The longitudinal pattern of response when morphine is used to treat chronic refractory dyspnea

Journal of Palliative Medicine

Volumn 16, Issue 8, 2013, Pages 881-886

  Currow, David C ^a   Quinn, Stephen ^a   Greene, Aine ^b   Bull, Janet ^c   Johnson, Miriam J ^d   Abernethy, Amy P ^a,e  

^a FLINDERS UNIVERSITY   (Australia)

^b REPATRIATION GENERAL HOSPITAL   (Australia)

^c Four Seasons Hospice   (United States)

^d UNIVERSITY OF HULL   (United Kingdom)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE; MORPHINE SULFATE;

ADULT; AGED; ARTICLE; CHRONIC DISEASE; CONTROLLED STUDY; DRUG DOSE TITRATION; DYSPNEA; FEMALE; HUMAN; KARNOFSKY PERFORMANCE STATUS; MAJOR CLINICAL STUDY; MALE; QUALITY OF LIFE; SECONDARY ANALYSIS; SUSTAINED DRUG RELEASE; VISUAL ANALOG SCALE;

ANALGESICS, OPIOID; AUSTRALIA; CHRONIC DISEASE; DELAYED-ACTION PREPARATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DYSPNEA; HUMANS; MORPHINE; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84880764685     PISSN: 10966218     EISSN: 15577740     Source Type: Journal    
DOI: 10.1089/jpm.2012.0591     Document Type: Article

References (36)

