The decrease on Na+, K+-ATPase activity in the cortex, but not in hippocampus, is reverted by antioxidants in an animal model of sepsis

Molecular Neurobiology

Volumn 46, Issue 2, 2012, Pages 467-474

  Jeremias, Isabela Casagrande ^a   Scaini, Giselli ^a   Constantino, Larissa ^a   Vuolo, Francieli ^a   Ferreira, Andreia Kurek ^b   Scherer, Emilene Barros Silva ^b   Kolling, Janaina ^b   Da Silva Dornelles, Arethuza ^c   De Souza Wyse, Angela Terezinha ^b   Bogo, Maurício Reis ^c,d   Dal Pizzol, Felipe ^a,d   Streck, Emilio Luiz ^a,d  

^a UNIVERSIDADE DO EXTREMO SUL CATARINENSE   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d Instituto Nacional de Ciencia e Tecnologia Translacional em Medicina INCT TM   (Brazil)

Author keywords

Brain water content; Deferoxamine; N acetylcysteine; Sepsis

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ANTIOXIDANT; DEFEROXAMINE; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; BRAIN EDEMA; BRAIN WATER; CONTROLLED STUDY; DOWN REGULATION; HIPPOCAMPUS; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; RAT; SEPSIS;

EID: 84868101940     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-012-8297-2     Document Type: Article

References (44)

