Coagulation potential of immobilised factor VIII in flow-dependent fibrin generation on platelet surfaces

Thrombosis and Haemostasis

Volumn 110, Issue 2, 2013, Pages 316-322

  Doi, Masaaki ^a   Sugimoto, Mitsuhiko ^a   Matsui, Hideto ^a   Matsunari, Yasunori ^a   Shima, Midori ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

Factor VIII; Fibrin generation; Flow; Haemophilia; von Willebrand factor

Indexed keywords

ARGATROBAN; BLOOD CLOTTING FACTOR 8; CITRATE SODIUM; FIBRIN; RECOMBINANT BLOOD CLOTTING FACTOR 8; VON WILLEBRAND FACTOR;

ARTICLE; BLOOD CLOTTING; BLOOD FLOW; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMOPHILIA A; HUMAN; NORMAL HUMAN; PRIORITY JOURNAL; SHEAR RATE; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOCYTE MEMBRANE; THROMBUS;

BLOOD COAGULATION; BLOOD PLATELETS; FACTOR VIII; FIBRIN; HEMOPHILIA A; HEMORHEOLOGY; HUMANS; IMMOBILIZED PROTEINS; PERFUSION; PLATELET ADHESIVENESS; PLATELET AGGREGATION; SURFACE PROPERTIES; THROMBOSIS; VON WILLEBRAND FACTOR;

EID: 84880764312     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH13-02-0159     Document Type: Article

References (22)

1. Sixma JJ, Waster J. The hemostatic plug. Semin Hematol 1977; 14: 265-299.
2. Weiss HJ. Platelet physiology and abnormalities of platelet function. N Engl J Med 1975; 293: 531-541.
3. Furie B, Furie BC. Thrombus formation in vivo. J Clin Invest 2005; 115: 3355-3362.
4. Davie EW, Ratnoff OD. Waterfall sequence for intrinsic blood clotting. Science 1964; 145: 1310-1312.
5. Hoyer L. The factor VIII complex: Structure and function. Blood 1981; 58: 1-13.
6. Fay PJ. Factor VIII structure and function. Int J Hematol 2006; 83: 103-108.
7. Mizuno T, Sugimoto M, Matsui H, et al. Visual evaluation of blood coagulation during mural thrombogenesis under high shear flow. Thromb Res 2008; 121: 855-864.
8. Hamada M, Sugimoto M, Matsui H, et al. Antithrombotic properties of pravastatin reducing intra-thrombus fibrin deposition under high shear blood flow conditions. Thromb Haemost 2011; 105: 313-320.
9. Sugimoto M, Mohri H, McClintock RA, et al. Identification of discontinuous von Willebrand factor sequences involved in complex formation with botrocetin. A model for the regulation of von Willebrand factor binding to platelet glycoprotein Ib. J Biol Chem 1991; 266: 18172-18178.
10. Weiss HJ, Sussman II, Hoyer LW. Stabilisation of factor VIII in plasma by the von Willebrand factor: Studies on posttransfusion and dissociated factor VIII and in patients with von Willebrand's disease. J Clin Invest 1977; 60: 390-404.
11. Kamisue S, Shima M, Nishimura T, et al. Abnormal factor VIII Hiroshima: defect in crucial proteolytic cleavage by thrombin at Arg1689 detected by a novel ELISA. Br J Haematol 1994; 86: 106-111.
12. Kuwahara M, Sugimoto M, Tsuji S, et al. Cytosolic calcium changes in a process of platelet adhesion and cohesion on a von Willebrand factor-coated surface under flow conditions. Blood 1999; 94: 1149-1155.
13. Matsui H, Sugimoto M, Mizuno T, et al. Distinct and concerted functions of von Willebrand factor and fibrinogen in mural thrombus growth under high shear flow. Blood 2002; 100: 3604-3610.
14. Sugimoto M, Matsui H, Mizuno T, et al. Mural thrombus generation in type 2A and 2B von Willebrand disease under flow conditions. Blood 2003; 101: 915-920.
15. Shida Y, Nishio K, Sugimoto M, et al. Functional imaging of shear-dependent activity of ADAMTS13 in regulating mural thrombus growth under whole blood flow conditions. Blood 2008; 111: 1295-1298.
16. Tsuji S, Sugimoto M, Miyata S, et al. Real-time analysis of mural thrombus formation in various platelet aggregation disorders: distinct shear-dependent roles of platelet receptors and adhesive proteins under flow. Blood 1999; 94: 968-975.
17. Atkinson BT, Jasuja R, Chen VM, et al. Laser-induced endothelial cell activation supports fibrin formation. Blood 2010; 116: 4675-4683.
18. Sadler JE. Biochemistry and genetics of von Willebrand factor. [pic][pic]Ann Rev Biochem 1998; 67: 395-424.
19. Lenting PJ, van Mourick JA, Mertens K. The life cycle of coagulation factor VIII in view of its structure and function. Blood 1998; 92: 3983-3996.
20. Kuharsky A L, Fogelson A L. Surface-mediated control of blood coagulation: the role of binding site densities and platelet deposition. Biophys J 2001; 80: 1050-1074.
21. Berny MA, Munnix IC, Auger JM, et al. Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear. PLoS One 2010; 5: e10415.
22. Leiderman K, Fogelson AL. Grow with the flow: a spatial-temporal model of platelet deposition and blood coagulation under flow. Math Med Biol 2011; 28: 47-84.