Microparticles prepared from biodegradable polyhydroxyalkanoates as matrix for encapsulation of cytostatic drug

Journal of Materials Science: Materials in Medicine

Volumn 24, Issue 8, 2013, Pages 1905-1915

  Murueva, A V ^a,b   Shishatskaya, E I ^a,b   Kuzmina, A M ^b   Volova, T G ^a,b   Sinskey, A J ^c  

^a INSTITUTE OF BIOPHYSICS   (Russian Federation)

^b SIBERIAN FEDERAL UNIVERSITY   (Russian Federation)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3-HYDROXYBUTYRIC ACID; AVERAGE DIAMETER; CELL ATTACHMENTS; CHEMICAL COMPOSITIONS; MASS CONCENTRATION; MOUSE-FIBROBLASTS; POLYHYDROXYALKANOATES; SOLVENT EVAPORATION TECHNIQUES;

BIOCOMPATIBILITY; CELL CULTURE; CELLS;

LOADING;

3 HYDROXYBUTYRIC ACID; 3 HYDROXYHEXANOIC ACID; 4 HYDROXYBUTYRIC ACID; 4',6 DIAMIDINO 2 PHENYLINDOLE; DNA; DOXORUBICIN; NANOPARTICLE; POLYHYDROXYALKANOIC ACID; POLYMER; POLYSTYRENE; SOLVENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOCOMPATIBILITY; BIODEGRADABILITY; CELL ADHESION; CELL PROLIFERATION; CELL STRAIN 3T3; CELL VIABILITY; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG RELEASE; ELECTROPHORETIC MOBILITY; ENCAPSULATION; EVAPORATION; FIBROBLAST; IN VITRO STUDY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; STAIN; STUDY; SURFACE CHARGE; ZETA POTENTIAL;

ABSORBABLE IMPLANTS; ANIMALS; CYTOSTATIC AGENTS; DOXORUBICIN; DRUG CARRIERS; DRUG COMPOUNDING; DRUG EVALUATION, PRECLINICAL; MATERIALS TESTING; MICE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; MODELS, BIOLOGICAL; NIH 3T3 CELLS; PARTICLE SIZE; POLYHYDROXYALKANOATES; POLYMERS;

EID: 84880836523     PISSN: 09574530     EISSN: 15734838     Source Type: Journal    
DOI: 10.1007/s10856-013-4941-2     Document Type: Article

References (36)

