-
1
-
-
33646201684
-
Functional bowel disorders
-
Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology. 2006;130: 1480-1491.
-
(2006)
Gastroenterology
, vol.130
, pp. 1480-1491
-
-
Longstreth, G.F.1
Thompson, W.G.2
Chey, W.D.3
Houghton, L.A.4
Mearin, F.5
Spiller, R.C.6
-
2
-
-
33646204796
-
Fundamentals of neurogastroenterology: Basic science
-
Grundy D, Al-Chaer ED, Aziz Q, et al. Fundamentals of neurogastroenterology: basic science. Gastroenterology. 2006;130: 1391-1411.
-
(2006)
Gastroenterology
, vol.130
, pp. 1391-1411
-
-
Grundy, D.1
Al-Chaer, E.D.2
Aziz, Q.3
-
3
-
-
0036008323
-
Effects of tachykinin NK1 receptor antagonists on the viscerosensory response caused by colorectal distention in rabbits
-
Okano S, Ikeura Y, Inatomi N. Effects of tachykinin NK1 receptor antagonists on the viscerosensory response caused by colorectal distention in rabbits. J Pharmacol Exp Ther. 2002;300:925-931.
-
(2002)
J Pharmacol Exp Ther
, vol.300
, pp. 925-931
-
-
Okano, S.1
Ikeura, Y.2
Inatomi, N.3
-
4
-
-
18344362026
-
4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl) ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine hydrochloride (SSR125543A): A potent and selective corticotrophin-releasing factor(1) receptor antagonist. I. Biochemical and pharmacological characterization
-
Gully D, Geslin M, Serva L, et al. 4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl) ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine hydrochloride (SSR125543A): a potent and selective corticotrophin-releasing factor(1) receptor antagonist. I. Biochemical and pharmacological characterization. J Pharmacol Exp Ther. 2002;301:322-332.
-
(2002)
J Pharmacol Exp Ther
, vol.301
, pp. 322-332
-
-
Gully, D.1
Geslin, M.2
Serva, L.3
-
5
-
-
34547223476
-
Evaluation of the pharmacological profile of ramosetron, a novel therapeutic agent for irritable bowel syndrome
-
Hirata T, Keto Y, Funatsu T, Akuzawa S, Sasamata M. Evaluation of the pharmacological profile of ramosetron, a novel therapeutic agent for irritable bowel syndrome. J Pharmacol Sci. 2007;104: 263-273.
-
(2007)
J Pharmacol Sci
, vol.104
, pp. 263-273
-
-
Hirata, T.1
Keto, Y.2
Funatsu, T.3
Akuzawa, S.4
Sasamata, M.5
-
6
-
-
0026970064
-
Characterization of YMO60, a potent and selective 5-hydroxytryptamine 3 receptor antagonist, in rabbit nodose ganglion and NIE-115 neuroblastoma cells
-
Ito H, Hidaka K, Miyata K, Kamato T, Nishida A, Honda K. Characterization of YMO60, a potent and selective 5-hydroxytryptamine 3 receptor antagonist, in rabbit nodose ganglion and NIE-115 neuroblastoma cells. J Pharmacol Exp Ther. 1992;263:1127-1132.
-
(1992)
J Pharmacol Exp Ther
, vol.263
, pp. 1127-1132
-
-
Ito, H.1
Hidaka, K.2
Miyata, K.3
Kamato, T.4
Nishida, A.5
Honda, K.6
-
7
-
-
0036201379
-
Ramosetron, a 5-HT3 receptor antagonist for the control of nausea and vomiting
-
Rabasseda X. Ramosetron, a 5-HT3 receptor antagonist for the control of nausea and vomiting. Drugs Today. 2002;38:75-89.
-
(2002)
Drugs Today
, vol.38
, pp. 75-89
-
-
Rabasseda, X.1
-
8
-
-
0026319212
-
Serotonin (5-HT)3 receptor blocking activities of YMO60, a novel 4, 5, 6, 7-tetrahydrobenzimidazole derivative, and its enantiomer in anesthetized rats
-
Miyata K, Kamato T, Yamano M, et al. Serotonin (5-HT)3 receptor blocking activities of YMO60, a novel 4, 5, 6, 7-tetrahydrobenzimidazole derivative, and its enantiomer in anesthetized rats. J Pharmacol Exp Ther. 1991;259:815-819.
