Associations between serotonin transporter gene polymorphisms and heat pain perception in adults with chronic pain

BMC Medical Genetics

Volumn 14, Issue 1, 2013, Pages

  Hooten, W Michael ^a   Hartman, William R ^a   Black III, John Logan ^a   Laures, Heidi J ^a   Walker, Denise L ^a  

^a Mayo Clinic College of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE; OPIATE; SEROTONIN TRANSPORTER;

ADULT; ADULTHOOD; ARTICLE; CHRONIC PAIN; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; GENOTYPE; HEAT; HUMAN; MAJOR CLINICAL STUDY; MALE; NOCICEPTION; OUTPATIENT CARE; REHABILITATION CARE;

ALLELES; CHRONIC PAIN; COHORT STUDIES; FEMALE; GENOTYPE; HOT TEMPERATURE; HUMANS; MALE; PAIN PERCEPTION; PAIN THRESHOLD; POLYMORPHISM, SINGLE NUCLEOTIDE; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEX FACTORS;

EID: 84880909477     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-14-78     Document Type: Article

References (58)

1. Daws LC, Gould GG. Ontogeny and regulation of the serotonin transporter: providing insights into human disorders. Pharmacol Ther 2011, 131:61-79. 10.1016/j.pharmthera.2011.03.013, 3131109, 21447358.
2. Heils A, Teufel A, Petri S, Stober G, Riederer P, et al. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996, 66:2621-2624.
3. Ramamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, et al. Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci USA 1993, 90:2542-2546. 10.1073/pnas.90.6.2542, 46124, 7681602.
4. Hu X, Oroszi G, Chun J, Smith TL, Goldman D, et al. An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcohol Clin Exp Res 2005, 29:8-16. 10.1097/01.ALC.0000150008.68473.62, 15654286.
5. Wendland JR, Martin BJ, Kruse MR, Lesch KP, Murphy DL. Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry 2006, 11:224-226. 10.1038/sj.mp.4001789, 16402131.
6. Murphy DL, Lesch KP. Targeting the murine serotonin transporter: insights into human neurobiology. Nat Rev Neurosci 2008, 9:85-96.
7. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996, 274:1527-1531. 10.1126/science.274.5292.1527, 8929413.
8. Palm F, Mossner R, Chen Y, He L, Gerlach M, et al. Reduced thermal hyperalgesia and enhanced peripheral nerve injury after hind paw inflammation in mice lacking the serotonin-transporter. Eur J Pain 2008, 12:790-797. 10.1016/j.ejpain.2007.11.009, 18187350.
9. Vogel C, Mossner R, Gerlach M, Heinemann T, Murphy DL, et al. Absence of thermal hyperalgesia in serotonin transporter-deficient mice. J Neurosci 2003, 23:708-715.
10. Kosek E, Jensen KB, Lonsdorf TB, Schalling M, Ingvar M. Genetic variation in the serotonin transporter gene (5-HTTLPR, rs25531) influences the analgesic response to the short acting opioid remifentanil in humans. Mol Pain 2009, 5:37. 10.1186/1744-8069-5-37, 2717925, 19570226.
11. Lindstedt F, Berrebi J, Greayer E, Lonsdorf TB, Schalling M, et al. Conditioned pain modulation is associated with common polymorphisms in the serotonin transporter gene. PLoS One 2011, 6:e18252. 10.1371/journal.pone.0018252, 3065474, 21464942.
12. Lindstedt F, Lonsdorf TB, Schalling M, Kosek E, Ingvar M. Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene. PLoS One 2011, 6:e17752. 10.1371/journal.pone.0017752, 3057988, 21423614.