1. Dutta RC. Drug carriers in pharmaceutical design: promises and progress. Curr Pharm Des. 2007;13:761-9.
2. Freiberg S, Zhu X. Polymer microspheres for controlled drug release. Int J Pharm. 2004;282:1-18.
3. Jain K. Drug delivery systems - an overview. In: Jain KK, editor. Drug delivery systems. USA: Humana Press; 2009. p. 1-50.
4. Volova TG. Microbial polyhydroxyalkanoates - plastic materials of the 21st century (biosynthesis, properties, applications). NY: Nova Science Pub. Inc.; 2004. p. 282.
5. Volova TG, Sevastianov VI, Shyshatskaya EI. Polyhydroxyalkanoates - biodestructible polymers for medicine. Krasnoyarsk: Platina; 2006. p. 288.
6. Sudesh K, Abe H, Doi Y. Synthesis, structure and properties of polyhydroxyalkanoates: biological polyesters. Prog Polym Sci. 2000;25:1503-55.
7. Ueda H, Tabata Y. Polyhydroxyalkanonate derivatives in current clinical applications and trials. Adv Drug Deliv Rev. 2003;55:501-18.
8. Salman MA, Sahin A, Onur MA. Tramadol encapsulated into polyhydroxybutirate microspheres: in vitro release and epidural analgetic effect in rats. Acta Anaesthesiol Scand. 2003;47:1006-12.
9. Lionzo M, Re M, Guterres S. Pohlmann microparticles prepared with poly(hydroxybutyrate-co-hydroxyvalerate) and poly(ε-caprolactone) blends to control the release of a drug model. J Microencapsul. 2007;24:175-86.
10. Bazzo G, et al. Effect of preparation conditions on morphology, drug content and release profiles of poly(hydroxybutyrate) microparticles containing piroxicam. J Braz Chem Soc. 2008;19:914-21.
11. Bidone J, et al. Preparation and characterization of ibuprofen-loaded microspheres consisting of poly(3-hydroxybutyrate) and metoxy poly (ethylene glycol)-b-poly (d, l-lactide) blends or poly(3-hydroxybuturate) and gelatine composites for controlled drug release. Mater Sci Eng. 2009;29:588-93.
12. Zawidlak-Wegrzyńska B, et al. Synthesis and antiproliferative properties of ibuprofen-oligo(3-hydroxybutyrate) conjugates. Eur J Med Chem. 2010;45:1833-42.
13. Lu B, Wang ZR, Yang H. Long-acting delivery microsheres of levo-norgesterol- poly(3-hydroxybutirate): their preparation, characterization and contraceptive tests on mice. J Microencapsul. 2001;18:55-64.
14. Rossi S, Azghani A, Omri A. Antimicrobal efficacy of a new antibiotic-loaded poly(hydroxybutyric-co-hydroxyvaleric acid) controlled release system. J Antimicrob Chem. 2004;54:1013-8.
15. Duran N, et al. Microencapsulation of antibiotic rifampicin in poly(3-hydroxybutyrate-co3- hydroxyvalerate). Arch Pharm Res. 2008;31:1509-16.
16. Zhang C, et al. Folate-mediated poly(3-hydroxybutyrate-co-3- hydroxyoctanoate) nanoparticles for targeting drug delivery. Eur J Pharm Biopharm. 2010;76:10-6.
17. Shishatskaya EI, Chlusov IA, Volova TG. A hybrid PHA-hydroxyapatite composite for biomedical application: production and investigation. J Biomater Sci Polym Ed. 2006;17(5):481-98.
18. Shishatskaya EI. Biomedical investigation, application of PHA. Macromol Symp. 2008;269:65-81.
19. Livshits VA, Bonartsev AP, Iordansky AL. Microspheres poly(3-hydroxybutyrate) for prolonged release of drugs. Vysokomol Soedin. 2009;51:1243-51 (in Russian).
20. Goreva AV, Shishatskaya EI, Volova TG. Characterization of polymeric microparticles based on resorbable polyesters of oxyalkanoic acids as a platform for deposition and delivery of drugs. Vysokomol Soedin. 2012;54(2):224-36 (in Russian).
21. Nakaoka R, Tsuchiya T. Biocompatibility of various kinds of polymeric microspheres estimated from their effect on gap junctional intercellular communication of fibroblasts. Mater Trans. 2002;43(12):3122-7.
22. Soppimatha KS, et al. Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release. 2001;70:1-20.
23. Vasil'ev E, et al. Transdermal therapeutic systems for controlled drug release. Khim Farm Zh. 2001;35(11):29-42 (in Russian).
24. Maia L, Santana M. The effect of some processing conditions on the characteristics of biodegradable microspheres obtained by an emulsion solvent evaporation process. Braz J Chem Eng. 2004;21:1-12.
25. Embelton JK, Tighe BJ. Polymers for biodegradable medical devices. X: microincapsulation studies: control of polyhydroxybutyrate-hydroxyvalerate microcapsule porosity via polycaprolactone blending. Biomaterials. 1993;10(3):341-52.
26. Khang G, et al. Preparation and characterization of poly(3- hydroxybutirate-co-3-hydroxyvalerate) microspheres for the sustained release of 5-fluorouracil. Biomed Mater Eng. 2001;11:89-103.
27. Huang W, et al. A novel PHBV/HA microsphere releasing system loaded with alendronate. Mater Sci Eng. 2009;29:2221-5.
28. Lu X, et al. Sustained release of PI3 K inhibitor from PHA nanoparticles and in vitro growth inhibition of cancer cell lines. Appl Microbiol Biotechnol. 2011;89:1423-33.
29. Shah M, et al. Amphiphilic PHA-mPEG copolymeric nanocontainers for drug delivery: preparation, characterization and in vivo evaluation. Inter J Pharm. 2010;400:165-75.
30. Yu JJ, et al. Biodistribution and anti-tumor efficacy of PEG/PLA nanoparticles loaded doxorubicin. J Drug Target. 2007;15(4):279-84.
31. de Sanchez Juan B. Cytotoxicity of doxorubicin bound to poly(butyl cyanoacrylate) nanoparticles in rat glioma cell lines using different assays. J Drug Target. 2006;14(9):614-22.
32. Lee Y, et al. MMPs-specific PEGylated peptide-DOX conjugate micelles that can contain free doxorubicin. Eur J Pharm Biopharm. 2007;67:646-54.
33. Furgenson D, Dreher M, Chilkoti A. Structural optimization of a "smart" doxorubicin-polypeptide conjugate for thermally targeted delivery to solid tumors. J Control Release. 2006;110:362-9.
34. Cheng X, et al. DNA/chitosan nanocomplex as a novel drug carrier for doxorubicin. Drug Deliv. 2009;16:135-44.
35. Kim J, Kabanov A, Bronich T. Polymer micelles with cross-linked polyanion core for delivery of a cationic drug doxorubicin. J Control Release. 2009;138:197-204.
36. Lee H, Chang J. Preparation, characterization and in vitro release of gentamicin from PHBV/wollastonite composite microspheres. J Control Release. 2005;107:463-73.