1. Vandijck D, Decruyenaere JM, Blot SI (2006) The value of sepsis definitions in daily ICU-practice. Acta Clin Belg 6:220-226 (Pubitemid 44912909)
2. Hotchkiss RS, Karl IE (2003) The pathophysiology and treatment of sepsis. N Engl J Med 348:138-142
3. Wheeler AP, Bernard GR (1999) Treating patients with severe sepsis. N Engl J Med 340:207-214 (Pubitemid 29063218)
4. Salvemini D, Cuzzocrea S (2002) Oxidative stress in septic shock and disseminated intravascular coagulation. Free Radic Biol Med 33:1173-1185 (Pubitemid 35246585)
5. Barichello T, Fortunato JJ, Vitali AM, Feier G, Reinke A, Moreira JC, Quevedo J, Dal-Pizzol F (2006) Oxidative variables in the rat brain after sepsis induced by cecal ligation and perforation. Crit Care Med 34:886-889
6. Andrades ME, Ritter C, Dal-Pizzol F (1994) The role of free radicals in sepsis development. Front Biosci 1:277
7. Ericinska M, Silver IA (1994) Silver, ions and energy in mammalian brain. Prog Neurobiol 16:37-71 (Pubitemid 24221854)
8. Lees GJ (1991) Inhibition of sodium-potassium-ATPase: a potentially ubiquitous mechanism contributing to central nervous system neuropathology. Brain Res Rev 16:283-300
9. Wyse AT, Streck EL, Barros SV, Brusque AM, Zugno AI, Wajner M (2000) Methylmalonate administration decreases Na+, K+-ATPase activity in cerebral cortex of rats. Neuroreport 11:2331-2334 (Pubitemid 30485586)
10. Wyse ATS, Streck EL, Worm P, Wajner A, Ritter F, Netto CA (2000) Preconditioning prevents the inhibition of Na+, K+-ATPase activity after brain ischemia. Neurochem Res 25:969-973
11. Yu SP (2003) Na+, K+-ATPase: the new face of an old player in pathogenesis and apoptotic/hybrid cell death. Biochem Pharmacol 66:1601-1609 (Pubitemid 38373352)
12. Hernandez JR (1992) Na+, K+-ATPase regulation by serotonin in normal and kindled rats. Brain Res 593:239-244
13. Yang ZJ, Torbey M, Li X, Bernardy J, Golden WC, Martin LJ, Koehler RC (2007) Dopamine receptor modulation of hypoxicischemic neuronal injury in striatum of newborn piglets. J Cereb Blood Flow Metab 27:1339-1351 (Pubitemid 46985351)
14. Kurella E, Kukley M, Tyulina O, Dobrota D, Matejovicova M, Mezesova V, Boldyrev A (1997) Kinetic parameters of Na+/K+-ATPase modified by free radicals in vitro and in vivo. Ann N Y Acad Sci 834:661-665 (Pubitemid 28009151)
15. Ritter C, Andrades ME, Reinke A, Menna-Barreto S, Moreira JC, Dal-Pizzol F (2004) Treatment with N-acetylcysteine plus deferoxamine protects rats against oxidative stress and improves survival in sepsis. Crit Care Med 32:342-349 (Pubitemid 38234109)
16. Ritter C, Andrades ME, Frota MLC, Bonatto F, Pinho RA, Polydoro M, Klamt F, Pinheiro CT, Menna-Barreto SS, Moreira JC, Dal-Pizzol F (2003) Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation. Intensive Care Med 29:1782-1789 (Pubitemid 37373825)
17. Barichello T, Martins MR, Reinke A, Feier G, Ritter C, Quevedo J, Dal-Pizzol F (2005) Cognitive impairment in sepsis survivors from cecal ligation and perforation. Crit Care Med 33:221-223 (Pubitemid 40116561)
18. Bradford MM (1976) A rapid and sensitive method for the quantification of micrograms quantities of protein utilizing the principle of protein-die-binding. Anal Biochem 72:248-254
19. Chan KM, Delfer D, Junger KD (1986) A direct colorimetric assay for Ca2+-stimulated ATPase activity. Anal Biochem 157:375-380 (Pubitemid 16027071)
20. Durmaz R, Ertilav K, Akyuz F, Kanbak G, Bildirici K, Tel E (2003) Lazaroid U-74389G attenuates edema in rat brain subjected to post-ischemic reperfusion injury. J Neurol Sci 215:87-93 (Pubitemid 37272202)
21. Zhang H, Slutsky AS, Vincent JL (2000) Oxygen free radicals in ARDS, septic shock and organ dysfunction. Intensive Care Med 26:474-476 (Pubitemid 30301532)
22. Zapelini PH, Rezin GT, Cardoso MR, Ritter C, Klamt F, Moreira JC, Streck EL, Dal-Pizzol F (2008) Antioxidant treatment reverses mitochondrial dysfunction in a sepsis animal model. Mitochondrion 8:211-218 (Pubitemid 351837489)
23. Joshi MS, Julian MW, Huff JE, Bauer JA, Xia Y, Crouser ED (2006) Calcineurin regulates myocardial function during acute endotoxemia. Am J Respir Crit Care Med 173:999-1007
24. Protti A, Carre J, Frost MT, Taylor V, Stidwill R, Rudiger A, Singer M (2007) Succinate recovers mitochondrial oxygen consumption in septic rat skeletal muscle. Crit Care Med 35:2150-2155 (Pubitemid 47326453)