13. Potvin S, Larouche A, Normand E, de Souza JB, Gaumond I, et al. No relationship between the ins del polymorphism of the serotonin transporter promoter and pain perception in fibromyalgia patients and healthy controls. Eur J Pain 2010, 14:742-746. 10.1016/j.ejpain.2009.12.004, 20080425.
14. Treister R, Pud D, Ebstein RP, Laiba E, Raz Y, et al. Association between polymorphisms in serotonin and dopamine-related genes and endogenous pain modulation. J Pain 2011, 12:875-883. 10.1016/j.jpain.2011.02.348, 21719351.
15. Hooten WM, Mantilla CB, Sandroni P, Townsend CO Associations between heat pain perception and opioid dose among patients with chronic pain undergoing opioid tapering. Pain Med 2010, 11:1587-1598. 10.1111/j.1526-4637.2010.00962.x, 21029354, Townsend CO.
16. Hooten WM, Sandroni P, Mantilla CB, Townsend CO Associations between heat pain perception and pain severity among patients with chronic pain. Pain Med 2010, 11:1554-1563. 10.1111/j.1526-4637.2010.00940.x, 20807344, Townsend CO.
17. Rolke R, Baron R, Maier C, Tolle TR, Treede RD, et al. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. Pain 2006, 123:231-243. 10.1016/j.pain.2006.01.041, 16697110.
18. Townsend CO, Bruce BK, Hooten WM, Rome JD. The role of mental health professionals in multidisciplinary pain rehabilitation programs. J Clin Psychol 2006, 62:1433-1443. 10.1002/jclp.20322, 16937355.
19. Cunningham JL, Rome JD, Kerkvliet JL, Townsend CO Reduction in medication costs for patients with chronic nonmalignant pain completing a pain rehabilitation program: a prospective analysis of admission, discharge, and 6-month follow-up medication costs. Pain Med 2009, 10:787-796. 10.1111/j.1526-4637.2009.00582.x, 19302437, Townsend CO.
20. DuPen S, DuPen A. Opioid conversion calculator 2000, Poulsbo, WA: Cynergy Group.
21. Hooten WM, Bruce BK, Warner DO, Townsend CO The effects of smoking status on opioid tapering among patients with chronic pain. Anesth Analg 2009, 108:308-315. 10.1213/ane.0b013e31818c7b99, 19095867, Townsend CO.
22. Kerkvliet JL, Bruce BK, Rome JD, Michael Hooten W, , et al. Townsend CO A longitudinal study of the efficacy of a comprehensive pain rehabilitation program with opioid withdrawal: comparison of treatment outcomes based on opioid use status at admission. Pain 2008, 140:177-189. 10.1016/j.pain.2008.08.005, 18804915, Townsend CO.
23. Kerns RD, Turk DC, Rudy TE. The West Haven-Yale Multidimensional Pain Inventory (WHYMPI). Pain 1985, 23:345-356. 10.1016/0304-3959(85)90004-1, 4088697.
24. Bernstein IH, Jaremko ME, Hinkley BS. On the utility of the West haven-yale multidimensional pain inventory. Spine 1995, 20:956-963. Phila Pa 1976, 10.1097/00007632-199504150-00014, 7644962.
25. Rudy TE, Rudy TE. Multiaxial assessment of multidimensional pain inventory: computer program User's manual 1989, Pittsburgh, PA: University of Pittsburgh.
26. Dyck PJ, Zimmerman IR, O'Brien PC, Ness A, Caskey PE, et al. Introduction of automated systems to evaluate touch-pressure, vibration, and thermal cutaneous sensation in man. Ann Neurol 1978, 4:502-510. 10.1002/ana.410040605, 742850.
27. Dyck PJ, Zimmerman I, Gillen DA, Johnson D, Karnes JL, et al. Cool, warm, and heat-pain detection thresholds: testing methods and inferences about anatomic distribution of receptors. Neurology 1993, 43:1500-1508. 10.1212/WNL.43.8.1500, 8351002.
