-
1
-
-
19344364880
-
Early Breast Cancer Trialists' Collaborative Group, (EBCTCG)., Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomized trials
-
Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomized trials. Lancet 2005; 365: 1687-717.
-
(2005)
Lancet
, vol.365
, pp. 1687-1717
-
-
Sathish, R.1
-
2
-
-
4243063941
-
Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6
-
Desta Z, Ward BA, Soukhova NV, Flockhart DA. Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther 2004; 310: 1062-75.
-
(2004)
J Pharmacol Exp Ther
, vol.310
, pp. 1062-1075
-
-
Desta, Z.1
Ward, B.A.2
Soukhova, N.V.3
Flockhart, D.A.4
-
3
-
-
33745939124
-
Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells
-
Lim YC, Li L, Desta Z, Zhao Q, Rae JM, Flockhart DA, Skaar TC. Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells. J Pharmacol Exp Ther 2006; 318: 503-12.
-
(2006)
J Pharmacol Exp Ther
, vol.318
, pp. 503-512
-
-
Lim, Y.C.1
Li, L.2
Desta, Z.3
Zhao, Q.4
Rae, J.M.5
Flockhart, D.A.6
Skaar, T.C.7
-
4
-
-
0019411776
-
Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues
-
Borgna JL, Rochefort H. Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues. J Biol Chem 1981; 256: 859-68.
-
(1981)
J Biol Chem
, vol.256
, pp. 859-868
-
-
Borgna, J.L.1
Rochefort, H.2
-
5
-
-
3342932419
-
Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen
-
Johnson MD, Zuo H, Lee KH, Trebley JP, Rae JM, Weatherman RV, Desta Z, Flockhart DA, Skaar TC. Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen. Breast Cancer Res Treat 2004; 85: 151-9.
-
(2004)
Breast Cancer Res Treat
, vol.85
, pp. 151-159
-
-
Johnson, M.D.1
Zuo, H.2
Lee, K.H.3
Trebley, J.P.4
Rae, J.M.5
Weatherman, R.V.6
Desta, Z.7
Flockhart, D.A.8
Skaar, T.C.9
-
6
-
-
17644387537
-
Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen
-
Lim YC, Desta Z, Flockhart DA, Skaar TC. Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen. Cancer Chemother Pharmacol 2005; 55: 471-8.
-
(2005)
Cancer Chemother Pharmacol
, vol.55
, pp. 471-478
-
-
Lim, Y.C.1
Desta, Z.2
Flockhart, D.A.3
Skaar, T.C.4
-
7
-
-
34548532227
-
Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer
-
Lim HS, Lee HJ, Lee KS, Lee ES, Jang IJ, Ro J. Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer. J Clin Oncol 2007; 25: 3837-45.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3837-3845
-
-
Lim, H.S.1
Lee, H.J.2
Lee, K.S.3
Lee, E.S.4
Jang, I.J.5
Ro, J.6
-
8
-
-
38349132802
-
The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype
-
Gaedigk A, Simon SD, Pearce RE, Bradford LD, Kennedy MJ, Leeder JS. The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype. Clin Pharmacol Ther 2008; 83: 234-42.
-
(2008)
Clin Pharmacol Ther
, vol.83
, pp. 234-242
-
-
Gaedigk, A.1
Simon, S.D.2
Pearce, R.E.3
Bradford, L.D.4
Kennedy, M.J.5
Leeder, J.S.6
-
9
-
-
33644639136
-
Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes
-
Goetz MP, Rae JM, Suman VJ, Safgren SL, Ames MM, Visscher DW, Reynolds C, Couch FJ, Lingle WL, Flockhart DA, Desta Z, Perez EA, Ingle JN. Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. J Clin Oncol 2005; 23: 9312-8.
