Fibronectin contributes to pathological cardiac hypertrophy but not physiological growth

Basic Research in Cardiology

Volumn 108, Issue 5, 2013, Pages

  Konstandin, Mathias H ^a   Völkers, Mirko ^a   Collins, Brett ^a   Quijada, Pearl ^a   Quintana, Mercedes ^a   De La Torre, Andrea ^a   Ormachea, Lucy ^a   Din, Shabana ^a   Gude, Natalie ^a   Toko, Haruhiro ^a   Sussman, Mark A ^a  

^a SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

Cardiomyocytes; Fibronectin; Heart failure; Pathological and physiological hypertrophy

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; FIBRONECTIN; TRANSCRIPTION FACTOR NFAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SWELLING; CONTROLLED STUDY; GENE ACTIVATION; HEART DEVELOPMENT; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; IN VITRO STUDY; MALE; MOLECULAR PATHOLOGY; MOUSE; NEWBORN; NONHUMAN; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN TRANSPORT; RAT;

EID: 84880789536     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-013-0375-8     Document Type: Article

References (43)

1. Arslan F, Smeets MB, Riem Vis PW, Karper JC, Quax PH, Bongartz LG, Peters JH, Hoefer IE, Doevendans PA, Pasterkamp G, de Kleijn DP (2011) Lack of fibronectin-EDA promotes survival and prevents adverse remodeling and heart function deterioration after myocardial infarction. Circ Res 108:582-592. doi: 10.1161/CIRCRESAHA.110.224428
2. Battiprolu PK, Hojayev B, Jiang N, Wang ZV, Luo X, Iglewski M, Shelton JM, Gerard RD, Rothermel BA, Gillette TG, Lavandero S, Hill JA (2012) Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice. J Clin Invest 122:1109-1118. doi: 10.1172/JCI60329
3. Booth AJ, Wood SC, Cornett AM, Dreffs AA, Lu G, Muro AF, White ES, Bishop DK (2012) Recipient-derived EDA fibronectin promotes cardiac allograft fibrosis. J Pathol 226:609-618. doi: 10.1002/path.3010
4. Bostrom P, Mann N, Wu J, Quintero PA, Plovie ER, Panakova D, Gupta RK, Xiao C, MacRae CA, Rosenzweig A, Spiegelman BM (2010) C/EBPbeta controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell 143:1072-1083. doi: 10.1016/j.cell.2010.11.036
5. Carraway MS, Suliman HB, Jones WS, Chen CW, Babiker A, Piantadosi CA (2010) Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart. Circ Res 106:1722-1730. doi: 10.1161/CIRCRESAHA.109.214353
6. Chen H, Huang XN, Yan W, Chen K, Guo L, Tummalapali L, Dedhar S, St-Arnaud R, Wu C, Sepulveda JL (2005) Role of the integrin-linked kinase/PINCH1/alpha-parvin complex in cardiac myocyte hypertrophy. Lab Invest 85:1342-1356. doi: 10.1038/labinvest.3700345 (Pubitemid 41509383)
7. Crawford DC, Chobanian AV, Brecher P (1994) Angiotensin II induces fibronectin expression associated with cardiac fibrosis in the rat. Circ Res 74:727-739. doi: 10.1161/01RES.74.4.727 (Pubitemid 24088533)
8. Dobaczewski M, Gonzalez-Quesada C, Frangogiannis NG (2010) The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction. J Mol Cell Cardiol 48:504-511. doi: 10.1016/j.yjmcc.2009.07.015
9. Finsen AV, Lunde IG, Sjaastad I, Ostli EK, Lyngra M, Jarstadmarken HO, Hasic A, Nygard S, Wilcox-Adelman SA, Goetinck PF, Lyberg T, Skrbic B, Florholmen G, Tonnessen T, Louch WE, Djurovic S, Carlson CR, Christensen G (2011) Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway. PLoS One 6:e28302. doi: 10.1371/journal.pone.0028302
10. Frangogiannis NG (2011) Matricellular proteins in cardiac adaptation and disease. Phys Rev 92:635-688. doi: 10.1152/physrev.00008.2011
11. Frey N, Katus HA, Olson EN, Hill JA (2004) Hypertrophy of the heart: a new therapeutic target? Circulation 109:1580-1589. doi: 10.1161/01.CIR. 0000120390.68287.BB (Pubitemid 38451712)
12. Frey N, Olson EN (2003) Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol 65:45-79. doi: 10.1146/annurev.physiol.65.092101.142243 (Pubitemid 38249147)
13. Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong TT, Shaw RM, Srivastava D (2009) Cardiac fibroblasts regulate myocardial proliferation through β1 integrin signaling. Dev Cell 16:233-244. doi: 10.1016/j.devcel.2008.12.007
