Improved pharmacodynamics of L-asparaginase-loaded in human red blood cells

European Journal of Clinical Pharmacology

Volumn 49, Issue 6, 1996, Pages 465-470

  Kravtzoff, R ^a   Desbois, I ^b   Lamagnere, J P ^c   Muh, J P ^c   Valat, Ch ^c   Chassaigne, M ^b   Colombat, Ph ^c   Ropars, C ^a  

^a INSERM   (France)

^b Centre Régional de Transfusion Sanguine   (France)

^c UNIVERSITY HOSPITAL OF TOURS   (France)

Author keywords

Erythrocytes; L Asparaginase; carrier; Lysed resealed erythrocytes; Pharmacodynamics

Indexed keywords

ASPARAGINASE; DRUG CARRIER;

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; ERYTHROCYTE; HUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; ANTINEOPLASTIC AGENTS; ASPARAGINASE; DIALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; ERYTHROCYTE INDICES; ERYTHROCYTES; HALF-LIFE; HUMANS; ISOTOPE LABELING; MIDDLE AGED; OSMOLAR CONCENTRATION; OSMOTIC FRAGILITY;

EID: 0029995124     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00195932     Document Type: Article

References (21)

1. Alpar OH, Lewis DA (1985) Therapeutic efficacy of asparaginase encapsulated in intact erythrocytes. Biochem Pharmacol 34:257-261
2. Asselin BL, Whitin JC, Coppola DJ, Rupp IP, Sallan SE, Cohen HJ (1993) Comparative pharmacokinetic studies of three asparaginase preparations. J Clin Oncol 11:1780-1786
3. Ataullakhanov FI, Vitviskii VM, Zhabotinskii AM, Pichugin AV (1985) Permeability of human erythrocytes to asparagine. Biochemistry (translation of Biokhimiya) 50:1480-1484
4. Bendich A, Kafkewitz D, Abuchowski A, Davis FF (1982) Immunological effects of native and polyethyleneglycol modified asparaginase from Vibrio succinogenes and Escherichia coli in normal and tumor-bearing mice. Clin Exp Immunol 48:273-278
5. Cheung N, Chau IY, Coccia PF (1986) Antibody response to Escherichia coli L-asparaginase. Prognostic significance and clinical utility of antibody measurement. Am J Ped Hematol Oncol 8:99-104
6. Cooney DA, Capizzi RL, Handschumacher RE (1970) Evaluation of asparagine metabolism in animals and man. Cancer Res 30:929-935
7. Evans WE, Tiatis A, Rivera G, Murphy SB, Dahl GV, Denison M, Crom W R, Barker L F, Mauer A M (1982) Anaphylactoid reactions to E. coll and Erwinia asparaginase in children with leukemia or lymphoma. Cancer 49:1378-1383
8. Fabry U, Körholz D, Jyürgens H, Göbel U, Wahn V (1985) Anaphylaxis to L-asparaginase during treatment for acute lymphoblastic leukemia in children - evidence of a complement-mediated mechanism. Fed Res 19:400-408
9. Fauconnet M, Richomont J (1978) A single column amino acid analysis method which resolves hexosamines and several cysteine derivatives. Anal Biochem 91:400-408
10. Garin MI, Kravtzoff R, Chestier N, Pinilla M, Luque J, Ropars C (1994) Separation on a density gradient of human L-asparaginase loaded RBC. Biochem Mol Biol Int 33:807-814
11. Kravtzoff R, Ropars C, Laguerre M, Muh J P, Chassaigne M (1990) Erythrocytes as carriers for L-asparaginase. Methodological and mouse in-vivo studies. J Pharm Pharmacol 42:473-476
12. Kravtzoff R, Desbois I, Chassaigne M, Muh JP, Lamagnere JP, Colombat Ph, Ropars C (1991) In vivo activity of L-asparaginase entrapped into human and mouse red blood cells. Adv Biosci 81:127-139
13. Muss HB, Spell N, Scudiery D, Capizzi RL, Cooper MR, Cruz J, Jackson DV, Richards F, Spurr CL, White DR, Zekan PJ, Franklin A (1990) A phase II trial of peg-L-asparaginase in the treatment of non-Hodgkin's lymphoma. Invest New Drugs 8:125-130
14. Nesbit ME, Ertel I, Hamond GD (1981) L-asparaginase as a single agent in acute lymphocytic leukemia: survey of studies from children's cancer group. Cancer Treat Rep 65:101-107
15. Oettgen HF, Old LJ, Boyse EA, Campbell HA, Phillips FS, Clarkon BD, Tallal L, Leeper RD, Schwartz MK, Kim LH (1967) Inhibition of leukemias in man by L-asparaginase. Cancer Res 27:2619-2631
16. Oettgen HF, Stephenson PA, Schwartz MK, Leeper RD, Tallal L, Tan C, Clarkson BD, Golbey RB, Krakoff IK, Karnovsky DA, Murphy ML, Burchenal JH (1970) Toxicity of E coli L-asparaginase in man. Cancer 25:253-277
17. Ohnuma T, Holland J, Freemen A, Sinks L (1970) Biochemical and pharmacological studies with asparaginase in man. Cancer Res 30:2297-2305
18. Peterson RG, Handschumacher RE, Mitchell MS (1971) Immunological response to L-asparaginase. J Clin Invest 50: 1080-1090
19. Ropars C, Chassaigne M, Villereal MC, Avenard G, Hurel C, Nicolau C (1985) Resealed RBC as a new blood transfusion product. Bibl Haematol 51:82-91
20. Updike SJ, Wakamiya RT (1983) Infusion of red blood cell-loaded asparaginase in monkeys: immunologic metabolic and toxico-logic consequences. J Lab Clin Med 101:679-690
21. Updike SJ (1985) Entrapment of L-asparaginase in red blood cells. Bibl Haematol 51:65-74