Color doppler ultrasound and gamma imaging of intratumorally injected 500 nm iron-silica nanoshells

ACS Nano

Volumn 7, Issue 7, 2013, Pages 6367-6377

  Liberman, Alexander ^a   Wu, Zhe ^b   Barback, Christopher V ^b   Viveros, Robert ^c   Blair, Sarah L ^d   Ellies, Lesley G ^e   Vera, David R ^b   Mattrey, Robert F ^b   Kummel, Andrew C ^a   Trogler, William C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

biodistribution; nanoparticles; scintigraphy; silica; ultrasound

Indexed keywords

BIODISTRIBUTIONS; COLOR DOPPLER ULTRASOUNDS; DIETHYLENETRIAMINE PENTA-ACETIC ACIDS; INTRATUMORAL INJECTION; LIVER ACCUMULATION; SCINTIGRAPHY; SILICA NANOPARTICLES; ULTRASOUND CONTRAST AGENT;

DOPPLER EFFECT; MAMMALS; NANOPARTICLES; NANOSTRUCTURED MATERIALS; NANOSTRUCTURES; NON NEWTONIAN FLOW; NUCLEAR MEDICINE; RADIATION; RADIOACTIVITY; SILICA; TUMORS; ULTRASONICS;

NANOSHELLS;

INDIUM; IRON; NANOPARTICLE; PENTETIC ACID; RADIOPHARMACEUTICAL AGENT; SILICON DIOXIDE; DIAGNOSTIC AGENT;

ANIMAL; CHEMISTRY; COLOR ULTRASOUND FLOWMETRY; DIAGNOSTIC USE; INTRALESIONAL DRUG ADMINISTRATION; MOUSE; NEOPLASMS, EXPERIMENTAL; NUDE MOUSE; PROCEDURES; SCINTISCANNING; TUMOR CELL LINE; ARTICLE; EXPERIMENTAL NEOPLASM; METHODOLOGY;

ANIMALS; CELL LINE, TUMOR; INDIUM RADIOISOTOPES; INJECTIONS, INTRALESIONAL; IRON; MICE; MICE, NUDE; NANOPARTICLES; NEOPLASMS, EXPERIMENTAL; PENTETIC ACID; RADIONUCLIDE IMAGING; RADIOPHARMACEUTICALS; SILICON DIOXIDE; ULTRASONOGRAPHY, DOPPLER, COLOR;

EID: 84880836730     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn402507d     Document Type: Article

References (53)