14. Knowlton AA, Connelly CM, Romo GM, Mamuya W, Apstein CS, Brecher P (1992) Rapid expression of fibronectin in the rabbit heart after myocardial infarction with and without reperfusion. J Clin Invest 89:1060-1068. doi: 10.1172/JCI115685
15. Koitabashi N, Bedja D, Zaiman AL, Pinto YM, Zhang M, Gabrielson KL, Takimoto E, Kass DA (2009) Avoidance of transient cardiomyopathy in cardiomyocyte-targeted tamoxifen-induced MerCreMer gene deletion models. Circ Res 105:12-15. doi: 10.1161/CIRCRESAHA.109.198416
16. Konstandin MH, Toko H, Gastelum GM, Quijada PJ, De La Torre A, Quintana M, Collins B, Din S, Avitabile D, Volkers MJ, Gude NA, Fassler R, Sussman MA (2013) Fibronectin is essential for reparative cardiac progenitor cell response following myocardial infarction. Circ Res 113:115-125. doi: 10.1161/CIRCRESAHA. 113.301152
17. Leipner C, Grun K, Muller A, Buchdunger E, Borsi L, Kosmehl H, Berndt A, Janik T, Uecker A, Kiehntopf M, Bohmer FD (2008) Imatinib mesylate attenuates fibrosis in coxsackievirus b3-induced chronic myocarditis. Cardiovasc Res 79:118-126. doi: 10.1093/cvr/cvn063 (Pubitemid 351881931)
18. Leiss M, Beckmann K, Giros A, Costell M, Fassler R (2008) The role of integrin binding sites in fibronectin matrix assembly in vivo. Curr Opin Cell Biol 20:502-507. doi: 10.1016/j.ceb.2008.06.001
19. Li L, Muhlfeld C, Niemann B, Pan R, Li R, Hilfiker-Kleiner D, Chen Y, Rohrbach S (2011) Mitochondrial biogenesis and PGC-1 alpha deacetylation by chronic treadmill exercise: differential response in cardiac and skeletal muscle. Bas Res Cardiol 106:1221-1234. doi: 10.1007/s00395-011-0213-9
20. Lu J, Bian ZY, Zhang R, Zhang Y, Liu C, Yan L, Zhang SM, Jiang DS, Wei X, Zhu XH, Chen M, Wang AB, Chen Y, Yang Q, Liu PP, Li H (2013) Interferon regulatory factor 3 is a negative regulator of pathological cardiac hypertrophy. Bas Res Cardiol 108:326. doi: 10.1007/s00395-012-0326-9
21. MacDonnell SM, Weisser-Thomas J, Kubo H, Hanscome M, Liu Q, Jaleel N, Berretta R, Chen X, Brown JH, Sabri AK, Molkentin JD, Houser SR (2009) CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes. Circ Res 105:316-325. doi: 10.1161/CIRCRESAHA.109.194035
22. Maillet M, van Berlo JH, Molkentin JD (2013) Molecular basis of physiological heart growth: fundamental concepts and new players. Nat Rev Mol Cell Biol 14:38-48. doi: 10.1038/nrm3495
23. McMullen JR, Amirahmadi F, Woodcock EA, Schinke-Braun M, Bouwman RD, Hewitt KA, Mollica JP, Zhang L, Zhang Y, Shioi T, Buerger A, Izumo S, Jay PY, Jennings GL (2007) Protective effects of exercise and phosphoinositide 3-kinase (p110alpha) signaling in dilated and hypertrophic cardiomyopathy. Proc Natl Acad Sci USA 104:612-617. doi: 10.1073/pnas.0606663104 (Pubitemid 46123073)
24. Munoz R, Moreno M, Oliva C, Orbenes C, Larrain J (2006) Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos. Nat Cell Biol 8:492-500. doi: 10.1038/ncb1399
25. Muraski JA, Rota M, Misao Y, Fransioli J, Cottage C, Gude N, Esposito G, Delucchi F, Arcarese M, Alvarez R, Siddiqi S, Emmanuel GN, Wu W, Fischer K, Martindale JJ, Glembotski CC, Leri A, Kajstura J, Magnuson N, Berns A, Beretta RM, Houser SR, Schaefer EM, Anversa P, Sussman MA (2007) Pim-1 regulates cardiomyocyte survival downstream of Akt. Nat Med 13:1467-1475. doi: 10.1038/nm1671 (Pubitemid 350224243)
26. Nadu AP, Ferreira AJ, Reudelhuber TL, Bader M, Santos RA (2008) Reduced isoproterenol-induced renin-angiotensin changes and extracellular matrix deposition in hearts of TGR (A1-7)3292 rats. J Am Soc Hypertens 2:341-348. doi: 10.1016/j.jash.2008.04.012
27. Ogawa E, Saito Y, Harada M, Kamitani S, Kuwahara K, Miyamoto Y, Ishikawa M, Hamanaka I, Kajiyama N, Takahashi N, Nakagawa O, Masuda I, Kishimoto I, Nakao K (2000) Outside-in signalling of fibronectin stimulates cardiomyocyte hypertrophy in cultured neonatal rat ventricular myocytes. J Mol Cell Cardiol 32:765-776. doi: 10.1006/jmcc.2000.1119 (Pubitemid 30658914)