28. Dyck PJ, Zimmerman IR, Johnson DM, Gillen D, Hokanson JL, et al. A standard test of heat-pain responses using CASE IV. J Neurol Sci 1996, 136:54-63. 10.1016/0022-510X(95)00277-9, 8815179.
29. O'Brien PC, Dyck PJ. Procedures for setting normal values. Neurology 1995, 45:17-23. 10.1212/WNL.45.1.17, 7824110.
30. Dyck PJ, O'Brien PC, Litchy WJ, Harper CM, Daube JR. Use of percentiles and normal deviates to express nerve conduction and other test abnormalities. Muscle Nerve 2001, 24:307-310. 10.1002/1097-4598(200103)24:3<307::AID-MUS1000>3.0.CO;2-A, 11353414.
31. Dyck PJ, O'Brien PC, Kosanke JL, Gillen DA, Karnes JL. A 4, 2, and 1 stepping algorithm for quick and accurate estimation of cutaneous sensation threshold. Neurology 1993, 43:1508-1512. 10.1212/WNL.43.8.1508, 8351003.
32. Wendland JR, Moya PR, Kruse MR, Ren-Patterson RF, Jensen CL, et al. A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder. Hum Mol Genet 2008, 17:717-723.
33. Weir BS. Genetic data analysis II: methods for discrete population genetic data 1997, Sunderland, MA: Sinauer Associates, Incorporated Publishers.
34. Sommer C. Serotonin in pain and analgesia: actions in the periphery. Mol Neurobiol 2004, 30:117-125. 10.1385/MN:30:2:117, 15475622.
35. Lang PM, Moalem-Taylor G, Tracey DJ, Bostock H, Grafe P. Activity-dependent modulation of axonal excitability in unmyelinated peripheral rat nerve fibers by the 5-HT(3) serotonin receptor. J Neurophysiol 2006, 96:2963-2971. 10.1152/jn.00716.2006, 16956988.
36. Lischetzki G, Rukwied R, Handwerker HO, Schmelz M. Nociceptor activation and protein extravasation induced by inflammatory mediators in human skin. Eur J Pain 2001, 5:49-57.
37. Ernberg M, Lundeberg T, Kopp S. Pain and allodynia/hyperalgesia induced by intramuscular injection of serotonin in patients with fibromyalgia and healthy individuals. Pain 2000, 85:31-39. 10.1016/S0304-3959(99)00233-X, 10692600.
38. Vanegas H, Schaible HG. Descending control of persistent pain: inhibitory or facilitatory?. Brain Res Brain Res Rev 2004, 46:295-309. 10.1016/j.brainresrev.2004.07.004, 15571771.
39. Liu FY, Qu XX, Ding X, Cai J, Jiang H, et al. Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation. Brain Res 2010, 1330:45-60.
40. Sounvoravong S, Nakashima MN, Wada M, Nakashima K. Decrease in serotonin concentration in raphe magnus nucleus and attenuation of morphine analgesia in two mice models of neuropathic pain. Eur J Pharmacol 2004, 484:217-223. 10.1016/j.ejphar.2003.11.028, 14744606.
41. Palazzo E, Genovese R, Mariani L, Siniscalco D, Marabese I, et al. Metabotropic glutamate receptor 5 and dorsal raphe serotonin release in inflammatory pain in rat. Eur J Pharmacol 2004, 492:169-176. 10.1016/j.ejphar.2004.03.063, 15178361.
42. Zhang YQ, Gao X, Zhang LM, Wu GC. The release of serotonin in rat spinal dorsal horn and periaqueductal gray following carrageenan inflammation. Neuroreport 2000, 11:3539-3543. 10.1097/00001756-200011090-00027, 11095514.
43. Zeitz KP, Guy N, Malmberg AB, Dirajlal S, Martin WJ, et al. The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. J Neurosci 2002, 22:1010-1019.
44. Silveira JW, Dias QM, Del Bel EA, Prado WA. Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats. Mol Pain 2010, 6:17. 10.1186/1744-8069-6-17, 2860347, 20331882.