-
(1991)
J Pharmacol Exp Ther
, vol.259
, pp. 815-819
-
-
Miyata, K.1
Kamato, T.2
Yamano, M.3
-
10
-
-
2442476521
-
Role of serotonin in the pathophysiology of the irritable bowel syndrome
-
Crowell MD. Role of serotonin in the pathophysiology of the irritable bowel syndrome. Br J Pharmacol. 2004;141:1285-1293.
-
(2004)
Br J Pharmacol
, vol.141
, pp. 1285-1293
-
-
Crowell, M.D.1
-
11
-
-
34748863697
-
Effect of ramosetron on conditioned emotional stress-induced colonic dysfunction as a model of irritable bowel syndrome in rats
-
Funatsu T, Takeuchi A, Hirata T, Keto Y, Akuzawa S, Sasamata M. Effect of ramosetron on conditioned emotional stress-induced colonic dysfunction as a model of irritable bowel syndrome in rats. Eur J Pharmacol. 2007;573:190-195.
-
(2007)
Eur J Pharmacol
, vol.573
, pp. 190-195
-
-
Funatsu, T.1
Takeuchi, A.2
Hirata, T.3
Keto, Y.4
Akuzawa, S.5
Sasamata, M.6
-
12
-
-
33847365318
-
Pharmacological profile of ramosetron, a novel therapeutic agent for IBS
-
Hirata T, Funatsu T, Keto Y, Nakata M, Sasamata M. Pharmacological profile of ramosetron, a novel therapeutic agent for IBS. Inflammopharmacology. 2007;15:5-9.
-
(2007)
Inflammopharmacology
, vol.15
, pp. 5-9
-
-
Hirata, T.1
Funatsu, T.2
Keto, Y.3
Nakata, M.4
Sasamata, M.5
-
13
-
-
0036024228
-
The effect of the 5-HT3 receptor antagonist, alosetron, on brain responses to visceral stimulation in irritable bowel syndrome patients
-
Mayer EA, Berman S, Derbyshire SW, et al. The effect of the 5-HT3 receptor antagonist, alosetron, on brain responses to visceral stimulation in irritable bowel syndrome patients. Aliment Pharmacol Ther. 2002;16:1357-1366.
-
(2002)
Aliment Pharmacol Ther
, vol.16
, pp. 1357-1366
-
-
Mayer, E.A.1
Berman, S.2
Derbyshire, S.W.3
-
14
-
-
0027340594
-
A 5-HT3 receptor agonist induces neutrally mediated chloride transport in rat distal colon
-
Siriwardena AK, Budhoo MR, Smith EP, Kellum JM. A 5-HT3 receptor agonist induces neutrally mediated chloride transport in rat distal colon. J Surg Res. 1993;55:55-59.
-
(1993)
J Surg Res
, vol.55
, pp. 55-59
-
-
Siriwardena, A.K.1
Budhoo, M.R.2
Smith, E.P.3
Kellum, J.M.4
-
15
-
-
0038786708
-
The enteric nervous system III: A target for pharmacological treatment
-
Hansen MB. The enteric nervous system III: a target for pharmacological treatment. Pharmacol Toxicol. 2003;93:1-13.
-
(2003)
Pharmacol Toxicol
, vol.93
, pp. 1-13
-
-
Hansen, M.B.1
-
16
-
-
0026612742
-
Role of the serotonin3 receptor in stress-induced defecation
-
Miyata K, Kamato T, Nishida A, et al. Role of the serotonin3 receptor in stress-induced defecation. J Pharmacol Exp Ther. 1992;261: 297-303.
-
(1992)
J Pharmacol Exp Ther
, vol.261
, pp. 297-303
-
-
Miyata, K.1
Kamato, T.2
Nishida, A.3
-
17
-
-
0034066325
-
The 5-HT(3) receptor antagonist alosetron inhibits the colorectal distention induced depressor response and spinal c-fos expression in the anaesthetized rat
-
Kozlowski CM, Green A, Grundy D, Boissonade FM, Bountra C. The 5-HT(3) receptor antagonist alosetron inhibits the colorectal distention induced depressor response and spinal c-fos expression in the anaesthetized rat. Gut. 2000;46:474-480.
-
(2000)
Gut
, vol.46
, pp. 474-480
-
-
Kozlowski, C.M.1
Green, A.2
Grundy, D.3
Boissonade, F.M.4
Bountra, C.5
-
18
-
-
18744388283
-
Systematic review on the management of irritable bowel syndrome in North America
-
Brandt LJ, Bjorkman D, Fennerty MB, et al. Systematic review on the management of irritable bowel syndrome in North America. Am J Gastroenterol. 2002;97:S7-S26.
