The role of the α7 subunit of the nicotinic acetylcholine receptor in the acute toxicosis of methyllycaconitine in mice

Journal of Applied Toxicology

Volumn 33, Issue 9, 2013, Pages 1011-1016

  Welch, K D ^a   Green, B T ^a   Panter, K E ^a   Pfister, J A ^a   Gardner, D R ^a  

^a USDA ARS POISONOUS PLANT RESEARCH LABORATORY   (United States)

Author keywords

7 nAChR; Anabasine; Delphinium; Larkspur; LD50; Methyllycaconitine

Indexed keywords

ANABASINE; BUNGAROTOXIN RECEPTOR; METHYLLYCACONITINE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; INTOXICATION; LD 50; MALE; MOUSE; NEUROMUSCULAR SYNAPSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE;

Α7 NACHR; ANABASINE; DELPHINIUM; LARKSPUR; LD50; METHYLLYCACONITINE;

ACONITINE; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ANIMALS; BRAIN; FEMALE; LETHAL DOSE 50; LOGISTIC MODELS; MALE; MICE; MICE, KNOCKOUT; TOXICITY TESTS, ACUTE;

DELPHINIUM; MUS;

EID: 84880701306     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.2851     Document Type: Article

References (31)

1. Alkondon M, Pereira EF, Wonnacott S, Albuquerque EX. 1992. Blockade of nicotinic currents in hippocampal neurons defines methyllycaconitine as a potent and specific receptor antagonist. Mol. Pharmacol. 41: 802-808.
2. Benn MH, Jacyno JM. 1983. The toxicology and pharmacology of diterpenoid alkaloids. In Alkaloids: Chemical and Biological Perspective, Pelletier SW (ed.). JohnWiley and Sons: New York, NY; 153-210.
3. Bourdi M, Eiras DP, Holt MP, Webster MR, Reilly TP, Welch KD, Pohl LR. 2007. Role of IL-6 in an IL-10 and IL-4 double knockout mouse model uniquely susceptible to acetaminophen-induced liver injury. Chem. Res. Toxicol. 20: 208-216.
4. Bruce RD. 1987. A confirmatory study of the up-and-down method for acute oral toxicity testing. Fundam. Appl. Toxicol. 8: 97-100.
5. Burrows GE, Tyrl R J. 2001. Toxic Plants of North America. Iowa State University Press: Ames, Iowa.
6. Clemens KJ, Caille S, Stinus L, Cador M. 2009. The addition of five minor tobacco alkaloids increases nicotine-induced hyperactivity, sensitization and intravenous self-administration in rats. Int. J. Neuropsychopharmacol. 12: 1355-1366.
7. Daly JW. 2005. Nicotinic agonists, antagonists, and modulators from natural sources. Cell. Mol. Neurobiol. 25: 513-552.
8. Dobelis P, Madl JE, Pfister JA, Manners GD, Walrond JP. 1999. Effects of Delphinium alkaloids on neuromuscular transmission. J. Pharmacol. Exp. Ther. 291: 538-546.
9. Franceschini D, Paylor R, Broide R, Salas R, Bassetto L, Gotti C, De B M. 2002. Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures. Brain Res. Mol. Brain Res. 98: 29-40.
10. Gahring LC, Rogers SW. 2008. Nicotinic acetylcholine receptor expression in the hippocampus of 27 mouse strains reveals novel inhibitory circuitry. Hippocampus 18: 737-749.
11. Gonzalez FJ. 2001. The use of gene knockout mice to unravel the mechanisms of toxicity and chemical carcinogenesis. Toxicol. Lett. 120: 199-208.
12. Green BT, Welch KD, Cook D, Gardner DR. 2011. Potentiation of the actions of acetylcholine, epibatidine, and nicotine by methyllycaconitine at fetal muscle-type nicotinic acetylcholine receptors. Eur. J. Pharmacol. 662: 15-21.
13. Keeler RF, Crowe MW, Lambert EA. 1984. Teratogenicity in swine of the tobacco alkaloid anabasine isolated from Nicotiana glauca. Teratology 30: 61-69.
14. Klink R, de Kerchove D A, Zoli M, Changeux JP. 2001. Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J. Neurosci. 21: 1452-1463.
