Potentiation of the actions of acetylcholine, epibatidine, and nicotine by methyllycaconitine at fetal muscle-type nicotinic acetylcholine receptors

European Journal of Pharmacology

Volumn 662, Issue 1-3, 2011, Pages 15-21

  Green, Benedict T ^a   Welch, Kevin D ^a   Cook, Daniel ^a   Gardner, Dale R ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

Delphinium; Fetal muscle type nicotinic acetylcholine; Membrane potential; Methyllycaconitine; Neostigmine; receptors

Indexed keywords

ACETYLCHOLINE; EPIBATIDINE; METHYLLYCACONITINE; NEOSTIGMINE METHYL SULFATE; NICOTINE TARTRATE; NICOTINIC AGENT; NICOTINIC RECEPTOR;

ARTICLE; CANCER CELL CULTURE; CELL MEMBRANE POTENTIAL; CELL STRAIN TE 671; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; DRUG RECEPTOR BINDING; FETUS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHABDOMYOSARCOMA;

ACETYLCHOLINE; ACONITINE; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL LINE, TUMOR; CHOLINESTERASE INHIBITORS; DITERPENES; DRUG SYNERGISM; FETUS; HUMANS; LIGANDS; MEMBRANE POTENTIALS; MUSCLES; NEOSTIGMINE; NICOTINE; NICOTINIC AGONISTS; PYRIDINES; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79957614595     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.04.053     Document Type: Article

References (32)

