Neuromodulatory effect of endogenous opioids on the intensity and unpleasantness of breathlessness during resistive load breathing in COPD

COPD: Journal of Chronic Obstructive Pulmonary Disease

Volumn 8, Issue 3, 2011, Pages 160-166

  Gifford, Alex H ^a   Mahler, Donald A ^a   Waterman, Laurie A ^b   Ward, Joseph ^b   Kraemer, William J ^c   Kupchak, Brian R ^c   Baird, John C ^a,d  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^c UNIVERSITY OF CONNECTICUT   (United States)

^d Psychological Applications   (United States)

Author keywords

Beta endorphins; Dyspnea; Naloxone; Resistive load breathing

Indexed keywords

BETA ENDORPHIN; CARBON DIOXIDE; NALOXONE; OPIATE; SODIUM CHLORIDE;

ADULT; AGED; ARTICLE; BREATHING; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DYSPNEA; EXPIRATORY FLOW; FEMALE; HEART RATE; HUMAN; HYPOTHESIS; IMMUNOREACTIVITY; INSPIRATORY CAPACITY; MALE; NEUROMODULATION; OXYGEN SATURATION; PHYSIOLOGY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESISTIVE LOAD BREATHING; TIDAL VOLUME; VISUAL ANALOG SCALE;

AGED; AIRWAY RESISTANCE; BETA-ENDORPHIN; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DYSPNEA; FEMALE; HUMANS; INSPIRATORY CAPACITY; MALE; MIDDLE AGED; NALOXONE; NARCOTIC ANTAGONISTS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RANDOM ALLOCATION; RESPIRATION;

EID: 79957601359     PISSN: 15412555     EISSN: 15412563     Source Type: Journal    
DOI: 10.3109/15412555.2011.560132     Document Type: Article

References (43)