-
(2002)
Am J Gastroenterol
, vol.97
-
-
Brandt, L.J.1
Bjorkman, D.2
Fennerty, M.B.3
-
19
-
-
0034712539
-
Efficacy and safety of alosetron in women with irritable bowel syndrome: A randomised, placebo-controlled trial
-
Camilleri M, Northcutt AR, Kong S, Dukes GE, McSorley D, Mangel AW. Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial. Lancet. 2000;355:1035-1040.
-
(2000)
Lancet
, vol.355
, pp. 1035-1040
-
-
Camilleri, M.1
Northcutt, A.R.2
Kong, S.3
Dukes, G.E.4
McSorley, D.5
Mangel, A.W.6
-
20
-
-
0000036695
-
Cilansetron shows efficacy in male and female non-constipated patients with irritable bowel syndrome in a United States study
-
Caras S, Krause G, Biesheuvel E, Steinborn C. Cilansetron shows efficacy in male and female non-constipated patients with irritable bowel syndrome in a United States study. Gastroenterology. 2001;120:A217.
-
(2001)
Gastroenterology
, vol.120
-
-
Caras, S.1
Krause, G.2
Biesheuvel, E.3
Steinborn, C.4
-
21
-
-
0035994875
-
Contribution of P-glycoprotein to efflux of ramosetron, a 5-HT3 receptor antagonist, across the bloodbrain barrier
-
Yamamoto C, Murakami H, Koyabu N, et al. Contribution of P-glycoprotein to efflux of ramosetron, a 5-HT3 receptor antagonist, across the bloodbrain barrier. J Pharm Pharmacol. 2002;54: 1055-1063.
-
(2002)
J Pharm Pharmacol
, vol.54
, pp. 1055-1063
-
-
Yamamoto, C.1
Murakami, H.2
Koyabu, N.3
-
22
-
-
42249111897
-
Effects of serotonin 5-HT3 receptor antagonists on stress-induced colonic hyperalgesia and diarrhoea in rats: A comparative study with opioid receptor agonists, a muscarinic receptor antagonist and a synthetic polymer
-
Hirata T, Keto Y, Nakata M, et al. Effects of serotonin 5-HT3 receptor antagonists on stress-induced colonic hyperalgesia and diarrhoea in rats: a comparative study with opioid receptor agonists, a muscarinic receptor antagonist and a synthetic polymer. Neurogastroenterol Motil. 2008;20:557-565.
-
(2008)
Neurogastroenterol Motil
, vol.20
, pp. 557-565
-
-
Hirata, T.1
Keto, Y.2
Nakata, M.3
-
23
-
-
52149088774
-
A randomized, double-blind, placebo-controlled clinical trial of the effectiveness of the novel serotonin type 3 receptor antagonist ramosetron in both male and female Japanese patients with diarrhea-predominant irritable bowel syndrome
-
Matsueda K, Harasawa S, Hongo M, Hiwatashi N, Sasaki D. A randomized, double-blind, placebo-controlled clinical trial of the effectiveness of the novel serotonin type 3 receptor antagonist ramosetron in both male and female Japanese patients with diarrhea-predominant irritable bowel syndrome. Scand J Gastroenterol. 2008;43:1202-1211.
-
(2008)
Scand J Gastroenterol
, vol.43
, pp. 1202-1211
-
-
Matsueda, K.1
Harasawa, S.2
Hongo, M.3
Hiwatashi, N.4
Sasaki, D.5
-
24
-
-
0029847888
-
Novel 5-hydroxytryptamine (5-HT3) receptor antagonists. III. Pharmacological evaluations and molecular modeling studies of optically active 4,5,6,7-tetrahydro-1H-benzimidazole derivatives
-
Ohta M, Suzuki T, Furuya T, et al. Novel 5-hydroxytryptamine (5-HT3) receptor antagonists. III. Pharmacological evaluations and molecular modeling studies of optically active 4,5,6,7-tetrahydro-1H-benzimidazole derivatives. Chem Pharm Bull (Tokyo). 1996;44: 1707-1716.
-
(1996)
Chem Pharm Bull (Tokyo)
, vol.44
, pp. 1707-1716
-
-
Ohta, M.1
Suzuki, T.2
Furuya, T.3
-
25
-
-
0031593914
-
Comparative study of [3H] ramosetron and [3H] granisetron binding in the cloned human 5-hydroxytryptamine 3 receptors
-
Akuzawa S, lto H, Yamaguchi T. Comparative study of [3H] ramosetron and [3H] granisetron binding in the cloned human 5-hydroxytryptamine 3 receptors. Jpn J Pharmacol. 1998;78:381-384.
