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Volumn 26, Issue 8, 2011, Pages 1007-1013

Association between genetic polymorphisms of CYP2d6 and outcomes in breast cancer patients with tamoxifen treatment

Author keywords

Breast neoplasms; Cytochrome p 450 CYP2D6; Polymorphism; Single nucleotide; Survival analysis; Tamoxifen

Indexed keywords

ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; CYTOCHROME P450 2D6; TAMOXIFEN;

EID: 80052665548     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2011.26.8.1007     Document Type: Article
Times cited : (29)

References (30)
  • 1
    • 19344364880 scopus 로고    scopus 로고
    • Early Breast Cancer Trialists' Collaborative Group, (EBCTCG)., Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomized trials
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomized trials. Lancet 2005; 365: 1687-717.
    • (2005) Lancet , vol.365 , pp. 1687-1717
    • Sathish, R.1
  • 2
    • 4243063941 scopus 로고    scopus 로고
    • Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6
    • Desta Z, Ward BA, Soukhova NV, Flockhart DA. Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther 2004; 310: 1062-75.
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 1062-1075
    • Desta, Z.1    Ward, B.A.2    Soukhova, N.V.3    Flockhart, D.A.4
  • 3
    • 33745939124 scopus 로고    scopus 로고
    • Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells
    • Lim YC, Li L, Desta Z, Zhao Q, Rae JM, Flockhart DA, Skaar TC. Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells. J Pharmacol Exp Ther 2006; 318: 503-12.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 503-512
    • Lim, Y.C.1    Li, L.2    Desta, Z.3    Zhao, Q.4    Rae, J.M.5    Flockhart, D.A.6    Skaar, T.C.7
  • 4
    • 0019411776 scopus 로고
    • Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues
    • Borgna JL, Rochefort H. Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues. J Biol Chem 1981; 256: 859-68.
    • (1981) J Biol Chem , vol.256 , pp. 859-868
    • Borgna, J.L.1    Rochefort, H.2
  • 6
    • 17644387537 scopus 로고    scopus 로고
    • Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen
    • Lim YC, Desta Z, Flockhart DA, Skaar TC. Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen. Cancer Chemother Pharmacol 2005; 55: 471-8.
    • (2005) Cancer Chemother Pharmacol , vol.55 , pp. 471-478
    • Lim, Y.C.1    Desta, Z.2    Flockhart, D.A.3    Skaar, T.C.4
  • 7
    • 34548532227 scopus 로고    scopus 로고
    • Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer
    • Lim HS, Lee HJ, Lee KS, Lee ES, Jang IJ, Ro J. Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer. J Clin Oncol 2007; 25: 3837-45.
    • (2007) J Clin Oncol , vol.25 , pp. 3837-3845
    • Lim, H.S.1    Lee, H.J.2    Lee, K.S.3    Lee, E.S.4    Jang, I.J.5    Ro, J.6
  • 11
    • 67649401803 scopus 로고    scopus 로고
    • Discovery of novel functional variants and extensive evaluation of CYP2D6 genetic polymorphisms in Koreans
    • Lee SJ, Lee SS, Jung HJ, Kim HS, Park SJ, Yeo CW, Shin JG. Discovery of novel functional variants and extensive evaluation of CYP2D6 genetic polymorphisms in Koreans. Drug Metab Dispos 2009; 37: 1464-70.
    • (2009) Drug Metab Dispos , vol.37 , pp. 1464-1470
    • Lee, S.J.1    Lee, S.S.2    Jung, H.J.3    Kim, H.S.4    Park, S.J.5    Yeo, C.W.6    Shin, J.G.7
  • 12
    • 33746700165 scopus 로고    scopus 로고
    • The association of CYP2D6 *10 polymorphism with breast cancer risk and clinico-pathologic characteristics in Chinese women
    • Li H, Feng L, Xu Y, Yao L, Ouyang T, Li J, Wang T, Fan Z, Lin B, Xie Y. The association of CYP2D6 *10 polymorphism with breast cancer risk and clinico-pathologic characteristics in Chinese women. Acta Oncol 2006; 45: 597-601.
    • (2006) Acta Oncol , vol.45 , pp. 597-601
    • Li, H.1    Feng, L.2    Xu, Y.3    Yao, L.4    Ouyang, T.5    Li, J.6    Wang, T.7    Fan, Z.8    Lin, B.9    Xie, Y.10
  • 14
    • 61449171134 scopus 로고    scopus 로고
    • Genetic polymorphisms of CYP2D6 10 and CYP2C19 2, 3 are not associated with prognosis, endometrial thickness, or bone mineral density in Japanese breast cancer patients treated with adjuvant tamoxifen
    • Okishiro M, Taguchi T, Kim SJ, Shimazu K, Tamaki Y, Noguchi S. Genetic polymorphisms of CYP2D6 10 and CYP2C19 2, 3 are not associated with prognosis, endometrial thickness, or bone mineral density in Japanese breast cancer patients treated with adjuvant tamoxifen. Cancer 2009; 115: 952-61.