1. Couleaud, P.; Morosini, V.; Frochot, C.; Richeter, S.; Raehm, L.; Durand, J.-O. Silica-Based Nanoparticles for Photodynamic Therapy Applications Nanoscale 2010, 2, 1083-1095
2. Lebret, V.; Raehm, L.; Durand, J.-O.; Smaihi, M.; Werts, M. H. V.; Blanchard-Desce, M.; Methy-Gonnod, D.; Dubernet, C. Folic Acid-Targeted Mesoporous Silica Nanoparticles for Two-Photon Fluorescence J. Biomed. Nanotechnol. 2010, 6, 176-180
3. Rieter, W. J.; Kim, J. S.; Taylor, K. M. L.; An, H.; Lin, W.; Tarrant, T.; Lin, W. Hybrid Silica Nanoparticles for Multimodal Imaging Angew. Chem., Int. Ed. 2007, 46, 3680-3682
4. Lin, Y.-S.; Hung, Y.; Su, J.-K.; Lee, R.; Chang, C.; Lin, M.-L.; Mou, C.-Y. Gadolinium(III)-Incorporated Nanosized Mesoporous Silica as Potential Magnetic Resonance Imaging Contrast Agents J. Phys. Chem. B 2004, 108, 15608-15611
5. Hsiao, J.-K.; Tsai, C.-P.; Chung, T.-H.; Hung, Y.; Yao, M.; Liu, H.-M.; Mou, C.-Y.; Yang, C.-S.; Chen, Y.-C.; Huang, D.-M. Mesoporous Silica Nanoparticles as a Delivery System of Gadolinium for Effective Human Stem Cell Tracking Small 2008, 4, 1445-1452
6. Yang, J.; Sandoval, S.; Alfaro, J. G.; Aschemeyer, S.; Liberman, A.; Martin, D. T.; Makale, M.; Kummel, A. C.; Trogler, W. C. Red-Luminescent Europium (III) Doped Silica Nanoshells: Synthesis, Characterization, and their Interaction with HeLa Cells J. Biomed. Opt. 2011, 16, 066012
7. Lu, J.; Liong, M.; Li, Z.; Zink, J. I.; Tamanoi, F. Biocompatibility, Biodistribution, and Drug-Delivery Efficiency of Mesoporous Silica Nanoparticles for Cancer Therapy in Animals Small 2010, 6, 1794-1805
8. Liberman, A.; Martinez, H. P.; Ta, C. N.; Barback, C. V.; Mattrey, R. F.; Kono, Y.; Blair, S. L.; Trogler, W. C.; Kummel, A. C.; Wu, Z. Hollow Silica and Silica-Boron Nano/Microparticles for Contrast-Enhanced Ultrasound to Detect Small Tumors Biomaterials 2012, 33, 5124-5129
9. Martinez, H. P.; Kono, Y.; Blair, S. L.; Sandoval, S.; Wang-Rodriguez, J.; Mattrey, R. F.; Kummel, A. C.; Trogler, W. C. Hard Shell Gas-Filled Contrast Enhancement Particles for Colour Doppler Ultrasound Imaging of Tumors Medchemcomm 2010, 1, 266-270
10. Ta, C. N.; Liberman, A.; Paul Martinez, H.; Barback, C. V.; Mattrey, R. F.; Blair, S. L.; Trogler, W. C.; Kummel, A. C.; Wu, Z. Integrated Processing of Contrast Pulse Sequencing Ultrasound Imaging for Enhanced Active Contrast of Hollow Gas Filled Silica Nanoshells and Microshells J. Vac. Sci. Technol., B 2012, 30, 02C104-02C104-6
11. Wang, X.; Chen, H.; Chen, Y.; Ma, M.; Zhang, K.; Li, F.; Zheng, Y.; Zeng, D.; Wang, Q.; Shi, J. Perfluorohexane-Encapsulated Mesoporous Silica Nanocapsules as Enhancement Agents for Highly Efficient High Intensity Focused Ultrasound (HIFU) Adv. Mater. 2012, 24, 785-791
12. Hu, H.; Zhou, H.; Du, J.; Wang, Z.; An, L.; Yang, H.; Li, F.; Wu, H.; Yang, S. Biocompatiable Hollow Silica Microspheres as Novel Ultrasound Contrast Agents for in Vivo Imaging J. Mater. Chem. 2011, 21, 6576-6583
13. Lin, P.-L.; Eckersley, R. J.; Hall, E. A. H. Ultrabubble: A Laminated Ultrasound Contrast Agent with Narrow Size Range Adv. Mater. 2009, 21, 3949-3952
14. Krekel, N.; Zonderhuis, B.; Muller, S.; Bril, H.; van Slooten, H.-J.; de Lange de Klerk, E.; van den Tol, P.; Meijer, S. Excessive Resections in Breast-Conserving Surgery: A Retrospective Multicentre Study Breast 2011, 17, 602-609
15. Rahusen, F. D.; Bremers, A. J. A.; Fabry, H. F. J.; Taets van Amerongen, A. H. M.; Boom, R. P. A.; Meijer, S. Ultrasound-Guided Lumpectomy of Nonpalpable Breast Cancer versus Wire-Guided Resection: A Randomized Clinical Trial Ann. Surg. Oncol. 2002, 9, 994-998
