-
1
-
-
19344364880
-
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials
-
Early Breast Cancer Trialists' Collaborative Group
-
Early Breast Cancer Trialists' Collaborative Group. (2005) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet, 365, 1687-1717.
-
(2005)
Lancet
, vol.365
, pp. 1687-1717
-
-
-
2
-
-
0032537396
-
Tamoxifen for early breast cancer: an overview of the randomised trials Early Breast Cancer Trialists' Collaborative Group
-
Early Breast Cancer Trialists' Collaborative Group
-
Early Breast Cancer Trialists' Collaborative Group. (1998) Tamoxifen for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group. Lancet, 351, 1451-1467.
-
(1998)
Lancet
, vol.351
, pp. 1451-1467
-
-
-
3
-
-
0019411776
-
Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues
-
Borgna, J.L. and Rochefort, H. (1981) Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues. J. Biol. Chem., 256, 859-868.
-
(1981)
J. Biol. Chem.
, vol.256
, pp. 859-868
-
-
Borgna, J.L.1
Rochefort, H.2
-
4
-
-
0024584001
-
Distribution of 4-hydroxy-N-desmethyltamoxifen and other tamoxifen metabolites in human biological fluids during tamoxifen treatment
-
Lien, E.A., Solheim, E., Lea, O.A., Lundgren, S., Kvinnsland, S. and Ueland, P.M. (1989) Distribution of 4-hydroxy-N-desmethyltamoxifen and other tamoxifen metabolites in human biological fluids during tamoxifen treatment. Cancer Res., 49, 2175-2183.
-
(1989)
Cancer Res
, vol.49
, pp. 2175-2183
-
-
Lien, E.A.1
Solheim, E.2
Lea, O.A.3
Lundgren, S.4
Kvinnsland, S.5
Ueland, P.M.6
-
5
-
-
3342932419
-
Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen
-
Johnson, M.D., Zuo, H., Lee, K.H., Trebley, J.P., Rae, J.M., Weatherman, R.V., Desta, Z., Flockhart, D.A. and Skaar, T.C. (2004) Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen. Breast Cancer Res. Treat., 85, 151-159.
-
(2004)
Breast Cancer Res. Treat.
, vol.85
, pp. 151-159
-
-
Johnson, M.D.1
Zuo, H.2
Lee, K.H.3
Trebley, J.P.4
Rae, J.M.5
Weatherman, R.V.6
Desta, Z.7
Flockhart, D.A.8
Skaar, T.C.9
-
6
-
-
43649090742
-
Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy
-
Kiyotani, K., Mushiroda, T., Sasa, M., Bando, Y., Sumitomo, I., Hosono, N., Kubo, M., Nakamura, Y. and Zembutsu, H. (2008) Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy. Cancer Sci., 99, 995-999.
-
(2008)
Cancer Sci
, vol.99
, pp. 995-999
-
-
Kiyotani, K.1
Mushiroda, T.2
Sasa, M.3
Bando, Y.4
Sumitomo, I.5
Hosono, N.6
Kubo, M.7
Nakamura, Y.8
Zembutsu, H.9
-
7
-
-
77950502100
-
Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients
-
Kiyotani, K., Mushiroda, T., Imamura, C.K., Hosono, N., Tsunoda, T., Kubo, M., Tanigawara, Y., Flockhart, D.A., Desta, Z., Skaar, T.C. et al. (2010) Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients. J. Clin. Oncol., 28, 1287-1293.
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 1287-1293
-
-
Kiyotani, K.1
Mushiroda, T.2
Imamura, C.K.3
Hosono, N.4
Tsunoda, T.5
Kubo, M.6
Tanigawara, Y.7
Flockhart, D.A.8
Desta, Z.9
Skaar, T.C.10
-
8
-
-
33644639136
-
Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes
-
Goetz, M.P., Rae, J.M., Suman, V.J., Safgren, S.L., Ames, M.M., Visscher, D.W., Reynolds, C., Couch, F.J., Lingle, W.L., Flockhart, D.A. et al. (2005) Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. J. Clin. Oncol., 23, 9312-9318.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 9312-9318
-
-
Goetz, M.P.1
Rae, J.M.2
Suman, V.J.3
Safgren, S.L.4
Ames, M.M.5
Visscher, D.W.6
Reynolds, C.7
Couch, F.J.8
Lingle, W.L.9
Flockhart, D.A.10
-
9
-
-
33847034287
-
The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen
-
Goetz, M.P., Knox, S.K., Suman, V.J., Rae, J.M., Safgren, S.L., Ames, M.M., Visscher, D.W., Reynolds, C., Couch, F.J., Lingle, W.L. et al. (2007) The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen. Breast Cancer Res. Treat., 101, 113-121.
-
(2007)
Breast Cancer Res. Treat.
