Elevated homocysteine levels are associated with low muscle strength and functional limitations in older persons

Journal of Nutrition, Health and Aging

Volumn 17, Issue 6, 2013, Pages 578-584

  Swart, K M A ^a   Van Schoor, N M ^a   Heymans, M W ^a   Schaap, L A ^a,b   Den Heijer, M ^a   Lips, P ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

aging; Homocysteine; muscle; physical functioning

Indexed keywords

CREATININE; HOMOCYSTEINE;

AGED; ARTICLE; CREATININE BLOOD LEVEL; FALLING; FEMALE; FOLLOW UP; FUNCTIONAL STATUS; GRIP STRENGTH; HUMAN; MAJOR CLINICAL STUDY; MALE; MUSCLE MASS; MUSCLE STRENGTH; PRIORITY JOURNAL; SEX DIFFERENCE; AGING; BLOOD; CROSS-SECTIONAL STUDY; HAND STRENGTH; LONGITUDINAL STUDY; PHYSIOLOGY; SKELETAL MUSCLE; VERY ELDERLY; WALKING;

AGED; AGED, 80 AND OVER; AGING; CREATININE; CROSS-SECTIONAL STUDIES; FEMALE; FOLLOW-UP STUDIES; HAND STRENGTH; HOMOCYSTEINE; HUMANS; LONGITUDINAL STUDIES; MALE; MUSCLE STRENGTH; MUSCLE, SKELETAL; WALKING;

EID: 84880709375     PISSN: 12797707     EISSN: 17604788     Source Type: Journal    
DOI: 10.1007/s12603-013-0047-2     Document Type: Article

References (41)

