Phaseoloideside E, a novel natural triterpenoid saponin identified from entada phaseoloides, induces apoptosis in Ec-109 esophageal cancer cells through reactive oxygen species generation

Journal of Pharmacological Sciences

Volumn 122, Issue 3, 2013, Pages 163-175

  Mo, Shasha ^a   Xiong, Hui ^a   Shu, Guangwen ^a   Yang, Xinzhou ^a   Wang, Jianxia ^a   Zheng, Congyi ^b   Xiong, Wei ^b   Mei, Zhinan ^a  

^a SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

Apoptosis; Entada phaseoloides; Esophageal cancer; Natural compound; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 9; CISPLATIN; GLUTATHIONE; PHASEOLOIDESIDE E; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SAPONIN DERIVATIVE; SUPEROXIDE DISMUTASE; TRITERPENOID; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE G1 PHASE; CELL DEATH; CELL STRUCTURE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; ENTADA PHASEOLOIDES; ENZYME ACTIVITY; ESOPHAGUS CANCER; ESOPHAGUS CARCINOMA; HERB; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; SEED KERNEL; UPREGULATION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 9; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ESOPHAGEAL NEOPLASMS; FABACEAE; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; MICE; PHYTOTHERAPY; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SAPONINS; TRITERPENES; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 84880826386     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.12193FP     Document Type: Article

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