1. Barbano MF, Cador M. Differential regulation of the consummatory, motivational and anticipatory aspects of feeding behavior by dopaminergic and opioidergic drugs. Neuropsychopharmacology 2006; 31:1371-1381.
2. Murphy MR, Checkley SA, Seckl JR, Lightman SL. Naloxone inhibits oxytocin release at orgasm inman. J Clin EndocrinolMetab 1990; 71:1056-1058.
3. Jarmukli NF, Ahn J, Iranmanesh A, Russell DC. Effect of raised plasma beta endorphin concentrations on peripheral pain and angina thresholds in patients with stable angina. Heart 1999; 82:204-209. (Pubitemid 29362872)
4. Santiago TV, Edelman NH. Opioids and breathing. J Appl Physiol 1985; 59:1675-1685.
5. Kirsch JL, Muro JR, Stansbury DW, Fischer CE, Monfore R, Light RW. Effect of naloxone on maximal exercise performance and control of ventilation in COPD. Chest 1989; 96:761-766. (Pubitemid 19256174)
6. Mahler DA, Murray JA, Waterman LA, Ward J, Kraemer WJ, Zhang X, Baird JC. Endogenous opioids modify dyspnoea during treadmill exercise in patients with COPD. Eur Respir J 2009; 33:771-777.
7. Carr DB, Bullen BA, Skrinar GS, Arnold MA, Rosenblatt M, Beitins IZ, Martin JB, McArthur JW. Physical conditioning facilitates the exercise-induced secretion of beta-endorphin and betalipotropin in women. N Engl J Med 1981; 305:560-563. (Pubitemid 12201134)
8. Gambert SR, Garthwaite TL, Pontzer CH, Cook EE, Tristani FE, Duthie EH,Martinson DR, Hagen TC,McCarty DJ. Running elevates plasma beta-endorphin immunoreactivity and ACTH in untrained human subjects. Proc Soc Exp Biol Med 1981; 168:1-4. (Pubitemid 12179207)
9. Thoren P, Floras JS, Hoffmann P, Seals DR. Endorphins and exercise: physiological mechanisms and clinical implications.Med Sci Sports Exerc 1990; 22:417-428. (Pubitemid 20241706)
10. Santiago TV, Remolina C, Scoles V, 3rd, Edelman NH. Endorphins and the control of breathing. Ability of naloxone to restore flow-resistive load compensation in chronic obstructive pulmonary disease. N Engl J Med 1981; 304:1190-1195. (Pubitemid 11102797)
11. Simon PM, Pope A, Lahive K, Steinbrook RA, Schwartzstein RM, Weiss JW, Fencl V, Weinberger SE. Naloxone does not alter response to hypercapnia or resistive loading in chronic obstructive pulmonary disease. Am Rev Respir Dis 1989; 139:134-138. (Pubitemid 19030434)
12. Vassilakopoulos T, Zakynthinos S, Roussos C. Strenuous resistive breathing induces proinflammatory cytokines and stimulates the HPA axis in humans. Am J Physiol 1999; 277:R1013-109.
13. Scardella AT, Parisi RA, Phair DK, Santiago TV, Edelman NH. The role of endogenous opioids in the ventilatory response to acute flow-resistive loads. Am Rev Respir Dis 1986; 133:26-31. (Pubitemid 16189091)
14. von Leupoldt A, Dahme B. Differentiation between the sensory and affective dimension of dyspnea during resistive load breathing in normal subjects. Chest 2005; 128:3345-3349. (Pubitemid 41698661)
15. Carrieri-Kohlman V, Donesky-Cuenco D, Park SK, Mackin L, Nguyen HQ, Paul SM. Additional evidence for the affective dimension of dyspnea in patients with COPD. Res Nurs Health 2010; 33:4-19.
16. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, van Weel C, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2007; 176:532-555. (Pubitemid 47403272)
17. Mahler DA, Waterman LA, Ward J, McCusker C, ZuWallack R, Baird JC. Validity and responsiveness of the self-administered computerized versions of the baseline and transition dyspnea indexes. Chest 2007; 132:1283-1290. (Pubitemid 47621005)
18. Miller MR, Crapo R,Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Enright P, Van Der Grinten CP, Gustafsson P, et al. General considerations for lung function testing. Eur Respir J 2005; 26:153-161. (Pubitemid 40945944)
19. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, Van Der Grinten CP, Gustafsson P, et al. Standardisation of spirometry. Eur Respir J 2005; 26:319-338. (Pubitemid 41079078)
20. Macintyre N, Crapo RO, Viegi G, Johnson DC, Van Der Grinten CP, Brusasco V, Burgos F, Casaburi R, Coates A, Enright P, et al. Standardisation of the single-breath determination of carbon monoxide uptake in the lung. Eur Respir J 2005; 26:720-735. (Pubitemid 41448672)