-
(2005)
J Clin Oncol
, vol.23
, pp. 9312-9318
-
-
Goetz, M.P.1
Rae, J.M.2
Suman, V.J.3
Safgren, S.L.4
Ames, M.M.5
Visscher, D.W.6
Reynolds, C.7
Couch, F.J.8
Lingle, W.L.9
Flockhart, D.A.10
Desta, Z.11
Perez, E.A.12
Ingle, J.N.13
-
10
-
-
36349024762
-
Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes
-
Schroth W, Antoniadou L, Fritz P, Schwab M, Muerdter T, Zanger UM, Simon W, Eichelbaum M, Brauch H. Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes. J Clin Oncol 2007; 25: 5187-93.
-
(2007)
J Clin Oncol
, vol.25
, pp. 5187-5193
-
-
Schroth, W.1
Antoniadou, L.2
Fritz, P.3
Schwab, M.4
Muerdter, T.5
Zanger, U.M.6
Simon, W.7
Eichelbaum, M.8
Brauch, H.9
-
11
-
-
67649401803
-
Discovery of novel functional variants and extensive evaluation of CYP2D6 genetic polymorphisms in Koreans
-
Lee SJ, Lee SS, Jung HJ, Kim HS, Park SJ, Yeo CW, Shin JG. Discovery of novel functional variants and extensive evaluation of CYP2D6 genetic polymorphisms in Koreans. Drug Metab Dispos 2009; 37: 1464-70.
-
(2009)
Drug Metab Dispos
, vol.37
, pp. 1464-1470
-
-
Lee, S.J.1
Lee, S.S.2
Jung, H.J.3
Kim, H.S.4
Park, S.J.5
Yeo, C.W.6
Shin, J.G.7
-
12
-
-
33746700165
-
The association of CYP2D6 *10 polymorphism with breast cancer risk and clinico-pathologic characteristics in Chinese women
-
Li H, Feng L, Xu Y, Yao L, Ouyang T, Li J, Wang T, Fan Z, Lin B, Xie Y. The association of CYP2D6 *10 polymorphism with breast cancer risk and clinico-pathologic characteristics in Chinese women. Acta Oncol 2006; 45: 597-601.
-
(2006)
Acta Oncol
, vol.45
, pp. 597-601
-
-
Li, H.1
Feng, L.2
Xu, Y.3
Yao, L.4
Ouyang, T.5
Li, J.6
Wang, T.7
Fan, Z.8
Lin, B.9
Xie, Y.10
-
13
-
-
47749105202
-
Association between CYP2D6 *10 genotype and survival of breast cancer patients receiving tamoxifen treatment
-
Xu Y, Sun Y, Yao L, Shi L, Wu Y, Ouyang T, Li J, Wang T, Fan Z, Fan T, Lin B, He L, Li P, Xie Y. Association between CYP2D6 *10 genotype and survival of breast cancer patients receiving tamoxifen treatment. Ann Oncol 2008; 19: 1423-9.
-
(2008)
Ann Oncol
, vol.19
, pp. 1423-1429
-
-
Xu, Y.1
Sun, Y.2
Yao, L.3
Shi, L.4
Wu, Y.5
Ouyang, T.6
Li, J.7
Wang, T.8
Fan, Z.9
Fan, T.10
Lin, B.11
He, L.12
Li, P.13
Xie, Y.14
-
14
-
-
61449171134
-
Genetic polymorphisms of CYP2D6 10 and CYP2C19 2, 3 are not associated with prognosis, endometrial thickness, or bone mineral density in Japanese breast cancer patients treated with adjuvant tamoxifen
-
Okishiro M, Taguchi T, Kim SJ, Shimazu K, Tamaki Y, Noguchi S. Genetic polymorphisms of CYP2D6 10 and CYP2C19 2, 3 are not associated with prognosis, endometrial thickness, or bone mineral density in Japanese breast cancer patients treated with adjuvant tamoxifen. Cancer 2009; 115: 952-61.