15. Lesarri A, Cocinero EJ, Evangelisti L, Suenram RD, Caminati W, Grabow JU. 2010. The conformational landscape of nicotinoids: solving the conformational disparity of anabasine. Chemistry 16: 10214-10219.
16. Lopez MG, Montiel C, Herrero CJ, Garcia-Palomero E, Mayorgas I, Hernandez-Guijo J M, Villarroya M, Olivares R, Gandia L, McIntosh JM, Olivera BM, Garcia AG. 1998. Unmasking the functions of the chromaffin cell alpha7 nicotinic receptor by using short pulses of acetylcholine and selective blockers. Proc. Natl. Acad. Sci. U. S. A. 95: 14184-14189.
17. Macallan DR, Lunt GG, Wonnacott S, Swanson KL, Rapoport H, Albuquerque EX. 1988. Methyllycaconitine and (+)-anatoxin-a differentiate between nicotinic receptors in vertebrate and invertebrate nervous systems. FEBS Lett. 226: 357-363.
18. Manners GD, Panter KE, Ralphs MH, Pfister JA, Olsen JD, James LF. 1993. Toxicity and chemical phenology of norditerpenoid alkaloids in the tall larkspurs (Delphinium species). J. Agric. Food Chem. 41: 96-100.
19. Orr-Urtreger A, Broide RS, Kasten MR, Dang H, Dani JA, Beaudet AL, Patrick JW. 2000. Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth. J. Neurochem. 74: 2154-2166.
20. Orr-Urtreger A, Goldner FM, Saeki M, Lorenzo I, Goldberg L, De Biasi M, Dani JA, Patrick JW, Beaudet AL. 1997. Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents. J. Neurosci. 17: 9165-9171.
21. Pelletier SW, Kulanthaivel P, Olsen JD. 1989. Alkaloids of Delphinium Barbeyi. Phytochemistry 28: 1521-1525.
22. Reilly TP, Brady JN, Marchick MR, Bourdi M, George JW, Radonovich MF, Pise-Masison CA, Pohl LR. 2001. A protective role for cyclooxygenase-2 in drug-induced liver injury in mice. Chem. Res. Toxicol. 14: 1620-1628.
23. Rogers SW, Weis JJ, Ma Y, Teuscher C, Gahring LC. 2008. Mouse chromosome 11 harbors genetic determinants of hippocampal strain-specific nicotinic receptor expression. Hippocampus 18: 750-757.
24. Routtenberg A. 1995. Knockout mouse fault lines. Nature 374: 314-315.
25. Stegelmeier BL, Hall JO, Gardner DR, Panter KE. 2003. The toxicity and kinetics of larkspur alkaloid, methyllycaconitine, in mice. J. Anim. Sci. 81: 1237-1241.
26. Stegelmeier BL, Panter KE, Pfister JA, James LF, Manners GD, Gardner DR, Ralphs MH, Olsen JD. 1998. Experimental modification of larkspur (Delphinium spp.) poisoning in livestock. In Toxic Plants and Other Natural Toxicants, Garland TR, Barr AC (eds). CAB International: New York, New York; 205-210.
27. Tritto T, McCallum SE, Waddle SA, Hutton SR, Paylor R, Collins AC, Marks MJ. 2004. Null mutant analysis of responses to nicotine: deletion of beta2 nicotinic acetylcholine receptor subunit but not alpha7 subunit reduces sensitivity to nicotine-induced locomotor depression and hypothermia. Nicotine Tob. Res. 6: 145-158.
28. Walters CL, Brown S, Changeux JP, Martin B, Damaj MI. 2006. The beta2 but not alpha7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice. Psychopharmacology (Berl) 184: 339-344.
29. Ward JM, Cockcroft VB, Lunt GG, Smillie FS, Wonnacott S. 1990. Methyllycaconitine: a selective probe for neuronal alpha-bungarotoxin binding sites. FEBS Lett. 270: 45-48.
30. Welch KD, Green BT, Panter KE, Gardner DR, Pfister JA, Cook D, Stegelmeier BL. 2009. Investigation of the susceptibility of various strains of mice to methyllycaconitine toxicosis. J. Anim. Sci. 87: 1558-1564.
31. Welch KD, Panter KE, Gardner DR, Green BT, Pfister JA, Cook D, Stegelmeier BL. 2008. The effect of 7, 8-methylenedioxylycoctonine-type diterpenoid alkaloids on the toxicity of methyllycaconitine in mice. J. Anim. Sci. 86: 2761-2770.