Arsenic trioxide toxicity in H9c2 myoblasts - Damage to cell organelles and possible amelioration with boerhavia diffusa

Cardiovascular Toxicology

Volumn 13, Issue 2, 2013, Pages 123-137

  Vineetha, V P ^a   Prathapan, A ^a   Soumya, R S ^a   Raghu, K G ^a  

^a REGIONAL RESEARCH LABORATORY CSIR   (India)

Author keywords

Arsenic trioxide; Boerhavia diffusa; H9c2; Intracellular calcium; Mitochondria; Oxidative stress

Indexed keywords

ALCOHOL; ARSENIC TRIOXIDE; BOERHAAVIA DIFFUSA EXTRACT; F ACTIN; LACTATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CARDIOTOXICITY; CELL ORGANELLE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; EMBRYO; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; HEART MUSCLE CELL; LYSOSOME; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; ARSENICALS; CALCIUM SIGNALING; CARDIOMYOPATHIES; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; MEMBRANE POTENTIAL, MITOCHONDRIAL; MYOBLASTS, CARDIAC; NYCTAGINACEAE; ORGANELLES; OXIDATIVE STRESS; OXIDES; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS; REACTIVE OXYGEN SPECIES;

BOERHAVIA DIFFUSA;

EID: 84880761147     PISSN: 15307905     EISSN: 15590259     Source Type: Journal    
DOI: 10.1007/s12012-012-9191-x     Document Type: Article

References (32)