25. Comim CM, Rezin GT, Scaini G, Di-Pietro PB, Cardoso MR, Petronilho FC, Ritter C, Streck EL, Quevedo J, Dal-Pizzol F (2008) Mitochondrial respiratory chain and creatine kinase activities in rat brain after sepsis induced by cecal ligation and perforation. Mitochondrion 8:313-318
26. Cassol OJ Jr, Rezin GT, Petronilho FC, Scaini G, Gonçalves CL, Ferreira GK, Roesler R, Schwartsmann G, Dal-Pizzol F, Streck EL (2010) Effects of N-acetylcysteine/deferoxamine, taurine and RC-3095 on respiratory chain complexes and creatine kinase activities in rat brain after sepsis. Neurochem Res 35:515-521
27. Barichello T, Machado RA, Constantino L, Valvassori SS, Réus GZ, Martins MR, Petronilho F, Ritter C, Quevedo J, Dal-Pizzol F (2007) Antioxidant treatment prevented late memory impairment in an animal model of sepsis. Crit Care Med 35:2186-2190 (Pubitemid 47326458)
28. Sweadner KJ (1979) Two molecular forms of Na(+) K(+)-stimulated ATPase in brain. Separation, and difference in affinity for strophanthidin. J Biol Chem 254:6060-6067 (Pubitemid 9242479)
29. Papadopoulos MC, Lamb FJ, Moss RF, Davies DC, Tighe D, Bennett ED (1999) Fecal peritonitis causes edema and neuronal injury in pig cerebral cortex. Clin Sci (Colch) 96:461-466 (Pubitemid 29237895)
30. Comim CM, Vilela MC, Constantino LS, Petronilho F, Vuolo F, Lacerda-Queiroz N, Rodrigues DH, da Rocha JL, Teixeira AL, Quevedo J, Dal-Pizzol F (2011) Traffic of leukocytes and cytokine up-regulation in the central nervous system in sepsis. Intensive Care Med 37:711-718
31. Wang XQ, Xiao AY, Sheline C, Hyrc K, Yang A, Goldberg MP, Choi DW, Yu SP (2003) Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress. J Cell Sci 116:2099-2110 (Pubitemid 36622306)
32. Beguin P, Beggah AT, Chibalin AV, Burgener-Kairuz P, Jaisser F, Mathews PM, Rossier BC, Cotecchia S, Geering K (1994) Phosphorylation of the Na, K-ATPase alpha-subunit by protein kinase A and C in vitro and in intact cells. Identification of a novel motif for PKC-mediated phosphorylation. J Biol Chem 269:24437-24445
33. Feschenko MS, Sweadner KJS (1995) Structural basis for species-specific differences in the phosphorylation of Na, K-ATPase by protein kinase C. J Biol Chem 270:14072-14077
34. Robinson JD, Pratap PR (1993) Indicators of conformational changes in the Na+/K(+)-ATPase and their interpretation. Biochim Biophys Acta 1154:83-104 (Pubitemid 23171391)
35. Logvinenko NS, Dulubova I, Fedosova N, Larsson SH, Nairn AC, Esmann M, Greengard P, Aperia A (1996) Phosphorylation by protein kinase C of serine-23 of the α-1 subunit of rat Na+, K+-ATPase affects its conformational equilibrium. Proc Natl Acad Sci USA 93:9132-9137 (Pubitemid 26282030)
36. Mishra OP, Delivoria-Papadopoulos M, Cahillane G, Wagerle LC (1989) Lipid peroxidation as the mechanism of modification of the affinity of the Na+, K+-ATPase active sites for ATP, K1, Na1, and strophanthidin in vitro. Neurochem Res 14:845-851 (Pubitemid 19274838)
37. Viani P, Cervato G, Fiorilli A, Cestaro B (1991) Agerelated differences in synaptosomal peroxidative damage and membrane properties. J Neurochem 56:253-258 (Pubitemid 21901957)
38. Yufu K, Itoh T, Edamatsu R, Mori A, Hirakawa M (1993) Effect of hyperbaric oxygenation on the Na+, K+-ATPase and membrane fluidity of cerebrocortical membranes after experimental subarachnoid hemorrhage. Neurochem Res 16:1033-1039 (Pubitemid 23220481)
39. Perl M, Chung CS, Swan R, Ayala A (2007) Role of programmed cell death in the immunopathogenesis of sepsis. Drug Discov Today Dis Mech 4:223-230
40. Ayala A, Perl M, Venet F, Lomas-Neira J, Swan R, Chung CS (2008) Apoptosis in sepsis: mechanisms, clinical impact and potential therapeutic targets. Curr Pharm Des 14:1853-1859
41. Messaris E, Memos N, Chatzigianni E, Konstadoulakis MM, Menenakos E, Katsaragakis S, Voumvourakis C, Androulakis G (2004) Time-dependent mitochondrial mediated programmed neuronal cell death prolongs survival in sepsis. Crit Care Med 32:1764-1770 (Pubitemid 39050530)
42. Sharshar T, Annane D, de laGrandmaison GF, Brouland JP, Hopkinson NS, Gray F (2004) The neuropathology of septic shock. Brain Pathol 14:21-33 (Pubitemid 38200586)
43. Semmler A, Okulla T, Sastre M, Dumitrescu-Ozimek L, Heneka MT (2005) Systemic inflammation induces apoptosis with variable vulnerability of different brain regions. J Chem Neu 30:144-157 (Pubitemid 41338695)
44. Heyland DK, Hopman W, Coo H, Tranmer J, McColl MA (2000) Long-term health-related quality of life in survivors of sepsis. Short Form 36: a valid and reliable measure of health-related quality of life. Crit Care Med 28:3599-3605