Glyphosate and AMPA inhibit cancer cell growth through inhibiting intracellular glycine synthesis

Drug Design, Development and Therapy

Volumn 7, Issue , 2013, Pages 635-643

  Li, Qingli ^a,b   Lambrechts, Mark J ^a   Zhang, Qiuyang ^a   Liu, Sen ^a   Ge, Dongxia ^a   Yin, Rutie ^b   Xi, Mingrong ^b   You, Zongbing ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Apoptosis; Prostate cancer; Serine hydroxymethyltransferase

Indexed keywords

AMINOMETHYLPHOSPHONIC ACID; CASPASE 3; CYCLIN D3; GLYCINE; GLYPHOSATE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROCASPASE 9; PROTEIN P21; PROTEIN P53;

AMINO ACID SYNTHESIS; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CELL IMMORTALIZATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; ENZYME ACTIVATION; EPITHELIUM CELL; FEMALE; G0 PHASE CELL CYCLE CHECKPOINT; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; MALE; PROSTATE CANCER; PROSTATE EPITHELIUM; PROTEIN CLEAVAGE; UPREGULATION;

APOPTOSIS; PROSTATE CANCER; SERINE HYDROXYMETHYLTRANSFERASE;

APOPTOSIS; CELL CYCLE; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; EPITHELIAL CELLS; FEMALE; GLYCINE; HUMANS; MALE; NEOPLASMS; ORGANOPHOSPHONATES; PROSTATE; UP-REGULATION;

EID: 84880713282     PISSN: 11778881     EISSN: None     Source Type: Journal    
DOI: 10.2147/DDDT.S49197     Document Type: Article

References (24)

1. Nelson DL, Cox MM. 2008. Principles of Biochemistry. New York, NY: WH Freeman and Company; 2008.
2. Kerr SJ. Competing methyltransferase systems. J Biol Chem. 1972;247(13):4248-4252.
3. Porter DH, Cook RJ, Wagner C. Enzymatic properties of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver. Arch Biochem Biophys. 1985;243(2):396-407.
4. Hahn RG. Dose-dependent half-life of glycine. Urol Res. 1993;21(4): 289-291.
5. Jain M, Nilsson R, Sharma S, et al. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science. 2012;336(6084):1040-1044.
6. Garrow TA, Brenner AA, Whitehead VM, et al. Cloning of human cDNAs encoding mitochondrial and cytosolic serine hydroxymethyltransferases and chromosomal localization. J Biol Chem. 1993;268(16): 11910-11916.
7. Girgis S, Nasrallah IM, Suh JR, et al. Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyltransferase gene. Gene. 1998;210(2):315-324.
8. Stover PJ, Chen LH, Suh JR, Stover DM, Keyomarsi K, Shane B. Molecular cloning, characterization, and regulation of the human mitochondrial serine hydroxymethyltransferase gene. J Biol Chem. 1997;272(3):1842-1848.
9. Anderson DD, Stover PJ. SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis. PLoS One. 2009;4(6):e5839.
10. World Health Organization (WHO). Glyphosate and AMPA in Drinking-Water. Background Document for Development of WHO Guidelines for Drinking-Water Quality. Geneva: WHO; 2005.
11. World Health Organization (WHO). IPCS, Environmental Health Criteria 159: Glyphosate. Geneva: WHO; 1994.
12. Williams GM, Kroes R, Munro IC. Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans. Regul Toxicol Pharmacol. 2000;31(2 Pt 1):117-165.
13. You Z, Dong Y, Kong X, Zhang Y, Vessella RL, Melamed J. Differential expression of IL-17RC isoforms in androgen-dependent and androgen-independent prostate cancers. Neoplasia. 2007;9(6):464-470.
14. Thalmann GN, Sikes RA, Wu TT, et al. LNCaP progression model of human prostate cancer: androgen-independence and osseous metastasis. Prostate. 2000;44(2):91-103.
15. Crouch SP, Kozlowski R, Slater KJ, Fletcher J. The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity. J Immunol Methods. 1993;160(1):81-88.
16. Kangas L, Grönroos M, Nieminen AL. Bioluminescence of cellular ATP: a new method for evaluating cytotoxic agents in vitro. Med Biol. 1984;62(6):338-343.
17. Elisia I, Popovich DG, Hu C, Kitts DD. Evaluation of viability assays for anthocyanins in cultured cells. Phytochem Anal. 2008;19(6): 479-486.
18. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods. 1995;184(1):39-51.
19. Mead RN, Ryu J, Liu S, et al. Supraphysiologic temperature enhances cytotoxic effects of bupivacaine on bovine articular chondrocytes in an in vitro study. Arthroscopy. 2012;28(3):397-404.
20. He G, Siddik ZH, Huang Z, et al. Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities. Oncogene. 2005;24(18):2929-2943.
21. el-Deiry WS, Harper JW, O'Connor PM, et al. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 1994;54(5): 1169-1174.
22. el-Deiry WS, Tokino T, Velculescu VE, et al. WAF1, a potential mediator of p53 tumor suppression. Cell. 1993;75(4):817-825.
23. Fimognari C, Nusse M, Berti F, Iori R, Cantelli-Forti G, Hrelia P. Cyclin D3 and p53 mediate sulforaphane-induced cell cycle delay and apoptosis in non-transformed human T lymphocytes. Cell Mol Life Sci. 2002;59(11):2004-2012.
24. Sakai T, Liu L, Teng X, et al. Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of stress-induced apoptosis. J Biol Chem. 2004;279(39):41131-41140.