, vol.101
, pp. 113-121
-
-
Goetz, M.P.1
Knox, S.K.2
Suman, V.J.3
Rae, J.M.4
Safgren, S.L.5
Ames, M.M.6
Visscher, D.W.7
Reynolds, C.8
Couch, F.J.9
Lingle, W.L.10
-
10
-
-
36349024762
-
Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes
-
Schroth, W., Antoniadou, L., Fritz, P., Schwab, M., Muerdter, T., Zanger, U.M., Simon, W., Eichelbaum, M. and Brauch, H. (2007) Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes. J. Clin. Oncol., 25, 5187-5193.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 5187-5193
-
-
Schroth, W.1
Antoniadou, L.2
Fritz, P.3
Schwab, M.4
Muerdter, T.5
Zanger, U.M.6
Simon, W.7
Eichelbaum, M.8
Brauch, H.9
-
11
-
-
34548532227
-
Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer
-
Lim, H.S., Lee, J.H., Lee, S.K., Lee, S.E., Jang, I.J. and Ro, J. (2007) Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer. J. Clin. Oncol., 25, 3837-3845.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 3837-3845
-
-
Lim, H.S.1
Lee, J.H.2
Lee, S.K.3
Lee, S.E.4
Jang, I.J.5
Ro, J.6
-
12
-
-
47749105202
-
Association between CYP2D6*10 genotype and survival of breast cancer patients receiving tamoxifen treatment
-
Xu, Y., Sun, Y., Yao, L., Shi, L., Wu, Y., Ouyang, T., Li, J., Wang, T., Fan, Z., Fan, T. et al. (2008) Association between CYP2D6*10 genotype and survival of breast cancer patients receiving tamoxifen treatment. Ann. Oncol., 19, 1423-1429.
-
(2008)
Ann. Oncol.
, vol.19
, pp. 1423-1429
-
-
Xu, Y.1
Sun, Y.2
Yao, L.3
Shi, L.4
Wu, Y.5
Ouyang, T.6
Li, J.7
Wang, T.8
Fan, Z.9
Fan, T.10
-
13
-
-
19944434201
-
CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment
-
Jin, Y., Desta, Z., Stearns, V., Ward, B., Ho, H., Lee, K.H., Skaar, T., Storniolo, A.M., Li, L., Araba, A. et al. (2005) CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment. J. Natl Cancer Inst., 97, 30-39.
-
(2005)
J. Natl Cancer Inst.
, vol.97
, pp. 30-39
-
-
Jin, Y.1
Desta, Z.2
Stearns, V.3
Ward, B.4
Ho, H.5
Lee, K.H.6
Skaar, T.7
Storniolo, A.M.8
Li, L.9
Araba, A.10
-
14
-
-
77953679656
-
Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer
-
Gjerde, J., Geisler, J., Lundgren, S., Ekse, D., Varhaug, J.E., Mellgren, G., Steen, V.M. and Lien, E.A. (2010) Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer. BMC Cancer, 10, 313.
-
(2010)
BMC Cancer
, vol.10
, pp. 313
-
-
Gjerde, J.1
Geisler, J.2
Lundgren, S.3
Ekse, D.4
Varhaug, J.E.5
Mellgren, G.6
Steen, V.M.7
Lien, E.A.8
-
15
-
-
70349929431
-
Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen
-
Schroth, W., Goetz, M.P., Hamann, U., Fasching, P.A., Schmidt, M., Winter, S., Fritz, P., Simon, W., Suman, V.J., Ames, M.M. et al. (2009) Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen. J. Am. Med. Assoc., 302, 1429-1436.
-
(2009)
J. Am. Med. Assoc.
, vol.302
, pp. 1429-1436
-
-
Schroth, W.1
Goetz, M.P.2
Hamann, U.3
Fasching, P.A.4
Schmidt, M.5
Winter, S.6
Fritz, P.7
Simon, W.8
Suman, V.J.9
Ames, M.M.10
-
16
-
-
34248208754
-
Genetic variants of CYP3A5, CYP2D6, SULT1A1 UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer
-
Wegman, P., Elingarami, S., Carstensen, J., Stal, O., Nordenskjold, B. and Wingren, S. (2007) Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer. Breast Cancer Res., 9, R7.
-
(2007)
Breast Cancer Res
, vol.9
-
-
Wegman, P.1
Elingarami, S.2
Carstensen, J.3
Stal, O.4
Nordenskjold, B.5
Wingren, S.6
-
17
-
-
2542542256
-
Ultraconserved elements in the human genome
-
Bejerano, G., Pheasant, M., Makunin, I., Stephen, S., Kent, W.J., Mattick, J.S. and Haussler, D. (2004) Ultraconserved elements in the human genome. Science, 304, 1321-1325.