1. Abernethy AP, Currow DC, Frith P, Fazekas BS, McHugh A, Bui C: Randomised double-blind placebo-controlled crossover trial of sustained-release morphine for the management of refractory dyspnoea. Br Med J 2003;7414(327):523-525.
2. Currow DC, Plummer J, Crockett A, Abernethy AP: A community population survey of prevalence and severity of dyspnoea in adults. J Pain Symptom Manage 2009;38: 533-545.
3. Hammond E: Some preliminary findings on physical complaints from a prospective study of 1,064,004 men and women. Am J Pub Health 1964;54:11-23.
4. Currow DC, Smith J, Davidson PM, Newton PJ, Agar MR, Abernethy AP: Do the trajectories of dyspnoea differ in prevalence and intensity by diagnosis at the end of life? A consecutive cohort study. J Pain Symptom Manage 2010; 39:680-690.
5. Seow H, Barbera L, Sutradhar R, Howell D, Dudgeon D, Atzema C, Liu Y, Husain A, Sussman J, Earle C: Trajectory of performance status and symptom scores for patients with cancer during the last six months of life. J Clin Oncol 2011; 29:1151-1158.
6. Jennings AL, Davies AN, Higgins JP, Gibbs JR, Broadley KE: A systematic review of the use of opioids in the management of dyspnea. Thorax 2002;57:939-944.
7. Currow DC, McDonald C, Oaten S, Kenny B, Allcroft P, Frith P, Briffa M, Johnson MJ, Abernethy AP: Once-daily opioids for chronic dyspnoea: A dose increment and pharmacovigilance study. J Pain Symptom Manage 2011;42: 388-399.
8. Johnson MJ, Bland MJ, Oxberry SG, Abernethy AP, Currow DC: Opioids for chronic refractory breathlessness: Patient predictors of beneficial response. Eur Respir J 2012. (Epub ahead of print, Dec. 20, 2012)
9. Mahler DA, Murray JA, Waterman LA, et al.: Endogenous opioids modify dyspnoea during treadmill exercise in patients with COPD. Eur Respir J 2009;33:771-777.
10. Gifford AH, Mahler DA, Waterman LA, Ward J, Kraemer WJ, Kupchak BR, Baird JC: Neuromodulatory effect of endogenous opioids on the intensity and unpleasantness of breathlessness during resistive load breathing in COPD. COPD 2011;8:160-166.
11. Mahler DA, Selecky PA, Harrod CG, Benditt JO, Carrieri-Kohlman V, Curtis JR, Manning HLm Mularski RA, Varkey B, Campbell M, Carter ER, Chiong JR, Ely EW, Hansen-Flaschen J, O'Donnell DE, Waller A: American College of Chest Physicians consensus statement on the management of dyspnea in patients with advanced lung or heart disease. Chest 2010;137:674-691.
12. Parshall MB, Schwartzstein RM, Adams L, Banzett RB, Manning HL, Bourbeau J, Calverley PM, Gift AG, Harver A, Lareau SC, Mahler DA, Meek PM, O'Donnell DE; American Thoracic Society Committee on Dyspnea: An official American Thoracic Society statement: Update on the mechanisms, assessment, and management of dyspnea. Am J Respir Crit Care Med 2012;185:435-452.
13. Fletcher CM, Elmes PC, Fairbairn MB et al.: The significance of respiratory symptoms and the diagnosis of chronic bronchitis in a working population. Br Med J 1959;2:257-266.
14. Medical Research Council Committee on Aetiology of Chronic Bronchitis: Standardized questionnaires on respiratory symptoms. Br Med J 1960;II:1665.
15. Bestall JC, Paul EA, Garrod R, Garnham R, Jones PW, Wedzicha JA: Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease. Thorax 1999; 54:581-586.
16. Abernethy AP, Shelby-James TM, Fazekas BS, Woods D, Currow DC: The Australian-modified Karnofsky Performance Status (AKPS) scale: A revised scale for contemporary palliative care clinical practice. BMC Pall Care 2005;4:7.
17. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D: A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999;130:461-470.
18. Rossi S (ed): Australian Medicines Handbook. Adelaide: Australian Medicines Handbook, 2012.
19. Folstein MF, Folstein SE, McHugh PR: "Mini-mental state:" A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
20. Cohen SR, Mount BM, Strobel MG, Bui F: The McGill Quality of Life Questionnaire, a measure of quality of life appropriate for people with advanced disease: A preliminary study of validity and acceptability. Palliat Med 1995;9: 207-219.
21. Ries AL: Minimally clinically important difference for the UCSD Shortness of Breath Questionnaine, Borg Scale, and Visual Analogue Scale. COPD 2005;2:105-110.
22. Mahler DA: Mechanisms and measurement of dyspnea in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2006;3:234-238.
23. Oxberry SG, Bland JM, Clark AL, Cleland JGF, Johnson MJ: Minimally Clinically Important Difference (MCID) in chronic breathlessness: Every little helps. J Am Heart Assoc 2012;164:229-235.
24. Sloan JA: Assessing the minimally clinically significant difference: Scientific considerations, challenges and solutions. COPD 2005;2:57-62.
25. Wyrwich KW, Tierney WM, Wolinsky FD: Further evidence supporting an SEM-based criterion for identifying meaningful intra-individual changes in health-related quality of life. J Clin Epidemiol 1999;52:861-873.
26. Mahler DA, Witek TJ, Jr.: The MCID of the transition dyspnea index is a total score of one unit. COPD 2005;2:99-103.
27. Norman GR, Sloan JA, Wyrwich KW: Interpretation of changes in health-related quality of life: The remarkable universality of half a standard deviation. Med Care 2003; 41:582-592.
28. Johnson MJ, Bland JM, Oxberry SG, Abernethy AP, Currow DC: Clinically important differences in the intensity of chronic fractory breathlessness. J Pain Symptom Manage doi:ppi: S0885-3924(13)00186-3.10.1016/j.jpainsymman.2013. 01.011. [Epub a head of print 2013 Apr 19.]
29. Klepstad P, Kaasa S, Jystad A, et al.: Immediate-or sustained-release morphine for dose finding during start of morphine to cancer patients: A randomized, double-blind trial. Pain 2003;101(1):193-198.
30. Jensen D, Alsuhail A, Viola R, Dudgeon DJ, Webb KA, O'Donnell DE: Inhaled fentanyl citrate improves exercise endurance during high-intensity constant work rate cycle exercise in chronic obstructive pulmonary disease. J Pain Symptom Manage 2012;43:706-719.
31. Baker PS, Bodner EV, Allman RM: Measuring life-space mobility in community-dwelling older adults. J Am Geriatr Soc 2003;51:1610-1614.
32. Maddocks M, Wilcock A: Exploring physical activity level in patients with thoracic cancer: Implications for use as an outcome measure. Support Care Cancer 2012;20:1113-1116.
33. Currow DC, Abernethy AP, JohnsonMJ. Activity as a measure of symptom control. J Pain Symptom Manage 2012;44:e1-e2.
34. Currow DC, Abernethy AP, Johnson MJ: Activity as a measure of symptom control. J Pain Symptom Manage doi: 10.1016/j.jpainsymman.2012.07.005. [Epub ahead of print 2012 Sep 24]
35. Abernethy AP, McDonald CF, Frith PA, Clark K, Herndon JE, Marcello J, Young IH, Bull J, Wilcock A, Booth S, Wheeler JL, Tulsky JA, Crockett AJ, Currow DC: Effect of palliative oxygen versus room air in relieving breathlessness in patients with refractory dyspnea: A double-blind randomized controlled trial (NCT00327873). Lancet 2010;376: 784-793.
36. von Leupoldt A, Ambruzsova R, Nordmeyer S, Jeske N, Dahme B: Sensory and affective aspects of dyspnea contribute differentially to the Borg scale's measurement of dyspnea. Respiration 2006;73:762-768