AlCl3-mediated hydroarylation–heteroarylation in a single pot: A direct access to densely functionalized olefins of pharmacological interest

Chemical Communications

Volumn 49, Issue 56, 2013, Pages 6268-6270

  Nakhi, Ali ^a   Archana, Sivakumar ^a,b   Seerapu, Guru Pavan Kumar ^a   Chennubhotla, Keerthana Sarma ^a   Kumar, Kummari Lalith ^a   Kulkarni, Pushkar ^a   Haldar, Devyani ^a   Pal, Manojit ^a  

^a UNIVERSITY OF HYDERABAD   (India)

^b MANIPAL COLLEGE OF PHARMACEUTICAL SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENE; ALUMINUM CHLORIDE; ALUMINUM DERIVATIVE; ANTINEOPLASTIC AGENT; CHLORIDE; ENZYME INHIBITOR; QUINOXALINE DERIVATIVE; SIRTUIN; POLYCYCLIC AROMATIC HYDROCARBON; PROTEIN INHIBITOR; SPLITOMICIN; UNCLASSIFIED DRUG; 2 (2,2 DIARYLVINYL) 3 ARYLQUINOXALINE; ALKYNE;

ANIMAL; ANIMAL EMBRYO; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE; ZEBRA FISH; ANIMAL EXPERIMENT; ARTICLE; ARYLATION; CANCER INHIBITION; CELL STRAIN HEPG2; CHEMICAL BOND; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; HETEROARYLATION; HUMAN CELL; HYDROARYLATION; IC 50; ISOMERISM; NONHUMAN; ONE POT SYNTHESIS; COVALENT BOND; HYDROGEN BOND; LIVER CELL CARCINOMA; NUCLEOPHILICITY;

ALKENES; ALUMINUM COMPOUNDS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHLORIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; EMBRYO, NONMAMMALIAN; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUINOXALINES; SIRTUINS; STRUCTURE-ACTIVITY RELATIONSHIP; ZEBRAFISH;

EID: 84880866076     PISSN: 13597345     EISSN: 1364548X     Source Type: Journal    
DOI: 10.1039/c3cc42840k     Document Type: Article

References (18)

1. R. R. Schrock, Angew. Chem., Int. Ed., 2006, 45, 3748.
2. R. H. Grubbs, Angew. Chem., Int. Ed., 2006, 45, 3760.
3. V. C. Jordan, Nat. Rev. Drug Discovery, 2003, 2, 205.
4. K. S. Kumar, P. M. Kumar, K. A. Kumar, M. Sreenivasulu, A. A. Jafar, D. Rambabu, G. R. Krishna, C. M. Reddy, R. Kapavarapu, K. S. Kumar, K. K. Priya, K. V. L. Parsa, M. Pal, Chem. Commun., 2011, 47, 5010.
5. K. S. Kumar, P. M. Kumar, M. A. Reddy, M. Ferozuddin, M. Sreenivasulu, A. A. Jafar, G. R. Krishna, C. M. Reddy, D. Rambabu, K. S. Kumar, S. Pal, M. Pal, Chem. Commun., 2011, 47, 10263.
6. P. M. Kumar, K. S. Kumar, P. K. Mohakhud, K. Mukkanti, R. Kapavarapu, K. V. L. Parsa, M. Pal, Chem. Commun., 2012, 48, 431.
7. R. Adepu, R. Sunke, C. L. T. Meda, D. Rambabu, G. R. Krishna, C. M. Reddy, G. S. Deora, K. V. L. Parsa, M. Pal, Chem. Commun., 2013, 49, 190.
8. S. Michan, D. Sinclair, Biochem. J., 2007, 404, 1.
9. A. Bedalov, T. Gatbonton, W. P. Irvine, D. E. Gottschling, J. A. Simon, Proc. Natl. Acad. Sci. U. S. A., 2001, 98, 15113.
10. M. Pal, R. Dakarapu, K. Parasuraman, V. Subramanian, J. Org. Chem., 2005, 70, 7179.
11. C. Nevado, A. M. Echavarren, Synthesis, 2005, 167.
12. X. Wang, L. Zhou, W. Lu, Curr. Org. Chem., 2010, 14, 289.
13. T. Kitamura, Eur. J. Org. Chem., 2009, 1111.
14. T. Tsuchimoto, T. Maeda, E. Shirakawa, Y. Kawakami, Chem. Commun., 2000, 1573.
15. C. E. Song, D.-u. Jung, S. Y. Choung, E. J. Roh, S.-G. Lee, Angew. Chem., Int. Ed., 2004, 43, 6183.
16. M. Pal, V. R. Batchu, K. Parasuraman, K. R. Yeleswarapu, J. Org. Chem., 2003, 68, 6806.
17. M. Pal, V. R. Batchu, I. Dager, N. K. Swamy, S. Padakanti, J. Org. Chem., 2005, 70, 2376.
18. C. M. Grozinger, E. D. Chao, H. E. Blackwell, D. Moazed, S. L. Schreiber, J. Biol. Chem., 2001, 276, 38837.