1. Soignet, S. L.; Maslak, P.; Wang, Z. G.; Jhanwar, S.; Calleja, E.; Dardashti, L. J.; et al. (1998). Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide. The New England Journal of Medicine, 339, 1341-1348. (Pubitemid 28509343)
2. Tallman, M. S.; & Altman, J. K. (2008). Curative strategies in acute promyelocytic leukemia. Haematology, 1, 391-399.
3. Ducas, R. A.; Seftel, M. D.; Ducas, J.; & Seifer, C. (2011). Monomorphic ventricular tachycardia caused by arsenic trioxide therapy for acute promyelocytic leukaemia. The Journal of the Royal College of Physicians of Edinburgh, 41, 117-118.
4. Paul, M. K.; Kumar, R.; & Mukhopadhyay, A. K. (2008). Dithiothreitol abrogates the effect of arsenic trioxide on normal rat liver mitochondria and human hepatocellular carcinoma cells. Toxicology and Applied Pharmacology, 226(2), 140-152. (Pubitemid 350297346)
5. Lu, J.; Chew, E. H.; & Holmgren, A. (2007). Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide. P. Proceedings of the National Academy of Sciences of the United States of America, 104, 12288-12293. (Pubitemid 47206130)
6. Miller, W. H.; Schipper, H. M.; Lee, J. S.; Singer, J.; & Waxman, S. (2002). Mechanisms of action of arsenic trioxide. Cancer Research, 62, 3893-3903. (Pubitemid 34792653)
7. Sumi, D.; Shinkai, Y.; & Kumagai, Y. (2010). Signal transduction pathways and transcription factors triggered by arsenic trioxide in leukemia cells. Toxicology and Applied Pharmacology, 244, 385-392.
8. Raghu, K. G.; Yadav, G. K.; Singh, R.; Prathapan, A.; Sharma, S.; & Bhadauria, S. (2009). Evaluation of adverse cardiac effects induced by arsenic trioxide, a potent anti-APL drug. The Journal of Environmental Pathology, Toxicology and Oncology, 28, 241-252.
9. Tiwari, H.; & Rao, M. V. (2010). Curcumin supplementation protects from genotoxic effects of arsenic and fluoride. Food and Chemical Toxicology, 48, 1234-1238.
10. Zhao, X. Y.; Li, G. Y.; Liu, Y.; Chai, L. M.; Chen, J. X.; Zhang, Y.; et al. (2008). Resveratrol protects against arsenic trioxide-induced cardiotoxicity in vitro and in vivo. British Journal of Pharmacology, 154, 105-113. (Pubitemid 351620407)
11. Kumazaki, M.; Ando, H.; Sasaki, A.; Koshimizu, T. A.; Ushijima, K.; Hosohata, K.; et al. (2011). Protective effect of α-lipoic acid against arsenic trioxide-induced acute cardiac toxicity in rats. Journal of Pharmacological Sciences, 115, 244-248.
12. Patwardhan, B.; Warude, D.; Pushpagandhan, P.; & Bhatta, N. (2005). Ayurveda and traditional Chinese medicine: A comparative overview. Evidence-Based Complementary and Alternative Medicine, 2, 465-473. (Pubitemid 41752482)
13. Leyon, P. V.; Lini, C. C.; & Kuttan, G. (2005). Inhibitory effect of Boerhaavia diffusa on experimental metastasis by B16F10 melanoma in C57BL/6 mice. Life Sciences, 76, 1339-1349.
14. Gopal, T. K.; Harish, G.; Chamundeeswari, D.; & Reddy, C. U. (2010). In-vitro antioxidant activity of roots of Boerhaavia diffusa Linn. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 1, 782-788.
15. Prathapan, A.; Singh, M. K.; Anusree, S. S.; Kumar, D. R. S.; Sundaresan, A.; & Raghu, K. G. (2011). Antiperoxidative, free radical scavenging and metal chelating activities of Boerhaavia diffusa L. Journal of Food Biochemistry, 35, 1548-1554.
16. Rajpoot, K.; & Mishra, R. N. (2011). Boerhaavia diffusa roots (Punarnava mool) - Review as rasayan (rejuvenator/antiaging). International Journal of Pharmaceutical and Biomedical Research, 2, 1451-1460.
17. Misra, H. P.; & Fridovich, I. (1972). The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. Journal of Biological Chemistry, 247, 3170-3175.
18. Cohen, G.; Dembiec, D.; & Marcus, J. (1970). Measurement of catalase activity in tissue extract. Analytical Biochemistry, 34, 30-37.
19. Antman, K. H. (2001). Introduction: The history of arsenic trioxide in cancer therapy. The Oncologist, 6, 1-2. (Pubitemid 32405842)
20. Ficker, E.; Kuryshev, Y. A.; Dennis, A. T.; Obejero-Paz, C.; Wang, Lu, Hawryluk, P.; et al. (2004). Mechanisms of arsenic-induced prolongation of cardiac repolarization. Molecular Pharmacology, 66, 33-44. (Pubitemid 38822085)
21. Li, Y.; Sun, X.; Wang, L.; Zhou, Z.; & Kang, Y. J. (2002). Myocardial toxicity of arsenic trioxide in a mouse model. Cardiovascular Toxicology, 2, 63-73. (Pubitemid 37070573)
22. Hescheler, J.; Meyer, R.; Plant, S.; Krautwurst, D.; Rosenthal, W.; & Schultz, G. (1991). Morphological, biochemical and electrophysiological characterization of a clonal cell (H9c2) line from rat heart. Circulation Research, 69, 1476-1486.
23. Agrawal, B.; Das, S.; & Pandey, A. (2011). Boerhaavia diffusa Linn: A review on its phytochemical and pharmacological profile. Asian Journal of Applied Sciences, 4, 663-684.
24. Pandey, R.; Maurya, R.; Singh, G.; Sathiamoorthy, B.; & Naik, S. (2005). Immunosuppressive properties of flavonoids isolated from Boerhaavia diffusa (Linn). International Immunopharmacology, 5, 541-553. (Pubitemid 40430761)
25. Agrawal, B.; Das, S.; & Shukla, A. K. (2011). Active component from ethanolic extract of Boerhaavia diffusa. Proceedings of the National conference on recent development in material science. Feb. 11-12, F. G. College, Raebareli, India. pp. 82-82.
26. Maurya, R.; Sathiamoorthy, B.; & Deepak, M. (2007). Flavonoids and phenyl glycosides from Boerhaavia diffusa. Natural Product Research, 21, 126-134. (Pubitemid 47161241)
27. Kirkinezosa, I. G.; & Moraes, C. T. (2001). Reactive oxygen species and mitochondrial diseases. Cell and Developmental Biology, 12, 449-457.
28. Baj, G.; Arnulfo, A.; & Deaglio, S. (2002). Arsenic trioxide and breast cancer: analysis of the apoptotic, differentiative and immunomodulatory effects. Breast Cancer Research and Treatment, 73, 61-73. (Pubitemid 34548166)
29. Florea, A. M.; & Busselberg, D. (2009). Anti-cancer drugs interfere with intracellular calcium signalling. Neurotoxicology, 30, 803-810.
30. Zhao, X.; Feng, T.; Chen, H.; Shan, H.; Zhang, Y.; Lu, Y.; et al. (2008). Arsenic trioxide-induced apoptosis in H9c2 cardiomyocytes: implications in cardiotoxicity. Basic & Clinical Pharmacology & Toxicology, 102, 419-425. (Pubitemid 351537783)
31. Auner, H. W.; Schmid, C. B.; Dillon, N.; & Sabbattini, P. (2010). The life span of short-lived plasma cells is partly determined by a block on activation of apoptotic caspases acting in combination with endoplasmic reticulum stress. Blood, 116, 3445-3455.
32. Kitareewan, S.; Roebuck, B. D.; Demidenko, E.; Sloboda, R. D.; & Dmitrovsky, E. (2007). Lysosomes and trivalent arsenic treatment in acute promyelocytic leukemia. Journal of the National Cancer Institute, 99, 41-52.