Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors

Cancer Research

Volumn 73, Issue 14, 2013, Pages 4190-4195

  Dutta, Prasanta ^a   Le, Anne ^b   Vander Jagt, David L ^d   Tsukamoto, Takashi ^c   Martinez, Gary V ^a   Dang, Chi V ^e   Gillies, Robert J ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b Sol Goldman Pancreatic Cancer Research Center   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; BIS 2 (5 PHENYLACETAMIDO 1,2,4 DIATHIAZOL 2 YL)ETHYL SULFIDE; FX 11; GLUTAMINASE; GLUTAMINASE INHIBITOR; HYDROLASE INHIBITOR; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE A INHIBITOR; LACTATE DEHYDROGENASE ISOENZYME 5; LACTIC ACID; OXIDOREDUCTASE INHIBITOR; PYRUVIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B CELL LYMPHOMA; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG RESPONSE; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; TUMOR XENOGRAFT;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; B-LYMPHOCYTES; CARBON ISOTOPES; CELL LINE, TUMOR; GLUTAMINASE; HUMANS; ISOENZYMES; L-LACTATE DEHYDROGENASE; LACTIC ACID; LYMPHOMA; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; PYRUVIC ACID; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84880855809     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-13-0465     Document Type: Article

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