16. Gray, R. J.; Pockaj, B. A.; Karstaedt, P. J.; Roarke, M. C. Radioactive Seed Localization of Nonpalpable Breast Lesions Is Better than Wire Localization Am. J. Surg. 2004, 188, 377-380
17. Hughes, J. H.; Mason, M. C.; Gray, R. J.; McLaughlin, S. A.; Degnim, A. C.; Fulmer, J. T.; Pockaj, B. A.; Karstaedt, P. J.; Roarke, M. C.; Multi-site, A. Validation Trial of Radioactive Seed Localization as an Alternative to Wire Localization Breast 2008, 14, 153-157
18. Regelsberger, J.; Lohmann, F.; Helmke, K.; Westphal, M. Ultrasound-Guided Surgery of Deep Seated Brain Lesions Eur. J. Ultrasound 2000, 12, 115-121
19. Torzilli, G.; Takayama, T.; Hui, A.-M.; Kubota, K.; Harihara, Y.; Makuuchi, M. A New Technical Aspect of Ultrasound-Guided Liver Surgery Am. J. Surg. 1999, 178, 341-343
20. Harlow, S. P.; Krag, D. N.; Ames, S. E.; Weaver, D. L. Intraoperative Ultrasound Localization to Guide Surgical Excision of Nonpalpable Breast Carcinoma J. Am. Coll. Surg. 1999, 189, 241-246
21. Dogan, B. E.; Whitman, G. J. Intraoperative Breast Ultrasound Semin. Roentgenol. 2011, 46, 280-284
22. Han, J. S.; Molberg, K. H.; Sarode, V. Predictors of Invasion and Axillary Lymph Node Metastasis in Patients with a Core Biopsy Diagnosis of Ductal Carcinoma in Situ: An Analysis of 255 Cases Breast 2011, 17, 223-229
23. He, X.; Nie, H.; Wang, K.; Tan, W.; Wu, X.; Zhang, P. In Vivo Study of Biodistribution and Urinary Excretion of Surface-Modified Silica Nanoparticles Anal. Chem. 2008, 80, 9597-9603
24. Liu, T.; Li, L.; Teng, X.; Huang, X.; Liu, H.; Chen, D.; Ren, J.; He, J.; Tang, F. Single and Repeated Dose Toxicity of Mesoporous Hollow Silica Nanoparticles in Intravenously Exposed Mice Biomaterials 2011, 32, 1657-1668
25. Decuzzi, P.; Godin, B.; Tanaka, T.; Lee, S. Y.; Chiappini, C.; Liu, X.; Ferrari, M. Size and Shape Effects in the Biodistribution of Intravascularly Injected Particles J. Controlled Release 2010, 141, 320-327
26. Kommareddy, S.; Amiji, M. Biodistribution and Pharmacokinetic Analysis of Long-Circulating Thiolated Gelatin Nanoparticles Following Systemic Administration in Breast Cancer-Bearing Mice J. Pharm. Sci. 2007, 96, 397-407
27. Zhang, R.; Xiong, C.; Huang, M.; Zhou, M.; Huang, Q.; Wen, X.; Liang, D.; Li, C. Peptide-Conjugated Polymeric Micellar Nanoparticles for Dual SPECT and Optical Imaging of EphB4 Receptors in Prostate Cancer Xenografts Biomaterials 2011, 32, 5872-5879
28. Melancon, M. P.; Lu, W.; Yang, Z.; Zhang, R.; Cheng, Z.; Elliot, A. M.; Stafford, J.; Olson, T.; Zhang, J. Z.; Li, C. In Vitro and In Vivo Targeting of Hollow Gold Nanoshells Directed at Epidermal Growth Factor Receptor for Photothermal Ablation Therapy Mol. Cancer Ther. 2008, 7, 1730-1739
29. Tsai, C.-P.; Hung, Y.; Chou, Y.-H.; Huang, D.-M.; Hsiao, J.-K.; Chang, C.; Chen, Y.-C.; Mou, C.-Y. High-Contrast Paramagnetic Fluorescent Mesoporous Silica Nanorods as a Multifunctional Cell-Imaging Probe Small 2008, 4, 186-191
30. Mitchell, K. K. P., Iron(III)-Doped, Silica: Biodegradable, Self-Targeting Nanoparticles. UCSD: 2011; Vol. Thesis Dissertation.
31. Pohaku Mitchell, K. K.; Liberman, A.; Kummel, A. C.; Trogler, W. C. Iron(III)-Doped, Silica Nanoshells: A Biodegradable Form of Silica J. Am. Chem. Soc. 2012, 134, 13997-14003
32. Yu, T.; Malugin, A.; Ghandehari, H. Impact of Silica Nanoparticle Design on Cellular Toxicity and Hemolytic Activity ACS Nano 2011, 5, 5717-5728
33. Hermanson, G. Bioconjugate Techniques; Academic Press: San Diego, CA, 1996.
34. Kobler, J.; Möller, K.; Bein, T. Colloidal Suspensions of Functionalized Mesoporous Silica Nanoparticles ACS Nano 2008, 2, 791-799
