Erythrocytes encapsulated with phenylalanine hydroxylase exhibit improved pharmacokinetics and lowered plasma phenylalanine levels in normal mice

Molecular Genetics and Metabolism

Volumn 109, Issue 4, 2013, Pages 339-344

  Yew, Nelson S ^a   Dufour, Emmanuelle ^b   Przybylska, Malgorzata ^a   Putelat, Julie ^b   Crawley, Cristin ^a   Foster, Meta ^a   Gentry, Sarah ^a   Reczek, David ^a   Kloss, Alla ^a   Meyzaud, Aurélien ^b   Horand, Françoise ^b   Cheng, Seng H ^a   Godfrin, Yann ^b  

^a SANOFI   (France)

^b ERYTECH PHARMA   (France)

Author keywords

Drug delivery; Enzyme therapy; Erythrocytes; Pharmacokinetics; Phenylalanine; Phenylketonuria

Indexed keywords

HEMOGLOBIN; PHENYLALANINE; PHENYLALANINE 4 MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ENCAPSULATION; CIRCULATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REPLACEMENT; ERYTHROCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN METABOLISM; ANIMAL; BLOOD; DRUG DELIVERY SYSTEM; ENZYMOLOGY; GENETICS; HUMAN; LIVER; METABOLISM; PHENYLKETONURIAS;

MURINAE; MUS;

ANIMALS; DRUG DELIVERY SYSTEMS; ENZYME REPLACEMENT THERAPY; ERYTHROCYTES; HEMOGLOBINS; HUMANS; LIVER; MICE; PHENYLALANINE; PHENYLALANINE HYDROXYLASE; PHENYLKETONURIAS;

EID: 84880793764     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2013.05.011     Document Type: Article

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