-
(1998)
Jpn J Pharmacol
, vol.78
, pp. 381-384
-
-
Akuzawa, S.1
Lto, H.2
Yamaguchi, T.3
-
26
-
-
0028170470
-
Serotonin (5-HT)3 receptor antagonism of 4,5,6,7-tetra-hydrobenzimidazole derivatives against 5-HT-induced bradycardia in anesthetized rats
-
Yamano M, Kamato T, Nishida A, et al. Serotonin (5-HT)3 receptor antagonism of 4,5,6,7-tetra-hydrobenzimidazole derivatives against 5-HT-induced bradycardia in anesthetized rats. Jpn J Pharmacol. 1994;65:241-248.
-
(1994)
Jpn J Pharmacol
, vol.65
, pp. 241-248
-
-
Yamano, M.1
Kamato, T.2
Nishida, A.3
-
27
-
-
0036968217
-
Serotoninergic modulating drugs for functional gastrointestinal diseases
-
Spiller R. Serotoninergic modulating drugs for functional gastrointestinal diseases. Br J Clin Pharmacol. 2002;54:11-20.
-
(2002)
Br J Clin Pharmacol
, vol.54
, pp. 11-20
-
-
Spiller, R.1
-
28
-
-
0023747271
-
Conditional analgesia, defensive freezing, and benzodiazepines
-
Fanselow MS, Helmstetter FJ. Conditional analgesia, defensive freezing, and benzodiazepines. Behav Neurosci. 1988;102:233-243.
-
(1988)
Behav Neurosci
, vol.102
, pp. 233-243
-
-
Fanselow, M.S.1
Helmstetter, F.J.2
-
29
-
-
0021912505
-
Effects of antidepressant drugs on a quickly-learned conditioned-suppression response in mice
-
Kameyama T, Nagasaka M, Yamada K. Effects of antidepressant drugs on a quickly-learned conditioned-suppression response in mice. Neuropharmacology. 1985;24:285-290.
-
(1985)
Neuropharmacology
, vol.24
, pp. 285-290
-
-
Kameyama, T.1
Nagasaka, M.2
Yamada, K.3
-
30
-
-
48049093262
-
A phase II trial of the novel serotonin type 3 receptor antagonist ramosetron in Japanese male and female patients with diarrhea-predominant irritable bowel syndrome
-
Matsueda K, Harasawa S, Hongo M, Hiwatashi N, Sasaki D. A phase II trial of the novel serotonin type 3 receptor antagonist ramosetron in Japanese male and female patients with diarrhea-predominant irritable bowel syndrome. Digestion. 2008;77:225-235.
-
(2008)
Digestion
, vol.77
, pp. 225-235
-
-
Matsueda, K.1
Harasawa, S.2
Hongo, M.3
Hiwatashi, N.4
Sasaki, D.5
-
31
-
-
13744263696
-
A dose-ranging, phase II study of the efficacy and safety of alosetron in men with diarrhea-predominant IBS
-
Chang L, Ameen VZ, Dukes GE, McSorley DJ, Carter EG, Mayer EA. A dose-ranging, phase II study of the efficacy and safety of alosetron in men with diarrhea-predominant IBS. Am J Gastroenterol. 2005;100: 115-123.
-
(2005)
Am J Gastroenterol
, vol.100
, pp. 115-123
-
-
Chang, L.1
Ameen, V.Z.2
Dukes, G.E.3
McSorley, D.J.4
Carter, E.G.5
Mayer, E.A.6
-
32
-
-
81855185606
-
Efficacy of ramosetron in the treatment of male patients with irritable bowel syndrome with diarrhea: A multicenter, randomized clinical trial, compared with mebeverine
-
Lee KJ, Kim NY, Kwon JK, et al. Efficacy of ramosetron in the treatment of male patients with irritable bowel syndrome with diarrhea: a multicenter, randomized clinical trial, compared with mebeverine. Neurogastroenterol Motil. 2011;23:1098-1104.
