Angiotensin II promotes thoracic aortic dissections and ruptures in col3a1 haploinsufficient mice

Hypertension

Volumn 62, Issue 1, 2013, Pages 203-208

  Faugeroux, Julie ^a,b   Nematalla, Hany ^c   Li, Weiwei ^a,b   Clement, Marc ^b,f,g   Robidel, Estelle ^a,b   Frank, Michael ^e   Curis, Emmanuel ^b,e   Ait Oufella, Hafid ^a,b   Caligiuri, Giuseppina ^b,g   Nicoletti, Antonino ^b,g   Hagege, Albert ^c   Messas, Emmanuel ^b   Bruneval, Patrick ^a,b,d   Jeunemaitre, Xavier ^a,e   Bergaya, Sonia ^a,b  

^a PARIS CARDIOVASCULAR RESEARCH CENTER   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c Service de Cardiologie   (France)

^d Service d'Anatomo pathologie   (France)

^e ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^f HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^g INSERM   (France)

Author keywords

angiotensin II; aortic dissection and rupture; collagens type III and type I; mouse model; vascular Ehlers Danlos syndrome

Indexed keywords

ANGIOTENSIN II; COLLAGEN FIBRIL; COLLAGEN TYPE 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA DISSECTION; AORTA RUPTURE; ARTICLE; CARDIOVASCULAR MORTALITY; COMPARATIVE STUDY; DRUG INDUCED DISEASE; ECHOCARDIOGRAPHY; GENETIC SUSCEPTIBILITY; HISTOLOGY; HYPERTENSION; MOUSE; NONHUMAN; PREMATURE MORTALITY; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; THORACIC AORTA SURGERY;

ANGIOTENSIN II; AORTIC DISSECTION AND RUPTURE; COLLAGENS TYPE III AND TYPE I; MOUSE MODEL; VASCULAR EHLERS-DANLOS SYNDROME;

ANEURYSM, DISSECTING; ANEURYSM, RUPTURED; ANGIOTENSIN II; ANIMALS; AORTA, THORACIC; AORTIC RUPTURE; COLLAGEN TYPE III; DISEASE MODELS, ANIMAL; DNA; DNA MUTATIONAL ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; EHLERS-DANLOS SYNDROME; HAPLOINSUFFICIENCY; INFUSIONS, INTRAVENOUS; MICE; MUTATION;

EID: 84880732002     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.00974     Document Type: Article

References (23)

1. Beighton P, De Paepe A, Steinmann B, Tsipouras P, Wenstrup RJ. Ehlers- Danlos syndromes: revised nosology, Villefranche, 1997. Ehlers-Danlos National Foundation (USA) and Ehlers-Danlos Support Group (UK). Am J Med. Genet. 1998;77:31-37.
2. Watanabe A, Shimada T. Vascular type of Ehlers-Danlos syndrome. J Nippon Med Sch. 2008;75:254-261.
3. Pepin M, Schwarze U, Superti-Furga A, Byers PH. Clinical and genetic features of Ehlers-Danlos syndrome type IV, the vascular type. N Engl J Med. 2000;342:673-680.
4. Leistritz DF, Pepin MG, Schwarze U, Byers PH. COL3A1 haploinsufficiency results in a variety of Ehlers-Danlos syndrome type IV with delayed onset of complications and longer life expectancy. Genet Med. 2011;13:717-722.
5. Barnes MJ, Farndale RW. Collagens and atherosclerosis. Exp Gerontol. 1999;34:513-525.
6. Dobrin PB, Baker WH, Gley WC. Elastolytic and collagenolytic studies of arteries. Implications for the mechanical properties of aneurysms. Arch Surg. 1984;119:405-409.
7. Germain DP. Ehlers-Danlos syndrome type IV. Orphanet J Rare Dis. 2007;2:32.
8. Beridze N, Frishman WH. Vascular Ehlers-Danlos syndrome: pathophysiology, diagnosis, and prevention and treatment of its complications. Cardiol Rev. 2012;20:4-7.
9. Lum YW, Brooke BS, Black JH 3rd. Contemporary management of vascular Ehlers-Danlos syndrome. Curr Opin Cardiol. 2011;26:494-501.
10. Ong KT, Perdu J, De Backer J, et al. Effect of celiprolol on prevention of cardiovascular events in vascular Ehlers-Danlos syndrome: a prospective randomised, open, blinded-endpoints trial. Lancet. 2010;376:1476-1484.
11. Liu X, Wu H, Byrne M, Krane S, Jaenisch R. Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc Natl Acad Sci USA. 1997;94:1852-1856.
12. Cooper TK, Zhong Q, Krawczyk M, Tae HJ, Müller GA, Schubert R, Myers LA, Dietz HC, Talan MI, Briest W. The haploinsufficient Col3a1 mouse as a model for vascular Ehlers-Danlos syndrome. Vet Pathol. 2010;47:1028-1039.
13. Briest W, Cooper TK, Tae HJ, Krawczyk M, McDonnell NB, Talan MI. Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome. J Pharmacol Exp Ther. 2011;337:621-627.
14. Tae HJ, Marshall S, Zhang J, Wang M, Briest W, Talan MI. Chronic treatment with a broad-spectrum metalloproteinase inhibitor, doxycycline, prevents the development of spontaneous aortic lesions in a mouse model of vascular Ehlers-Danlos syndrome. J Pharmacol Exp Ther. 2012;343:246-251.
15. Daugherty A, Manning MW, Cassis LA. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest. 2000;105:1605-1612.
16. Daugherty A, Cassis LA. Mouse models of abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol. 2004;24:429-434.
17. Francois H, Athirakul K, Mao L, Rockman H, Coffman TM. Role for thromboxane receptors in angiotensin-II-induced hypertension. Hypertension. 2004;43:364-369.
18. Owens AP 3rd, Subramanian V, Moorleghen JJ, Guo Z, McNamara CA, Cassis LA, Daugherty A. Angiotensin II induces a region-specific hyperplasia of the ascending aorta through regulation of inhibitor of differentiation 3. Circ Res. 2010;106:611-619.
19. Cassis LA, Gupte M, Thayer S, Zhang X, Charnigo R, Howatt DA, Rateri DL, Daugherty A. ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice. Am J Physiol Heart Circ Physiol. 2009;296:H1660-H1665.
20. Intengan HD, Schiffrin EL. Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis. Hypertension. 2001;38:581-587.
21. Rahkonen O, Su M, Hakovirta H, Koskivirta I, Hormuzdi SG, Vuorio E, Bornstein P, Penttinen R. Mice with a deletion in the first intron of the Col1a1 gene develop age-dependent aortic dissection and rupture. Circ Res. 2004;94:83-90.
22. Smith LB, Hadoke PW, Dyer E, Denvir MA, Brownstein D, Miller E, Nelson N, Wells S, Cheeseman M, Greenfield A. Haploinsufficiency of the murine Col3a1 locus causes aortic dissection: a novel model of the vascular type of Ehlers-Danlos syndrome. Cardiovasc Res. 2011;90:182-190.
23. Guo DC, Papke CL, He R, Milewicz DM. Pathogenesis of thoracic and abdominal aortic aneurysms. Ann N Y Acad Sci. 2006;1085:339-352.