21. Black LF, Hyatt RE. Maximal respiratory pressures: Normal values and relationship to age and sex. Am Rev Respir Dis 1969; 99:696-702.
22. Morris JF, KoskiA, Johnson LC. Spirometric standards for healthy nonsmoking adults. Am Rev Respir Dis 1971; 103:57-67.
23. Crapo RO, Morris AH, Gardner RM. Reference spirometric values using techniques and equipment that meet ATS recommendations. Am Rev Respir Dis 1981; 123:659-664. (Pubitemid 11117589)
24. Gaensler EA, Smith AA. Attachment for automated single breath diffusing capacity measurement. Chest 1973; 63:136-145.
25. O'Donnell DE, Revill SM,Webb KA. Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 164:770-777. (Pubitemid 32881912)
26. O'Donnell DE, Fluge T, Gerken F, Hamilton A, Webb K, AguilaniuB, Make B,MagnussenH.Effects of tiotropiumonlung hyperinflation, dyspnoea and exercise tolerance in COPD. Eur Respir J 2004; 23:832-840. (Pubitemid 38807355)
27. Pepin V, Saey D,Whittom F, LeBlanc P, Maltais F. Walking versus cycling: sensitivity to bronchodilation in chronic obstructive pulmonary disease. Am J Respir Crit CareMed 2005; 172:1517-1522. (Pubitemid 43076539)
28. Ayers ML, Mejia R, Ward J, Lentine T, Mahler DA. Effectiveness of salmeterol versus ipratropium bromide on exertional dyspnoea in COPD. Eur Respir J 2001; 17:1132-1137. (Pubitemid 32717469)
29. O'Donnell DE, Sciurba F, Celli B, Mahler DA,Webb KA, Kalberg CJ, Knobil K. Effect of fluticasone propionate/salmeterol on lung hyperinflation and exercise endurance in COPD. Chest 2006; 130:647-656. (Pubitemid 44423592)
30. Somfay A, Porszasz J, Lee SM, Casaburi R. Dose-response effect of oxygen on hyperinflation and exercise endurance in nonhypoxaemic COPD patients. Eur Respir J 2001; 18:77-84. (Pubitemid 32717434)
31. Wan L, Van Diest I, De Peuter S, Bogaerts K, Van Den Bergh O. Repeated breathlessness experiences induced by hypercapnia: differential effects on intensity and unpleasantness. Chest 2009; 135:455-461.
32. Oga T, Nishimura K, Tsukino M, Hajiro T, Ikeda A, Izumi T. The effects of oxitropium bromide on exercise performance in patients with stable chronic obstructive pulmonary disease. A comparison of three different exercise tests. Am J Respir Crit Care Med 2000; 161:1897-1901. (Pubitemid 30418126)
33. Brouillard C, Pepin V, Milot J, Lacasse Y, Maltais F. Endurance shuttle walking test: responsiveness to salmeterol in COPD. Eur Respir J 2008; 31:579-584.
34. Clement-Jones V, Besser GM. Clinical perspectives in opioid peptides. Br Med Bull 1983; 39:95-100. (Pubitemid 13220734)
35. LeMerrer J, Becker JA, Befort K, Kieffer BL. Reward processing by the opioid system in the brain. Physiol Rev 2009; 89:1379-1412.
36. Zebraski SE, Kochenash SM, Raffa RB. Lung opioid receptors: pharmacology and possible target for nebulized morphine in dyspnea. Life Sci 2000; 66:2221-2231. (Pubitemid 30256621)
37. Mahler DA, Selecky PA, Harrod CG, Benditt JO, Carrieri- Kohlman V, Curtis JR,Manning HL, Mularski RA, CampbellM, Carter ER, et al. American College of Chest Physicians consensus statement on the management of dyspnea in patients with advanced lung or heart disease. Chest 2010; 137:674-691.
38. Varkey B. Opioids for palliation of refractory dyspnea in chronic obstructive pulmonary disease patients. Curr Opin Pulm Med 2010; 16:150-154.
39. Chonan T, Altose MD, Cherniack NS. Effects of expiratory resistive loading on the sensation of dyspnea. J Appl Physiol 1990; 69:91-95. (Pubitemid 20230947)
40. Stevenson NJ, Walker PP, Costello RW, Calverley PM. Lung mechanics and dyspnea during exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005; 172:1510-1516. (Pubitemid 43076538)
41. Parker CM, VoducN,Aaron SD,WebbKA, O'DonnellDE. Physiological changes during symptom recovery from moderate exacerbations of COPD. Eur Respir J 2005; 26:420-428. (Pubitemid 41264203)
42. Ofir D, Laveneziana P,Webb KA, O'DonnellDE. Ventilatory and perceptual responses to cycle exercise in obese women. J Appl Physiol 2007; 102:2217-2226. (Pubitemid 47080753)
43. Mahler DA, Ward J, Fierro-Carrion G, Waterman L, Lentine TF, Mejia-Alfaro R, Baird JC. Development of self-administered versions of the modified baseline and transition dyspnea indexes in COPD. J COPD 2004; 1:165-172.