165-70.
24. Bamberger AM, Ezzat S, Cao B, et al. Expression of steroidogenic factor-1 (SF-1) mRNA and protein in the human placenta. Mol Hum Reprod 1996;2:457-61.
25. de Santa Barbara P, Moniot B, Poulat F, et al. Expression and subcellular localization of SF-1, SOX9, WT1, and AMH proteins during early human testicular development. Dev Dyn 2000;217:293-98.
26. Hanley NA, Ikeda Y, Luo X, et al. Steroidogenic factor 1 (SF-1) is essential for ovarian development and function. Mol Cell Endocrinol 2000;163:27-32.
27. Merhi RA, Guillaud L, Delouis C, et al. Establishment and characterization of immortalized ovine Sertoli cell lines. In Vitro Cell Dev Biol Anim 2001;37:581-8.
28. Ozisik G, Achermann JC, Jameson JL. The role of SF1 in adrenal and reproductive function: insight from naturally occurring mutations in humans. Mol Genet Metab 2002;76:85-91.
29. Ozisik G, Achermann JC, Meeks JJ, et al. SF1 in the development of the adrenal gland and gonads. Horm Res 2003;59:94-8.
30. Sato Y, Suzuki T, Hidaka K, et al. Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: Correlation with adrenal 4 binding protein/steroidogenic factor-1 immunolocalization during the menstrual cycle. J Clin Endocrinol Metab 2003;88:3415-20.
31. Zhao C, Bratthauer GL, Barner R, et al. Immunohistochemical analysis of Sox9 in ovarian Sertoli cell tumors and other tumors in the differential diagnosis. Int J Gynecol Pathol 2007;26:1-9.
32. Kiiveri S, Liu J, Arola J, et al. Transcription factors GATA-6, SF-1, and cell proliferation in human adrenocortical tumors. Mol Cell Endocrinol 2005;233:47-56.
33. Takayama K, Sasano H, Fukaya T, et al. Immunohistochemical localization of Ad4-binding protein with correlation to steroidogenic enzyme expression in cycling human ovaries and sex cord stromal tumors. J Clin Endocrinol Metab 1995;80:2815-21.
34. Zhao C, Vinh TN, McManus K, et al. Comparative immunohistochemical analysis of various sex cord-stromal markers in different categories of ovarian sex cord-stromal tumors. Mod Pathol 2008;21(suppl 1):229A (Abstract no. 1051).
35. Sasano H, Kaga K, Sato S, et al. Adrenal 4-binding protein in common epithelial and metastatic tumors of the ovary. Hum Pathol 1996;27:595-8.
36. Abd-Elaziz M, Moriya T, Akahira J, et al. Immunolocalization of nuclear transcription factors, DAX-1 and Ad4BP/SF-1, in human common epithelial ovarian tumors: correlations with StAR and steroidogenic enzymes in epithelial ovarian carcinoma. Int J Gynecol Pathol 2005;24:153-63.
37. Young RH, Scully RE. Ovarian tumors of probable wolffian origin. A report of 11 cases. Am J Surg Pathol 1983;7:125-35.