1. de Bree A, van der Put NMJ, Mennen LI, Verschuren WMM, Blom HJ, Galan P, Bates CJ, Herrmann W, Ullrich M, Dierkes J, Westphal S, Bouter LM, et al (2005) Prevalences of hyperhomocysteinemia, unfavorable cholesterol profile and hypertension in European populations. Eur J Clin Nutr 59:480-488.
2. Refsum H, Nurk E, Smith AD, Ueland PM, Gjesdal CG, Bjelland I, Tverdal A, Tell GS, Nygard O, Vollset SE (2006) The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease. J Nutr 136(6 Suppl):1731S-1740S.
3. Antoniades C, Antonopoulos AS, Tousoulis D, Marinou K, Stefanadis C (2009) Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials. Eur Heart J 30:6-15.
4. Durga J, van Boxtel MPJ, Schouten EG, Kok FJ, Jolles J, Katan MB, Verhoef P (2007) Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 369:208-216.
5. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PWF, Wolf PA (2002) Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 346:476-483.
6. Leboff MS, Narweker R, LaCroix A, Wu L, Jackson R, Lee J, Bauer DC, Cauley J, Kooperberg C, Lewis C, Thomas AM, Cummings S (2009) Homocysteine levels and risk of hip fracture in postmenopausal women. J Clin Endocrinol Metab 94:1207-1213.
7. McLean RR, Jacques PF, Selhub J, Fredman L, Tucker KL, Samelson EJ, Kiel DP, Cupples LA, Hannan MT (2008) Plasma B vitamins, homocysteine, and their relation with bone loss and hip fracture in elderly men and women. J Clin Endocrinol Metab 93:2206-2212.
8. van Meurs JBJ, Dhonukshe-Rutten RAM, Pluijm SMF, van der Klift M, de Jonge R, Lindemans J, de Groot LCPG, Hofman A, Witteman JCM, van Leeuwen JPTM, Breteler MMB, Lips P, et al (2004) Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 350:2033-2041.
9. Gerdhem P, Ivaska KK, Isaksson A, Pettersson K, Vaananen HK, Obrant KJ, Akesson K (2007) Associations between homocysteine, bone turnover, BMD, mortality, and fracture risk in elderly women. J Bone Miner Res 22:127-134.
10. Gjesdal CG, Vollset SE, Ueland PM, Refsum H, Drevon CA, Gjessing HK, Tell GS (2006) Plasma total homocysteine level and bone mineral density: the Hordaland Homocysteine Study. Arch Intern Med 166:88-94.
11. Morris MS, Jacques PF, Selhub J. Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans. Bone 2005 Aug;37(2):234-242.
12. Saito M, Fujii K, Marumo K (2006) Degree of mineralization-related collagen crosslinking in the femoral neck cancellous bone in cases of hip fracture and controls. Calcif Tissue Int 79:160-168.
13. Vaes BLT, Lute C, Blom HJ, Bravenboer N, de Vries TJ, Everts V, Dhonukshe-Rutten RA, Muller M, de Groot LCPG, Steegenga WT (2009). Vitamin B(12) deficiency stimulates osteoclastogenesis via increased homocysteine and methylmalonic acid. Calcif Tissue Int 84:413-422.
14. Kado DM, Bucur A, Selhub J, Rowe JW, Seeman T (2002) Homocysteine levels and decline in physical function: MacArthur Studies of Successful Aging. Am J Med 113:537-542.
15. Kuo HK, Liao KC, Leveille SG, Bean JF, Yen CJ, Chen JH, Yu YH, Tai TY (2007) Relationship of homocysteine levels to quadriceps strength, gait speed, and late-life disability in older adults. J Gerontol A Biol Sci Med Sci 62:434-439.
16. Rolita L, Holtzer R, Wang C, Lipton R, Derby C, Verghese J (2010) Homocysteine and Mobility in Older Adults. J Am Geriatr Soc 58:545-550.
17. Soumare A, Elbaz A, Ducros V, Tavernier B, Alperovitch A, Tzourio C (2006). Cross-sectional association between homocysteine and motor function in the elderly. Neurology 67:985-990.
18. van Schoor NM, Swart KMA, Pluijm SMF, Visser M, Simsek S, Smulders Y, Lips P (2012). Cross-sectional and longitudinal association between homocysteine, vitamin B12 and physical performance in older persons. Eur J Clin Nutr 66:174-181.
19. McDermott MM, Ferrucci L, Guralnik JM, Tian L, Green D, Liu K, Tan J, Liao Y, Pearce WH, Schneider JR, Ridker P, Rifai N, et al (2007) Elevated levels of inflammation, d-dimer, and homocysteine are associated with adverse calf muscle characteristics and reduced calf strength in peripheral arterial disease. J Am Coll Cardiol 50:897-905.
20. Marengoni A, Cossi S, De Martinis M, Calabrese PA, Orini S, Grassi V (2004) Homocysteine and disability in hospitalized geriatric patients. Metabolism 53:1016-1020.
21. Dhonukshe-Rutten RAM, Pluijm SMF, de Groot LCPG, Lips P, Smit JH, van Staveren WA (2005) Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people. J Bone Miner Res 20:921-929.
22. Sato Y, Honda Y, Iwamoto J, Kanoko T, Satoh K (2005) Effect of folate and mecobalamin on hip fractures in patients with stroke: a randomized controlled trial. JAMA 293:1082-1088.
23. Dierkes J, Jeckel A, Ambrosch A, Westphal S, Luley C, Boeing H (2001) Factors explaining the difference of total homocysteine between men and women in the European Investigation Into Cancer and Nutrition Potsdam study. Metabolism 50:640-645.
24. Huisman M, Poppelaars J, van der Horst M, Beekman A, Brug J, van Tilburg T, Deeg D (2011) Cohort Profile: The Longitudinal Aging Study Amsterdam. Int J Epidemiol 40:868-876.
25. Visser M, Fuerst T, Lang T, Salamone L, Harris TB (1999) Validity of fan-beam dual-energy X-ray absorptiometry for measuring fat-free mass and leg muscle mass. Health, Aging, and Body Composition Study - Dual-Energy X-ray Absorptiometry and Body Composition Working Group. J Appl Physiol 87:1513-1520.
26. Schaap LA, Pluijm SMF, Deeg DJH, Visser M (2006) Inflammatory markers and loss of muscle mass (sarcopenia) and strength. Am J Med 119:526-517.
27. Viitasalo J, Era P, Leskinen A, Heikkinen E (1985) Muscular strength profiles and anthropometry in random samples of men aged 31-35, 51-55 and 71-75 years. Ergonomics 28:1563-1574.
28. Avlund K, Schroll M, Davidsen M, Løvborg B, Rantanen T (1994) Maximal isometric muscle strength and functional ability in daily activities among 75-year-old men and women. Scand J Med Sci Sports 4:32-40.
29. van Sonsbeek J (1988) Methodological and substantial aspects of the OECD indicator of chronic functional limitations. Maandbericht Gezondheid (CBS) 88:4-17.
30. Garretsen H. Probleemdrinken, prevalentiebepaling, beinvloedende factoren en preventiemogelijkheden, theoretische overwegingen en onderzoek in Rotterdam. Lisse: Swets & Zeitlinger, 2003.
31. Stuck AE, Walthert JM, Nikolaus T, Bula CJ, Hohmann C, Beck JC (1999) Risk factors for functional status decline in community-living elderly people: a systematic literature review. Soc Sci Med 48:445-469.
32. Klinische Chemie. Kreatinine. In: VU medisch centrum, ed. Laboratoriumbepalingen 2012.
33. Myers AM, Holliday PJ, Harvey KA, Hutchinson KS (1993) Functional performance measures: are they superior to self-assessments? J Gerontol 48:M196-M206.
34. Elshorbagy AK, Nurk E, Gjesdal CG, Tell GS, Ueland PM, Nygard O, Tverdal A, Vollset SE, Refsum H (2008) Homocysteine, cysteine, and body composition in the Hordaland Homocysteine Study: does cysteine link amino acid and lipid metabolism? Am J Clin Nutr 88:738-746.
35. Clark BC, Manini TM (2008) Sarcopenia =/= dynapenia. J Gerontol A Biol Sci Med Sci 63:829-834.
36. Leishear K, Ferrucci L, Lauretani F, Boudreau RM, Studenski SA, Rosano C, Abbate R, Gori AM, Corsi AM, Di Iorio A, Guralnik JM, Bandinelli S, et al (2012) Vitamin B12 and homocysteine levels and 6-year change in peripheral nerve function and neurological signs. J Gerontol A Biol Sci Med Sci 67:537-543.
37. Mudd SH, Brosnan JT, Brosnan ME, Jacobs RL, Stabler SP, Allen RH, Vance DE, Wagner C (2007). Methyl balance and transmethylation fluxes in humans. Am J Clin Nutr 85:19-25.
38. Tarnopolsky MA (2000). Potential benefits of creatine monohydrate supplementation in the elderly. Curr Opin Clin Nutr Metab Care 3:497-502.
39. Chatthanawaree W (2011) Biomarkers of cobalamin (vitamin B12) deficiency and its application. J Nutr Health Aging 15:227-231.
40. Donders AR, van der Heijden GJMG, Stijnen T, Moons KGM (2006) Review: a gentle introduction to imputation of missing values. J Clin Epidemiol 59:1087-1091.
41. Swart KMA, van Schoor NM, Blom HJ, Smulders YM, Lips P (2012) Homocysteine and the risk of nursing home admission and mortality in older persons. Eur J Clin Nutr 66:188-195.