-
(2004)
Science
, vol.304
, pp. 1321-1325
-
-
Bejerano, G.1
Pheasant, M.2
Makunin, I.3
Stephen, S.4
Kent, W.J.5
Mattick, J.S.6
Haussler, D.7
-
18
-
-
2642538502
-
The DNA sequence and comparative analysis of human chromosome 10
-
Deloukas, P., Earthrowl, M.E., Grafham, D.V., Rubenfield, M., French, L., Steward, C.A., Sims, S.K., Jones, M.C., Searle, S., Scott, C. et al. (2004) The DNA sequence and comparative analysis of human chromosome 10. Nature, 429, 375-381.
-
(2004)
Nature
, vol.429
, pp. 375-381
-
-
Deloukas, P.1
Earthrowl, M.E.2
Grafham, D.V.3
Rubenfield, M.4
French, L.5
Steward, C.A.6
Sims, S.K.7
Jones, M.C.8
Searle, S.9
Scott, C.10
-
19
-
-
33845906629
-
Ancient noncoding elements conserved in the human genome
-
Venkatesh, B., Kirkness, E.F., Loh, Y.H., Halpern, A.L., Lee, A.P., Johnson, J., Dandona, N., Viswanathan, L.D., Tay, A., Venter, J.C. et al. (2006) Ancient noncoding elements conserved in the human genome. Science, 314, 1892.
-
(2006)
Science
, vol.314
, pp. 1892
-
-
Venkatesh, B.1
Kirkness, E.F.2
Loh, Y.H.3
Halpern, A.L.4
Lee, A.P.5
Johnson, J.6
Dandona, N.7
Viswanathan, L.D.8
Tay, A.9
Venter, J.C.10
-
20
-
-
57349113761
-
Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen
-
Hurtado, A., Holmes, K.A., Geistlinger, T.R., Hutcheson, I.R., Nicholson, R.I., Brown, M., Jiang, J., Howat, W.J., Ali, S. and Carroll, J.S. (2008) Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen. Nature, 456, 663-666.
-
(2008)
Nature
, vol.456
, pp. 663-666
-
-
Hurtado, A.1
Holmes, K.A.2
Geistlinger, T.R.3
Hutcheson, I.R.4
Nicholson, R.I.5
Brown, M.6
Jiang, J.7
Howat, W.J.8
Ali, S.9
Carroll, J.S.10
-
21
-
-
40749094918
-
SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis
-
Han, H.J., Russo, J., Kohwi, Y. and Kohwi-Shigematsu, T. (2008) SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis. Nature, 452, 187-193.
-
(2008)
Nature
, vol.452
, pp. 187-193
-
-
Han, H.J.1
Russo, J.2
Kohwi, Y.3
Kohwi-Shigematsu, T.4
-
22
-
-
58149163446
-
Tissue-specific genetic control of splicing: implications for the study of complex traits
-
Heinzen, E.L., Ge, D., Cronin, K.D., Maia, J.M., Shianna, K.V., Gabriel, W.N., Welsh-Bohmer, K.A., Hulette, C.M., Denny, T.N. and Goldstein, D.B. (2008) Tissue-specific genetic control of splicing: implications for the study of complex traits. PLoS Biol, 6, e1.
-
(2008)
PLoS Biol
, vol.6
-
-
Heinzen, E.L.1
Ge, D.2
Cronin, K.D.3
Maia, J.M.4
Shianna, K.V.5
Gabriel, W.N.6
Welsh-Bohmer, K.A.7
Hulette, C.M.8
Denny, T.N.9
Goldstein, D.B.10
-
23
-
-
77955924464
-
Lessons for pharmacogenomics studies: association study between CYP2D6 genotype and tamoxifen response
-
Kiyotani, K., Mushiroda, T., Hosono, N., Tsunoda, T., Kubo, M., Aki, F., Okazaki, Y., Hirata, K., Takatsuka, Y., Okazaki, M. et al. (2010) Lessons for pharmacogenomics studies: association study between CYP2D6 genotype and tamoxifen response. Pharmacogenet. Genomics, 20, 565-568.
-
(2010)
Pharmacogenet. Genomics
, vol.20
, pp. 565-568
-
-
Kiyotani, K.1
Mushiroda, T.2
Hosono, N.3
Tsunoda, T.4
Kubo, M.5
Aki, F.6
Okazaki, Y.7
Hirata, K.8
Takatsuka, Y.9
Okazaki, M.10
-
24
-
-
57149102096
-
A polymorphism in the TC21 promoter associates with an unfavorable tamoxifen treatment outcome in breast cancer
-
Rokavec, M., Schroth, W., Amaral, S.M., Fritz, P., Antoniadou, L., Glavac, D., Simon, W., Schwab, M., Eichelbaum, M. and Brauch, H. (2008) A polymorphism in the TC21 promoter associates with an unfavorable tamoxifen treatment outcome in breast cancer. Cancer Res., 68, 9799-9808.