-
(2009)
Cancer
, vol.115
, pp. 952-961
-
-
Okishiro, M.1
Taguchi, T.2
Kim, S.J.3
Shimazu, K.4
Tamaki, Y.5
Noguchi, S.6
-
15
-
-
0033461165
-
Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data
-
Gaedigk A, Gotschall RR, Forbes NS, Simon SD, Kearns GL, Leeder JS. Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data. Pharmacogenetics 1999; 9: 669-82.
-
(1999)
Pharmacogenetics
, vol.9
, pp. 669-682
-
-
Gaedigk, A.1
Gotschall, R.R.2
Forbes, N.S.3
Simon, S.D.4
Kearns, G.L.5
Leeder, J.S.6
-
16
-
-
33947355059
-
Ontogeny of dextromethorphan O- and N-demethylation in the first year of life
-
Blake MJ, Gaedigk A, Pearce RE, Bomgaars LR, Christensen ML, Stowe C, James LP, Wilson JT, Kearns GL, Leeder JS. Ontogeny of dextromethorphan O- and N-demethylation in the first year of life. Clin Pharmacol Ther 2007; 81: 510-6.
-
(2007)
Clin Pharmacol Ther
, vol.81
, pp. 510-516
-
-
Blake, M.J.1
Gaedigk, A.2
Pearce, R.E.3
Bomgaars, L.R.4
Christensen, M.L.5
Stowe, C.6
James, L.P.7
Wilson, J.T.8
Kearns, G.L.9
Leeder, J.S.10
-
17
-
-
70349575970
-
Association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort
-
Henry NL, Rae JM, Li L, Azzouz F, Skaar TC, Desta Z, Sikora MJ, Philips S, Nguyen AT, Storniolo AM, Hayes DF, Flockhart DA, Stearns V. Association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort. Breast Cancer Res Treat 2009; 117: 571-5.
-
(2009)
Breast Cancer Res Treat
, vol.117
, pp. 571-575
-
-
Henry, N.L.1
Rae, J.M.2
Li, L.3
Azzouz, F.4
Skaar, T.C.5
Desta, Z.6
Sikora, M.J.7
Philips, S.8
Nguyen, A.T.9
Storniolo, A.M.10
Hayes, D.F.11
Flockhart, D.A.12
Stearns, V.13
-
18
-
-
72449150287
-
Impact of CYP2D6 polymorphisms in tamoxifen adjuvant breast cancer treatment
-
Ramón y Cajal T, Altés A, Paré L, del Rio E, Alonso C, Barnadas A, Baiget M. Impact of CYP2D6 polymorphisms in tamoxifen adjuvant breast cancer treatment. Breast Cancer Res Treat 2010; 119: 33-8.
-
(2010)
Breast Cancer Res Treat
, vol.119
, pp. 33-38
-
-
Ramón y Cajal, T.1
Altés, A.2
Paré, L.3
del Rio, E.4
Alonso, C.5
Barnadas, A.6
Baiget, M.7
-
19
-
-
0033887223
-
CYP2D6 gene polymorphism in caucasian smokers: lung cancer susceptibility and phenotype-genotype relationships
-
Laforest L, Wikman H, Benhamou S, Saarikoski ST, Bouchardy C, Hirvonen A, Dayer P, Husgafvel-Pursiainen K. CYP2D6 gene polymorphism in caucasian smokers: lung cancer susceptibility and phenotype-genotype relationships. Eur J Cancer 2000; 36: 1825-32.
-
(2000)
Eur J Cancer
, vol.36
, pp. 1825-1832
-
-
Laforest, L.1
Wikman, H.2
Benhamou, S.3
Saarikoski, S.T.4
Bouchardy, C.5
Hirvonen, A.6
Dayer, P.7
Husgafvel-Pursiainen, K.8
-
20
-
-
0028271144
-
CYP2D6 genotyping and the association with lung cancer susceptibility
-
Wolf CR, Smith CA, Bishop T, Forman D, Gough AC, Spurr NK. CYP2D6 genotyping and the association with lung cancer susceptibility. Pharmacogenetics 1994; 4: 104-6.