    • (2009) Cancer , vol.115 , pp. 952-961
    • Okishiro, M.1    Taguchi, T.2    Kim, S.J.3    Shimazu, K.4    Tamaki, Y.5    Noguchi, S.6
  • 15
    • 0033461165 scopus 로고    scopus 로고
    • Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data
    • Gaedigk A, Gotschall RR, Forbes NS, Simon SD, Kearns GL, Leeder JS. Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data. Pharmacogenetics 1999; 9: 669-82.
    • (1999) Pharmacogenetics , vol.9 , pp. 669-682
    • Gaedigk, A.1    Gotschall, R.R.2    Forbes, N.S.3    Simon, S.D.4    Kearns, G.L.5    Leeder, J.S.6
  • 21
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences
    • Sachse C, Brockmöller J, Bauer S, Roots I. Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet 1997; 60: 284-95.
    • (1997) Am J Hum Genet , vol.60 , pp. 284-295
    • Sachse, C.1    Brockmöller, J.2    Bauer, S.3    Roots, I.4
  • 22
    • 0036124107 scopus 로고    scopus 로고
    • CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants
    • Bradford LD. CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants. Pharmacogenomics 2002; 3: 229-43.
    • (2002) Pharmacogenomics , vol.3 , pp. 229-243
    • Bradford, L.D.1
  • 24
    • 34248208754 scopus 로고    scopus 로고
    • Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer
    • Wegman P, Elingarami S, Carstensen J, Stål O, Nordenskjöld B, Wingren S. Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer. Breast Cancer Res 2007; 9: R7.
    • (2007) Breast Cancer Res , vol.9
    • Wegman, P.1    Elingarami, S.2    Carstensen, J.3    Stål, O.4    Nordenskjöld, B.5    Wingren, S.6
  • 25
    • 84856227640 scopus 로고    scopus 로고
    • Lack of any association between functionally significant CYP2D6 polymorphisms and clinical outcomes in early breast cancer patients receiving adjuvant tamoxifen treatment
    • Doi: 10.1007/s10549-011-1425-2
    • Park IH, Ro J, Park S, Lim HS, Lee KS, Kang HS, Jung SY, Lee S. Lack of any association between functionally significant CYP2D6 polymorphisms and clinical outcomes in early breast cancer patients receiving adjuvant tamoxifen treatment. Breast Cancer Res Treat 2011. Doi: 10.1007/s10549-011-1425-2.
    • (2011) Breast Cancer Res Treat
    • Park, I.H.1    Ro, J.2    Park, S.3    Lim, H.S.4    Lee, K.S.5    Kang, H.S.6    Jung, S.Y.7    Lee, S.8
  • 26
    • 79959353859 scopus 로고    scopus 로고
    • Lack of correlation between gene variants in tamoxifen metabolizing enzymes with primary endpoints in the ATAC Trial. Program and abstracts of the 33rd Annual San Antonio Breast Cancer Symposium
    • Rae JM, Drury S, Hayes DF, Stearns V, Thibert JN, Haynes BP, Salter J, Pineda S, Cuzick J, Dowsett M. Lack of correlation between gene variants in tamoxifen metabolizing enzymes with primary endpoints in the ATAC Trial. Program and abstracts of the 33rd Annual San Antonio Breast Cancer Symposium. Cancer Res 2010; 70: S1-7.
    • (2010) Cancer Res , vol.70
    • Rae, J.M.1    Drury, S.2    Hayes, D.F.3    Stearns, V.4    Thibert, J.N.5    Haynes, B.P.6    Salter, J.7    Pineda, S.8    Cuzick, J.9    Dowsett, M.10
  • 27
    • 79959367176 scopus 로고    scopus 로고
    • Outcome according to CYP2D6 Genotype among postmenopausal women with endocrine-responsive early invasive breast cancer randomized in the BIG 1-98 Trial. Program and abstracts of the 33rd Annual San Antonio Breast Cancer Symposium
    • Leyland-Jones B, Regan MM, Bouzyk M, Kammler R, Tang W, Pagani O, Malbach R, Dell'Orto P, Thürlimann B, Price KN, Viale G. Outcome according to CYP2D6 Genotype among postmenopausal women with endocrine-responsive early invasive breast cancer randomized in the BIG 1-98 Trial. Program and abstracts of the 33rd Annual San Antonio Breast Cancer Symposium. Cancer Res 2010; 70: S1-8.
    • (2010) Cancer Res , vol.70
    • Leyland-Jones, B.1    Regan, M.M.2    Bouzyk, M.3    Kammler, R.4    Tang, W.5    Pagani, O.6    Malbach, R.7    Dell'Orto, P.8    Thürlimann, B.9    Price, K.N.10    Viale, G.11
  • 28
    • 77955556907 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 and outcomes of adjuvant tamoxifen therapy: results of a meta-analysis
    • Seruga B, Amir E. Cytochrome P450 2D6 and outcomes of adjuvant tamoxifen therapy: results of a meta-analysis. Breast Cancer Res Treat 2010; 122: 609-17.
    • (2010) Breast Cancer Res Treat , vol.122 , pp. 609-617
    • Seruga, B.1    Amir, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.