35. Ng, C. P.; Pun, S. H. A Perfusable 3D Cell-Matrix Tissue Culture Chamber for in Situ Evaluation of Nanoparticle Vehicle Penetration and Transport Biotechnol. Bioeng. 2008, 99, 1490-1501
36. Longmire, M.; Choyke, P. L.; Kobayashi, H. Clearance Properties of Nano-Sized Particles and Molecules as Imaging Agents: Considerations and Caveats Nanomedicine 2008, 3, 703-717
37. 111In-DTPA To Accelerate Clearance from Non-Target Organs and Blood Int. J. Rad. Appl. Instrum. B. 1989, 16, 475-481
38. 3+ Complexes of DTPA Amide Derivatives: Biodistribution and Clearance Studied by Gamma Imaging Nucl. Med. Biol. 2000, 27, 605-610
39. Li, C.; Yu, D.-F.; Inoue, T.; Yang, D. J.; Tansey, W.; Liu, C.-W.; Milas, L.; Hunter, N. R.; Kim, E. E.; Wallace, S. Synthesis, Biodistribution and Imaging Properties of Indium-111-DTPA-Paclitaxel in Mice Bearing Mammary Tumors J. Nucl. Med. 1997, 38, 1042-1047
40. 111In-Chloride: A New Agent for Bone Marrow Imaging J. Nucl. Med. 1973, 14, 184-186
41. Maeda, H.; Wu, J.; Sawa, T.; Matsumura, Y.; Hori, K. Tumor Vascular Permeability and the EPR Effect in Macromolecular Therapeutics: A Review J. Controlled Release 2000, 65, 271-284
42. Son, Y. J.; Jang, J.-S.; Cho, Y. W.; Chung, H.; Park, R.-W.; Kwon, I. C.; Kim, I.-S.; Park, J. Y.; Seo, S. B.; Park, C. R. et al. Biodistribution and Anti-Tumor Efficacy of Doxorubicin Loaded Glycol-Chitosan Nanoaggregates by EPR Effect J. Controlled Release 2003, 91, 135-145
43. Davis, M. E.; Chen, Z.; Shin, D. M. Nanoparticle Therapeutics: An Emerging Treatment Modality for Cancer Nat. Rev. Drug Discov. 2008, 7, 771-782
44. Lee, A.; Chick, J. M.; Kolarich, D.; Haynes, P. A.; Robertson, G. R.; Tsoli, M.; Jankova, L.; Clarke, S. J.; Packer, N. H.; Baker, M. S., Liver Membrane Proteome Glycosylation Changes in Mice Bearing an Extra-Hepatic Tumor. Mol. Cell. Proteomics 2011, 10.
45. Kacevska, M.; Downes, M. R.; Sharma, R.; Evans, R. M.; Clarke, S. J.; Liddle, C.; Robertson, G. R. Extrahepatic Cancer Suppresses Nuclear Receptor-Regulated Drug Metabolism Clin. Cancer. Res. 2011, 17, 3170-3180
46. Kacevska, M.; Mahns, A.; Sharma, R.; Clarke, S.; Robertson, G.; Liddle, C. Extra-Hepatic Cancer Represses Hepatic Drug Metabolism via Interleukin (IL)-6 Signalling Pharm. Res. 2013, 1-9
47. Sharma, R.; Kacevska, M.; London, R.; Clarke, S. J.; Liddle, C.; Robertson, G. Downregulation of Drug Transport and Metabolism in Mice Bearing Extra-Hepatic Malignancies Br. J. Cancer 2007, 98, 91-97
48. Kacevska, M.; Robertson, G. R.; Clarke, S. J.; Liddle, C. Inflammation and CYP3A4-Mediated Drug Metabolism in Advanced Cancer: Impact and Implications for Chemotherapeutic Drug Dosing Expert Opin Drug Metab Toxicol 2008, 4, 137-149
49. Hogemann-Savellano, D.; Bos, E.; Blondet, C.; Sato, F.; Abe, T.; Josephson, L.; Weissleder, R.; Gaudet, J.; Sgroi, D.; Peters, P. J. The Transferrin Receptor: A Potential Molecular Imaging Marker for Human Cancer Neoplasia 2003, 5, 495-506
50. Shindelman, J. E.; Ortmeyer, A. E.; Sussman, H. H. Demonstration of the Transferrin Receptor in Human Breast Cancer Tissue. Potential Marker for Identifying Dividing Cells Int. J. Cancer 1981, 27, 329-334
51. Page Faulk, W.; Hsi, B.-L.; Stevens, P. J. Transferrin and Transferrin Receptors in Carcinoma of the Breast Lancet 1980, 316, 390-392
52. Nguyen, Q. T.; Olson, E. S.; Aguilera, T. A.; Jiang, T.; Scadeng, M.; Ellies, L. G.; Tsien, R. Y. Surgery with Molecular Fluorescence Imaging Using Activatable Cell-Penetrating Peptides Decreases Residual Cancer and Improves Survival Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 4317-4322
53. Yang, J.; Lind, J. U.; Trogler, W. C. Synthesis of Hollow Silica and Titania Nanospheres Chem. Mater. 2008, 20, 2875-2877