-
(1994)
Pharmacogenetics
, vol.4
, pp. 104-106
-
-
Wolf, C.R.1
Smith, C.A.2
Bishop, T.3
Forman, D.4
Gough, A.C.5
Spurr, N.K.6
-
21
-
-
0031038038
-
Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences
-
Sachse C, Brockmöller J, Bauer S, Roots I. Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet 1997; 60: 284-95.
-
(1997)
Am J Hum Genet
, vol.60
, pp. 284-295
-
-
Sachse, C.1
Brockmöller, J.2
Bauer, S.3
Roots, I.4
-
22
-
-
0036124107
-
CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants
-
Bradford LD. CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants. Pharmacogenomics 2002; 3: 229-43.
-
(2002)
Pharmacogenomics
, vol.3
, pp. 229-243
-
-
Bradford, L.D.1
-
23
-
-
77950502100
-
Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients
-
Kiyotani K, Mushiroda T, Imamura CK, Hosono N, Tsunoda T, Kubo M, Tanigawara Y, Flockhart DA, Desta Z, Skaar TC, Aki F, Hirata K, Takatsuka Y, Okazaki M, Ohsumi S, Yamakawa T, Sasa M, Nakamura Y, Zembutsu H. Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients. J Clin Oncol 2010; 28: 1287-93.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1287-1293
-
-
Kiyotani, K.1
Mushiroda, T.2
Imamura, C.K.3
Hosono, N.4
Tsunoda, T.5
Kubo, M.6
Tanigawara, Y.7
Flockhart, D.A.8
Desta, Z.9
Skaar, T.C.10
Aki, F.11
Hirata, K.12
Takatsuka, Y.13
Okazaki, M.14
Ohsumi, S.15
Yamakawa, T.16
Sasa, M.17
Nakamura, Y.18
Zembutsu, H.19
-
24
-
-
34248208754
-
Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer
-
Wegman P, Elingarami S, Carstensen J, Stål O, Nordenskjöld B, Wingren S. Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer. Breast Cancer Res 2007; 9: R7.
-
(2007)
Breast Cancer Res
, vol.9
-
-
Wegman, P.1
Elingarami, S.2
Carstensen, J.3
Stål, O.4
Nordenskjöld, B.5
Wingren, S.6
-
25
-
-
84856227640
-
Lack of any association between functionally significant CYP2D6 polymorphisms and clinical outcomes in early breast cancer patients receiving adjuvant tamoxifen treatment
-
Doi: 10.1007/s10549-011-1425-2
-
Park IH, Ro J, Park S, Lim HS, Lee KS, Kang HS, Jung SY, Lee S. Lack of any association between functionally significant CYP2D6 polymorphisms and clinical outcomes in early breast cancer patients receiving adjuvant tamoxifen treatment. Breast Cancer Res Treat 2011. Doi: 10.1007/s10549-011-1425-2.
-
(2011)
Breast Cancer Res Treat
-
-
Park, I.H.1
Ro, J.2
Park, S.3
Lim, H.S.4
Lee, K.S.5
Kang, H.S.6
Jung, S.Y.7
Lee, S.8
-
26
-
-
79959353859
-
Lack of correlation between gene variants in tamoxifen metabolizing enzymes with primary endpoints in the ATAC Trial. Program and abstracts of the 33rd Annual San Antonio Breast Cancer Symposium
-
Rae JM, Drury S, Hayes DF, Stearns V, Thibert JN, Haynes BP, Salter J, Pineda S, Cuzick J, Dowsett M. Lack of correlation between gene variants in tamoxifen metabolizing enzymes with primary endpoints in the ATAC Trial. Program and abstracts of the 33rd Annual San Antonio Breast Cancer Symposium. Cancer Res 2010; 70: S1-7.