-
(2008)
Cancer Res
, vol.68
, pp. 9799-9808
-
-
Rokavec, M.1
Schroth, W.2
Amaral, S.M.3
Fritz, P.4
Antoniadou, L.5
Glavac, D.6
Simon, W.7
Schwab, M.8
Eichelbaum, M.9
Brauch, H.10
-
25
-
-
36849043530
-
Quantitative justification of the change from 10% to 30% for human epidermal growth factor receptor 2 scoring in the American Society of Clinical Oncology/College of American Pathologists Guidelines: tumor heterogeneity in breast cancer and its implications for tissue microarray based assessment of outcome
-
Moeder, C.B., Giltnane, J.M., Harigopal, M., Molinaro, A., Robinson, A., Gelmon, K., Huntsman, D., Camp, R.L. and Rimm, D.L. (2007) Quantitative justification of the change from 10% to 30% for human epidermal growth factor receptor 2 scoring in the American Society of Clinical Oncology/College of American Pathologists Guidelines: tumor heterogeneity in breast cancer and its implications for tissue microarray based assessment of outcome. J. Clin. Oncol., 25, 5418-5425.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 5418-5425
-
-
Moeder, C.B.1
Giltnane, J.M.2
Harigopal, M.3
Molinaro, A.4
Robinson, A.5
Gelmon, K.6
Huntsman, D.7
Camp, R.L.8
Rimm, D.L.9
-
26
-
-
0034885541
-
A high-throughput SNP typing system for genome-wide association studies
-
Ohnishi, Y., Tanaka, T., Ozaki, K., Yamada, R., Suzuki, H. and Nakamura, Y. (2001) A high-throughput SNP typing system for genome-wide association studies. J. Hum. Genet., 46, 471-477.
-
(2001)
J. Hum. Genet.
, vol.46
, pp. 471-477
-
-
Ohnishi, Y.1
Tanaka, T.2
Ozaki, K.3
Yamada, R.4
Suzuki, H.5
Nakamura, Y.6
-
27
-
-
35348983887
-
A second generation human haplotype map of over 3.1 million SNPs
-
Frazer, K.A., Ballinger, D.G., Cox, D.R., Hinds, D.A., Stuve, L.L., Gibbs, R.A., Belmont, J.W., Boudreau, A., Hardenbol, P., Leal, S.M. et al. (2007) A second generation human haplotype map of over 3.1 million SNPs. Nature, 449, 851-861.
-
(2007)
Nature
, vol.449
, pp. 851-861
-
-
Frazer, K.A.1
Ballinger, D.G.2
Cox, D.R.3
Hinds, D.A.4
Stuve, L.L.5
Gibbs, R.A.6
Belmont, J.W.7
Boudreau, A.8
Hardenbol, P.9
Leal, S.M.10
-
28
-
-
13444269543
-
Haploview: analysis and visualization of LD and haplotype maps
-
Barrett, J.C., Fry, B., Maller, J. and Daly, M.J. (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics, 21, 263-265.
-
(2005)
Bioinformatics
, vol.21
, pp. 263-265
-
-
Barrett, J.C.1
Fry, B.2
Maller, J.3
Daly, M.J.4
-
29
-
-
68149149465
-
CYP2D6 genotyping for functional-gene dosage analysis by allele copy number detection
-
Hosono, N., Kato, M., Kiyotani, K., Mushiroda, T., Takata, S., Sato, H., Amitani, H., Tsuchiya, Y., Yamazaki, K., Tsunoda, T. et al. (2009) CYP2D6 genotyping for functional-gene dosage analysis by allele copy number detection. Clin. Chem., 55, 1546-1554.
-
(2009)
Clin. Chem.
, vol.55
, pp. 1546-1554
-
-
Hosono, N.1
Kato, M.2
Kiyotani, K.3
Mushiroda, T.4
Takata, S.5
Sato, H.6
Amitani, H.7
Tsuchiya, Y.8
Yamazaki, K.9
Tsunoda, T.10
-
30
-
-
43649103816
-
Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia
-
Kiyotani, K., Mushiroda, T., Kubo, M., Zembutsu, H., Sugiyama, Y. and Nakamura, Y. (2008) Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia. Cancer Sci., 99, 967-972.
-
(2008)
Cancer Sci
, vol.99
, pp. 967-972
-
-
Kiyotani, K.1
Mushiroda, T.2
Kubo, M.3
Zembutsu, H.4
Sugiyama, Y.5
Nakamura, Y.6
-
31
-
-
0032714352
-
Genomic control for association studies
-
Devlin, B. and Roeder, K. (1999) Genomic control for association studies. Biometrics, 55, 997-1004.
-
(1999)
Biometrics
, vol.55
, pp. 997-1004
-
-
Devlin, B.1
Roeder, K.2
|