-
(2011)
Neurogastroenterol Motil
, vol.23
, pp. 1098-1104
-
-
Lee, K.J.1
Kim, N.Y.2
Kwon, J.K.3
-
33
-
-
84880814199
-
Long-term study of YM060 (ramosetron hydrochloride) in Japanese patients (male) with diarrhea-predominant irritable bowel syndrome
-
Japanese with English abstract
-
Matsueda K, Arakawa T, Matsumoto T, Sasaki D. Long-term study of YM060 (ramosetron hydrochloride) in Japanese patients (male) with diarrhea-predominant irritable bowel syndrome. Rinsho Iyaku. 2008;24:655-678. Japanese with English abstract.
-
(2008)
Rinsho Iyaku
, vol.24
, pp. 655-678
-
-
Matsueda, K.1
Arakawa, T.2
Matsumoto, T.3
Sasaki, D.4
-
34
-
-
0038724271
-
Sex-related differences in IBS patients: Central processing of visceral stimuli
-
Naliboff BD, Berman S, Chang L, et al. Sex-related differences in IBS patients: central processing of visceral stimuli. Gastroenterology. 2003;124:1738-1747.
-
(2003)
Gastroenterology
, vol.124
, pp. 1738-1747
-
-
Naliboff, B.D.1
Berman, S.2
Chang, L.3
-
35
-
-
0034210451
-
Gender differences in regional brain response to visceral pressure in IBS patients
-
Berman S, Munakata J, Naliboff BD, et al. Gender differences in regional brain response to visceral pressure in IBS patients. Eur J Pain. 2000;4:157-172.
-
(2000)
Eur J Pain
, vol.4
, pp. 157-172
-
-
Berman, S.1
Munakata, J.2
Naliboff, B.D.3
-
36
-
-
4644293513
-
Association between a functional polymorphism in the serotonin transporter gene and diarrhea predominant irritable bowel syndrome in women
-
Yeo A, Boyd P, Lumsden S, et al. Association between a functional polymorphism in the serotonin transporter gene and diarrhea predominant irritable bowel syndrome in women. Gut. 2004;53: 1452-1458.
-
(2004)
Gut
, vol.53
, pp. 1452-1458
-
-
Yeo, A.1
Boyd, P.2
Lumsden, S.3
-
37
-
-
4644285181
-
Is there a SERT-ain association with IBS?
-
Camilleri M. Is there a SERT-ain association with IBS? Gut. 2004;53: 1396-1399.
-
(2004)
Gut
, vol.53
, pp. 1396-1399
-
-
Camilleri, M.1
-
38
-
-
0032848856
-
Improvement in pain and bowel function in female irritable bowel patients with alosetron, a 5-HT3 receptor antagonist
-
Camilleri M, Mayer EA, Drossman DA, et al. Improvement in pain and bowel function in female irritable bowel patients with alosetron, a 5-HT3 receptor antagonist. Aliment Pharmacol Ther. 1999;13:1149-1159.
-
(1999)
Aliment Pharmacol Ther
, vol.13
, pp. 1149-1159
-
-
Camilleri, M.1
Mayer, E.A.2
Drossman, D.A.3
-
39
-
-
42749097353
-
Effects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptom relief and constipation in nonconstipated irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials
-
Andresen V, Montori VM, Keller J, West CP, Layer P, Camilleri M. Effects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptom relief and constipation in nonconstipated irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials. Clin Gastroenterol Hepatol. 2008;6:545-555.
-
(2008)
Clin Gastroenterol Hepatol
, vol.6
, pp. 545-555
-
-
Andresen, V.1
Montori, V.M.2
Keller, J.3
West, C.P.4
Layer, P.5
Camilleri, M.6
-
40
-
-
33847066213
-
Patients with irritable bowel syndrome or constipation have an increased risk for ischaemic colitis
-
Suh DC, Kahler KH, Choi IS, Shin H, Kralstein J, Shetzline M. Patients with irritable bowel syndrome or constipation have an increased risk for ischaemic colitis. Aliment Pharmacol Ther. 2007;25:681-692.
-
(2007)
Aliment Pharmacol Ther
, vol.25
, pp. 681-692
-
-
Suh, D.C.1
Kahler, K.H.2
Choi, I.S.3
Shin, H.4
Kralstein, J.5
Shetzline, M.6
-
41
-
-
79953727524
-
Targeting the 5-HT3 receptor in the treatment of irritable bowel syndrome
-
Spiller RC. Targeting the 5-HT3 receptor in the treatment of irritable bowel syndrome. Curr Opin Pharmacol. 2011;11:68-74
-
(2011)
Curr Opin Pharmacol
, vol.11
, pp. 68-74
-
-
Spiller, R.C.1
|