-
(2010)
Cancer Res
, vol.70
-
-
Rae, J.M.1
Drury, S.2
Hayes, D.F.3
Stearns, V.4
Thibert, J.N.5
Haynes, B.P.6
Salter, J.7
Pineda, S.8
Cuzick, J.9
Dowsett, M.10
-
27
-
-
79959367176
-
Outcome according to CYP2D6 Genotype among postmenopausal women with endocrine-responsive early invasive breast cancer randomized in the BIG 1-98 Trial. Program and abstracts of the 33rd Annual San Antonio Breast Cancer Symposium
-
Leyland-Jones B, Regan MM, Bouzyk M, Kammler R, Tang W, Pagani O, Malbach R, Dell'Orto P, Thürlimann B, Price KN, Viale G. Outcome according to CYP2D6 Genotype among postmenopausal women with endocrine-responsive early invasive breast cancer randomized in the BIG 1-98 Trial. Program and abstracts of the 33rd Annual San Antonio Breast Cancer Symposium. Cancer Res 2010; 70: S1-8.
-
(2010)
Cancer Res
, vol.70
-
-
Leyland-Jones, B.1
Regan, M.M.2
Bouzyk, M.3
Kammler, R.4
Tang, W.5
Pagani, O.6
Malbach, R.7
Dell'Orto, P.8
Thürlimann, B.9
Price, K.N.10
Viale, G.11
-
28
-
-
77955556907
-
Cytochrome P450 2D6 and outcomes of adjuvant tamoxifen therapy: results of a meta-analysis
-
Seruga B, Amir E. Cytochrome P450 2D6 and outcomes of adjuvant tamoxifen therapy: results of a meta-analysis. Breast Cancer Res Treat 2010; 122: 609-17.
-
(2010)
Breast Cancer Res Treat
, vol.122
, pp. 609-617
-
-
Seruga, B.1
Amir, E.2
-
29
-
-
45749083522
-
Pharmacokinetics/genotype associations for major cytochrome P450 enzymes in native and first- and third-generation Japanese populations: comparison with Korean, Chinese, and Caucasian populations
-
Myrand SP, Sekiguchi K, Man MZ, Lin X, Tzeng RY, Teng CH, Hee B, Garrett M, Kikkawa H, Lin CY, Eddy SM, Dostalik J, Mount J, Azuma J, Fujio Y, Jang IJ, Shin SG, Bleavins MR, Williams JA, Paulauskis JD, Wilner KD. Pharmacokinetics/genotype associations for major cytochrome P450 enzymes in native and first- and third-generation Japanese populations: comparison with Korean, Chinese, and Caucasian populations. Clin Pharmacol Ther 2008; 84: 347-61.
-
(2008)
Clin Pharmacol Ther
, vol.84
, pp. 347-361
-
-
Myrand, S.P.1
Sekiguchi, K.2
Man, M.Z.3
Lin, X.4
Tzeng, R.Y.5
Teng, C.H.6
Hee, B.7
Garrett, M.8
Kikkawa, H.9
Lin, C.Y.10
Eddy, S.M.11
Dostalik, J.12
Mount, J.13
Azuma, J.14
Fujio, Y.15
Jang, I.J.16
Shin, S.G.17
Bleavins, M.R.18
Williams, J.A.19
Paulauskis, J.D.20
Wilner, K.D.21
more..
-
30
-
-
77952521444
-
Effect of concomitant CYP2D6 inhibitor use and tamoxifen adherence on breast cancer recurrence in early-stage breast cancer
-
Dezentjé VO, van Blijderveen NJ, Gelderblom H, Putter H, van Herk-Sukel MP, Casparie MK, Egberts AC, Nortier JW, Guchelaar HJ. Effect of concomitant CYP2D6 inhibitor use and tamoxifen adherence on breast cancer recurrence in early-stage breast cancer. J Clin Oncol 2010; 28: 2423-9.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2423-2429
-
-
Dezentjé, V.O.1
van Blijderveen, N.J.2
Gelderblom, H.3
Putter, H.4
van Herk-Sukel, M.P.5
Casparie, M.K.6
Egberts, A.C.7
Nortier, J.W.8
Guchelaar, H.J.9
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