Enzyme-induced vitreolysis can alleviate the progression of diabetic retinopathy through the HIF-1α pathway

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 7, 2013, Pages 4964-4970

  Wang, Zhiliang ^a   Li, Chuanyin ^a   Chen, Ping ^a   Zhang, Jingfa ^b   Zhang, Limei ^b   Huang, Xiaolin ^a   Yao, Yuting ^a   Che, Xin ^a   Fan, Xianqun ^a   Ge, Shengfang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Enzyme induced vitreolysis; HIF 1 ; Oxygen concentration; PEDF; Posterior vitreous detachment; VEGF

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; GLUCOSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PIGMENT EPITHELIUM DERIVED FACTOR; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CATARACT; CONTROLLED STUDY; DIABETIC RETINOPATHY; DISEASE COURSE; ENDOTHELIUM CELL; HISTOPATHOLOGY; MALE; NONHUMAN; OXYGEN CONCENTRATION; PERICYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RETINA EDEMA; SCANNING ELECTRON MICROSCOPY; SENSORY SYSTEM ELECTROPHYSIOLOGY; VITREOUS DISEASE; VITREOUS HEMORRHAGE; WESTERN BLOTTING;

ENZYME-INDUCED VITREOLYSIS; HIF-1Α; OXYGEN CONCENTRATION; PEDF; POSTERIOR VITREOUS DETACHMENT; VEGF;

ANIMALS; BLOTTING, WESTERN; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; DISEASE PROGRESSION; DRUG THERAPY, COMBINATION; FIBRINOLYSIN; FIBRINOLYTIC AGENTS; GENE EXPRESSION REGULATION; HYALURONOGLUCOSAMINIDASE; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTRAVITREAL INJECTIONS; MALE; MICROSCOPY, ELECTRON, SCANNING; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RNA; VITREOUS BODY;

EID: 84880771432     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-11443     Document Type: Article

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