28. Oh M, Dey A, Gerard RD, Hill JA, Rothermel BA (2010) The CCAAT/enhancer binding protein beta (C/EBPbeta) cooperates with NFAT to control expression of the calcineurin regulatory protein RCAN1-4. J Biol Chem 285:16623-16631. doi: 10.1074/jbc.M109.098236
29. Oliver N, Babu M, Diegelmann R (1992) Fibronectin gene transcription is enhanced in abnormal wound healing. J Inv Dermatol 99:579-586. doi: 10.1111/1523-1747.ep12667776
30. Piepoli MF, Conraads V, Corra U, Dickstein K, Francis DP, Jaarsma T, McMurray J, Pieske B, Piotrowicz E, Schmid JP, Anker SD, Solal AC, Filippatos GS, Hoes AW, Gielen S, Giannuzzi P, Ponikowski PP (2011) Exercise training in heart failure: from theory to practice. A consensus document of the heart failure association and the European association for cardiovascular prevention and rehabilitation. Eur J Heart Fail 13:347-357. doi: 10.1093/eurjhf/hfr017
31. Plante E, Lachance D, Gaudreau M, Drolet MC, Roussel E, Arsenault M, Couet J (2004) Effectiveness of beta-blockade in experimental chronic aortic regurgitation. Circulation 110:1477-1483. doi: 10.1161/01.CIR.0000141733.55236. 9D (Pubitemid 39238027)
32. Reilly JT, McVerry BA, Mackie MJ (1983) Fibronectin in blood products-an in vitro and in vivo study. J Clin Pathol 36:1377-1381. doi: 10.1136/jcp.36.12.1377 (Pubitemid 14204722)
33. Rohwedder I, Montanez E, Beckmann K, Bengtsson E, Duner P, Nilsson J, Soehnlein O, Fassler R (2012) Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation. EMBO Mol Med 4:564-576. doi: 10.1002/emmm.201200237
34. Roof SR, Tang L, Ostler JE, Periasamy M, Gyorke S, Billman GE, Ziolo MT (2013) Neuronal nitric oxide synthase is indispensable for the cardiac adaptive effects of exercise. Bas Res Cardiol 108:332. doi: 10.1007/s00395-013-0332-6
35. Sakai T, Johnson KJ, Murozono M, Sakai K, Magnuson MA, Wieloch T, Cronberg T, Isshiki A, Erickson HP, Fassler R (2001) Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis. Nat Med 7:324-330. doi: 10.1038/85471 (Pubitemid 32224348)
36. Samuel JL, Barrieux A, Dufour S, Dubus I, Contard F, Koteliansky V, Farhadian F, Marotte F, Thiery JP, Rappaport L (1991) Accumulation of fetal fibronectin mRNAs during the development of rat cardiac hypertrophy induced by pressure overload. J Clin Invest 88:1737-1746. doi: 10.1172/JCI115492
37. Sharma S, Quintana A, Findlay GM, Mettlen M, Baust B, Jain M, Nilsson R, Rao A, Hogan PG (2013) An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca entry. Nature 499:238-242. doi: 10.1038/nature12229
38. Spinale FG (2007) Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. Phys Rev 87:1285-1342. doi: 10.1152/physrev.00012.2007 (Pubitemid 350041472)
39. Taylor JM, Rovin JD, Parsons JT (2000) A role for focal adhesion kinase in phenylephrine-induced hypertrophy of rat ventricular cardiomyocytes. J Biol Chem 275:19250-19257. doi: 10.1074/jbc.M909099199 (Pubitemid 30422897)
40. van Berlo JH, Maillet M, Molkentin JD (2013) Signaling effectors underlying pathologic growth and remodeling of the heart. J Clin Invest 123:37-45. doi: 10.1172/JCI62839
41. van Rooij E, Doevendans PA, de Theije CC, Babiker FA, Molkentin JD, de Windt LJ (2002) Requirement of nuclear factor of activated T-cells in calcineurin-mediated cardiomyocyte hypertrophy. J Biol Chem 277:48617-48626. doi: 10.1074/jbc.M206532200 (Pubitemid 35470824)
42. Villarreal FJ, Kim NN, Ungab GD, Printz MP, Dillmann WH (1993) Identification of functional angiotensin II receptors on rat cardiac fibroblasts. Circulation 88:2849-2861. doi: 10.1161/01.CIR.88.6.2849 (Pubitemid 23360212)
43. Wilkins BJ, Dai YS, Bueno OF, Parsons SA, Xu J, Plank DM, Jones F, Kimball TR, Molkentin JD (2004) Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ Res 94:110-118. doi: 10.1161/01.RES.0000109415.17511.18 (Pubitemid 38064105)