45. Liu XY, Wu SX, Wang YY, Wang W, Zhou L, et al. Changes of 5-HT receptor subtype mRNAs in rat dorsal root ganglion by bee venom-induced inflammatory pain. Neurosci Lett 2005, 375:42-46. 10.1016/j.neulet.2004.10.064, 15664120.
46. Wu S, Zhu M, Wang W, Wang Y, Li Y, et al. Changes of the expression of 5-HT receptor subtype mRNAs in rat dorsal root ganglion by complete Freund's adjuvant-induced inflammation. Neurosci Lett 2001, 307:183-186. 10.1016/S0304-3940(01)01946-2, 11438394.
47. Hains BC, Everhart AW, Fullwood SD, Hulsebosch CE. Changes in serotonin, serotonin transporter expression and serotonin denervation supersensitivity: involvement in chronic central pain after spinal hemisection in the rat. Exp Neurol 2002, 175:347-362. 10.1006/exnr.2002.7892, 12061865.
48. Rolke R, Magerl W, Campbell KA, Schalber C, Caspari S, et al. Quantitative sensory testing: a comprehensive protocol for clinical trials. Eur J Pain 2006, 10:77-88. 10.1016/j.ejpain.2005.02.003, 16291301.
49. Wasner GL, Brock JA. Determinants of thermal pain thresholds in normal subjects. Clin Neurophysiol 2008, 119:2389-2395. 10.1016/j.clinph.2008.07.223, 18778969.
50. Offenbaecher M, Bondy B, de Jonge S, Glatzeder K, Kruger M, et al. Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region. Arthritis Rheum 1999, 42:2482-2488. 10.1002/1529-0131(199911)42:11<2482::AID-ANR27>3.0.CO;2-B, 10555044.
51. Cohen H, Buskila D, Neumann L, Ebstein RP. Confirmation of an association between fibromyalgia and serotonin transporter promoter region (5- HTTLPR) polymorphism, and relationship to anxiety-related personality traits. Arthritis Rheum 2002, 46:845-847.
52. Gursoy S. Absence of association of the serotonin transporter gene polymorphism with the mentally healthy subset of fibromyalgia patients. Clin Rheumatol 2002, 21:194-197. 10.1007/s10067-002-8284-5, 12111622.
53. Park JW, Kim JS, Kim YI, Lee KS. Serotonergic activity contributes to analgesic overuse in chronic tension-type headache. Headache 2005, 45:1229-1235. 10.1111/j.1526-4610.2005.00247.x, 16178954.
54. Cevoli S, Marzocchi N, Capellari S, Scapoli C, Pierangeli G, et al. Lack of association between five serotonin metabolism-related genes and medication overuse headache. J Headache Pain 2010, 11:53-58. 10.1007/s10194-009-0168-5, 3452189, 19936617.
55. Kotani K, Shimomura T, Shimomura F, Ikawa S, Nanba E. A polymorphism in the serotonin transporter gene regulatory region and frequency of migraine attacks. Headache 2002, 42:893-895. 10.1046/j.1526-4610.2002.02209.x, 12390616.
56. Liu H, Liu M, Wang Y, Wang XM, Qiu Y, et al. Association of 5-HTT gene polymorphisms with migraine: a systematic review and meta-analysis. J Neurol Sci 2011, 305:57-66. 10.1016/j.jns.2011.03.016, 21450309.
57. Palit S, Sheaff RJ, France CR, McGlone ST, Potter WT, et al. Serotonin transporter gene (5-HTTLPR) polymorphisms are associated with emotional modulation of pain but not emotional modulation of spinal nociception. Biol Psychol 2011, 86:360-369. 10.1016/j.biopsycho.2011.01.008, 21291949.
58. Watkins EA, Wollan PC, Melton LJ, Yawn BP. A population in pain: report from the Olmsted county health study. Pain Med 2008, 9:166-174. 10.1111/j.1526-4637.2007.00280.x, 18298699.