The Expression of TMPRSS4 and Erk1 Correlates with Metastasis and Poor Prognosis in Chinese Patients with Gastric Cancer

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Luo, Zu Yan ^a   Wang, Yuan Yu ^a   Zhao, Zhong Sheng ^a   Li, Bo ^a   Chen, Jun Fa ^a  

^a ZHEJIANG PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; SERINE PROTEINASE; TRANSMEMBRAN PROTEASE SERINE 4; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; AGE; AGED; ARTICLE; CANCER CLASSIFICATION; CANCER GROWTH; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CHINESE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISTANT METASTASIS; ENZYME ACTIVATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS; PROTEIN EXPRESSION; REGIONAL METASTASIS; STOMACH CANCER; SURVIVAL RATE; SURVIVAL TIME; TUMOR INVASION; TUMOR VOLUME; UPREGULATION;

AGED; DISEASE PROGRESSION; FEMALE; GASTRIC MUCOSA; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOPLASM METASTASIS; NEOPLASM STAGING; PROGNOSIS; SERINE ENDOPEPTIDASES; STOMACH NEOPLASMS;

EID: 84880823474     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070311     Document Type: Article

References (23)

1. Hooper JD, Clements JA, Quigley JP, Antalis TM, (2001) Type II transmembrane serine proteases. Insights into an emerging class of cell surface proteolytic enzymes. J Biol Chem 276: 857-860.
2. Netzel-Arnett S, Hooper JD, Szabo R, Madison EL, Quigley JP, et al. (2003) Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer. Cancer Metastasis Rev 22: 237-258.
3. Wallrapp C, Hähnel S, Müller-Pillasch F, Burghardt B, Iwamura T, et al. (2000) A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer. Cancer Res 60: 2602-2606.
4. Kebebew E, Peng M, Reiff E, Duh QY, Clark OH, et al. (2005) ECM1 and TMPRSS4 are diagnostic markers of malignant thyroid neoplasms and improve the accuracy of fine needle aspiration biopsy. Ann Surg 242: 353-361.
5. Kim S, Kang HY, Nam EH, Choi MS, Zhao XF, et al. (2010) TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin alpha5 and its signaling pathways. Carcinogenesis 31: 597-606.
6. Lu Z, Xu S, (2006) ERK1/2 MAP kinases in cell survival and apoptosis. IUBMB Life 58: 621-631.
7. Lee HS, Lee HK, Kim HS, Yang HK, Kim WH, (2003) Tumour suppressor gene expression correlates with gastric cancer prognosis. J Pathol 200: 39-46.
8. Lee HS, Lee HK, Kim HS, Yang HK, Kim YI, et al. (2001) MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas: their roles as prognostic indicators. Cancer 92: 1427-1434.
9. Zhang D, Salto-Tellez M, Putti TC, Do E, Koay ES, (2003) Reliability of tissue microarrays in detecting protein expression and gene amplification in breast cancer. Mod Pathol 16: 79-84.
10. Lee HS, Cho SB, Lee HE, Kim MA, Kim JH, et al. (2007) Protein expression profiling and molecular classification of gastric cancer by the tissue array method. Clin Cancer Res 13: 4154-4163.
11. Kolev Y, Uetake H, Iida S, Ishikawa T, Kawano T, et al. (2007) Prognostic significance of VEGF expression in correlation with COX-2, microvessel density and clinicopathological characteristics in human gastric carcinoma. Annals of Surgical Oncology 14: 2738-2747.
12. Mizokami K, Kakeji Y, Oda S, Irie K, Yonemura T, et al. (2006) Clinicopathologic significance of hypoxia-inducible factor 1 alpha overexpression in gastric carcinomas. Journal of Surgical Oncology 94: 149-154.
13. Song LB, Liao WT, Mai HQ, Zhang HZ, Zhang L, et al. (2006) The clinical significance of twist expression in nasopharyngeal carcinoma. Cancer Lett 242: 258-265.
14. Chou YY, Jeng YM, Lee TT, Hu FC, Kao HL, et al. (2007) Cytoplasmic CD24 expression is a novel prognostic factor in diffuse-type gastric adenocarcinoma. Ann Surg Oncol 14: 2748-2758.
15. Szabo R, Bugge TH, (2008) Type II transmembrane serine proteases in development and disease.Int J Biochem Cell Biol. 40: 1297-1316.
16. Antalis TM, Bugge TH, Wu Q, (2011) Membrane-anchored serine proteases in health and disease.Prog Mol Biol Transl Sci. 99: 1-50.
17. Jarzab B, Wiench M, Fujarewicz K, Simek K, Jarzab M, et al. (2005) Gene expression profile of papillary thyroid cancer: sources of variability and diagnostic implications. Cancer Res 65: 1587-1597.
18. Jung H, Lee KP, Park SJ, Park JH, Jang YS, et al. (2008) TMPRSS4 promotes invasion, migration and metastasis of human tumor cells by facilitating an epithelial-mesenchymal transition. Oncogene 27: 2635-2647.
19. Li T, Zeng ZC, Wang L, Qiu SJ, Zhou JW, et al. (2011) Radiation enhances long-term metastasis potential of residual hepatocellular carcinoma in nude mice through TMPRSS4-induced epithelial-mesenchymal transition. Cancer Gene Ther 18: 617-626.
20. Larzabal L, Nguewa PA, Pio R, Blanco D, Sanchez B, et al. (2011) Overexpression of TMPRSS4 in non-small cell lung cancer is associated with poor prognosis in patients with squamous histology. Br J Cancer 105: 1608-1614.
21. Mao J, Xu Z, Fang Y, Wang H, Xu J, et al. (2008) Hepatoma-derived growth factor involved in the carcinogenesis of gastric epithelial cells through promotion of cell proliferation by Erk1/2 activation. Cancer Sci 99: 2120-2127.
22. Ramachandran S, Shida D, Nagahashi M, Fang X, Milstien S, et al. (2010) Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription. FEBS Lett 584: 4077-4082.
23. Guo D, Zhou H, Wu Y, Zhou F, Xu G, et al. (2011) Involvement of ERK1/2/NF-κB signal transduction pathway in TF/FVIIa/PAR2-induced proliferation and migration of colon cancer cell SW620. Tumour Biol 32: 921-930.