Antithrombotic properties of pravastatin reducing intra-thrombus fibrin deposition under high shear blood flow conditions

Thrombosis and Haemostasis

Volumn 105, Issue 2, 2011, Pages 313-320

  Hamada, Masaaki ^a   Sugimoto, Mitsuhiko ^a   Matsui, Hideto ^a   Mizuno, Tomohiro ^a   Shida, Yasuaki ^a   Doi, Masaaki ^a   Fukushima, Hidetada ^a   Nishio, Kenji ^a   Yoshioka, Akira ^a   Shima, Midori ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

Fibrinogen fibrin; High fluid shear; Statins; Thrombus; Von Willebrand factor

Indexed keywords

ATORVASTATIN; FIBRIN; FIBRINOGEN; MEVALONIC ACID; PADGEM PROTEIN; PRAVASTATIN; THROMBIN; THROMBOPLASTIN; VON WILLEBRAND FACTOR;

ARTICLE; BLOOD FLOW; BLOOD SAMPLING; CARDIOVASCULAR RISK; CONCENTRATION RESPONSE; CONTROLLED STUDY; FIBRIN DEPOSITION; HUMAN; IN VITRO STUDY; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHEAR FLOW; SHEAR RATE; THROMBOCYTE ACTIVATION; THROMBUS;

BLOOD PLATELETS; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRIN; FIBRINOLYTIC AGENTS; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MEVALONIC ACID; P-SELECTIN; PERFUSION; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PRAVASTATIN; PYRROLES; REGIONAL BLOOD FLOW; STRESS, MECHANICAL; THROMBIN; THROMBOPLASTIN; THROMBOSIS; TIME FACTORS; VON WILLEBRAND FACTOR;

EID: 79851488376     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH10-09-0587     Document Type: Article

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