1. Arias, H.R., 1997. Topology of ligand binding sites on the nicotinic acetylcholine receptor. Brain Res. Brain Res. Rev. 25, 133-191.
2. Arias, H.R., 2000. Localization of agonist and competitive antagonist binding sites on nicotinic acetylcholine receptors. Neurochem. Int. 36, 595-645.
3. Ascher, P., Large, W.A., Rang, H.P., 1979. Studies on the mechanism of action of acetylcholine antagonists on rat parasympathetic ganglion cells. J. Physiol. 295, 139-170. (Pubitemid 10248388)
4. Benn, M.H., Jacyno, J., 1983. The toxicology and pharmacology of diterpenoid alkaloids. In: Pelletier, S.W. (Ed.), Alkaloids: Chemical and Biological Perspectives. John Wiley & Sons, New York, NY, pp. 153-210.
5. Blount, P., Merlie, J.P., 1989. Molecular basis of the two nonequivalent ligand binding sites of the muscle nicotinic acetylcholine receptor. Neuron 3, 349-357.
6. Cachelin, A.B., Rust, G., 1994. Unusual pharmacology of (+)-tubocurarine with rat neuronal nicotinic acetylcholine receptors containing beta 4 subunits. Mol. Pharmacol. 46, 1168-1174.
7. Colquhoun, D., Dreyer, F., Sheridan, R.E., 1979. The actions of tubocurarine at the frog neuromuscular junction. J. Physiol. 293, 247-284. (Pubitemid 10233529)
8. Cooper, J.C., Gutbrod, O., Witzmann, V., Methfessel, C., 1996. Pharmacology of the nicotinic acetylcholine receptor from fetal rat muscle expressed in Xenopus oocytes. Eur. J. Pharmacol. 309, 287-289.
9. Green, B.T., Pfister, J.A., Cook, D., Welch, K.D., Stegelmeier, B.L., Lee, S.T., Gardner, D.R., Knoppel, E.L., Panter, K.E., 2009. Effects of larkspur (Delphinium barbeyi) on heart rate and electrically evoked electromyographic response of the external anal sphincter in cattle. Am. J. Vet. Res. 70, 539-546.
10. Green, B.T., Lee, S.T., Panter, K.E., Welch, K.D., Cook, D., Pfister, J.A., Kem, W.R., 2010. Actions of piperidine alkaloid teratogens at fetal nicotinic acetylcholine receptors. Neurotoxicol. Teratol. 32, 383-390.
11. Jo, Y.H., Talmage, D.A., Role, L.W., 2002. Nicotinic receptor-mediated effects on appetite and food intake. J. Neurobiol. 53, 618-632. (Pubitemid 35375591)
12. Kenakin, T.P., 2006. A Pharmacology Primer. Elsevier, New York, NY, pp. 87-88.
13. Lape, R., Krashia, P., Colquhoun, D., Sivilotti, L.G., 2009. Agonist and blocking actions of choline and tetramethylammonium on human muscle acetylcholine receptors. J. Physiol. 587, 5045-5072.
14. Lee, S.T.,Wildeboer, K., Panter, K.E., Kem, W.R., Gardner, D.R., Molyneux, R.J., Chang, C.W., Soti, F., Pfister, J.A., 2006. Relative toxicities and neuromuscular nicotinic receptor agonistic potencies of anabasine enantiomers and anabaseine. Neurotoxicol. Teratol. 28, 220-228.
15. Lee, S.T., Green, B.T., Welch, K.D., Pfister, J.A., Panter, K.E., 2008. Stereoselective potencies and relative toxicities of coniine enantiomers. Chem. Res. Toxicol. 21, 2061-2064.
16. Manners, G.D., Pfister, J.A., Ralphs, M.H., Panter, K.E., Olsen, J.D., 1991. Larkspur chemistry: toxic alkaloids in tall larkspurs. J. Range Manage 45, 63-67.
17. Manners, G.D., Panter, K.E., Ralphs, M.H., Pfister, J.A., Olsen, J.D., James, L.F., 1993. Toxicity and chemical phenology of norditerpenoid alkaloids in the tall larkspurs (Delphinium species). J. Agric. Food Chem. 41, 96-100.
18. Nagata, K., Huang, C.S., Song, J.H., Narahashi, T., 1997. Direct actions of anticholinesterases on the neuronal nicotinic acetylcholine receptor channels. Brain Res. 769, 211-218. (Pubitemid 27461454)
19. Pfister, J.A., Provenza, F.D., Manners, G.D., Gardner, D.R., Ralphs, M.H., 1997a. Tall larkspur ingestion: can cattle regulate intake below toxic levels? J. Chem. Ecol. 45, 759-777.
20. Pfister, J.A., Gardner, D.R., Price, K.W., 1997b. Grazing risk on tall larkspur-infested ranges. Rangelands 19, 12-15. (Pubitemid 127655060)
21. Prince, R.J., Sine, S.M., 1998. Epibatidine binds with unique site and state selectivity to muscle nicotinic acetylcholine receptors. J. Biol. Chem. 273, 7843-7849.
22. Sharples, C.G.V., Wonnacott, S., 2001. Neuronal nicotinic receptors. Tocris Rev., 19. Tocris Bioscience, Bristol, United Kingdom.
23. Sherby, S.M., Eldefrawi, A.T., Albuquerque, E.X., Eldefrawi, M.E., 1985. Comparison of the actions of carbamate anticholinesterases on the nicotinic acetylcholine receptor. Mol. Pharmacol. 27, 343-348.
24. Sine, S.M., 1988. Functional properties of human skeletal muscle acetylcholine receptors expressed by the TE671 cell line. J. Biol. Chem. 26, 18052-180623.
25. Smulders, C.J., Zwart, R., Bermudez, I., van Kleef, R.G., Groot-Kormelink, P.J., Vijverberg, H.P.M., 2005. Cholinergic drugs potentiate human nicotinic alpha4beta2 acetylcholine receptors by a competitive mechanism. Eur. J. Pharmacol. 509, 97-108.
26. Steinbach, J.H., Chen, Q., 1995. Antagonist and partial agonist actions of (d)-tubocurarine at mammalian muscle acetylcholine receptors. J. Neurosci. 15, 230-240.
27. Trautmann, A., 1982. Curare can open and block ionic channels associated with cholinergic receptors. Nature 298, 272-275. (Pubitemid 12089411)
28. Ward, J.M., Cockcroft, V.B., Lunt, G.G., Smillie, F.S., Wonnacott, S., 1990. Methyllycaconitine: a selective probe for neuronal alpha-bungarotoxin binding sites. FEBS Lett. 270, 45-48. (Pubitemid 20288565)
29. Ziskind, L., Dennis, M.J., 1978. Depolarizing effect of curare on embryonic rat muscles. Nature 276, 622-623. (Pubitemid 9087767)
30. Zwart, R., Vijverberg, H.P.M., 1997. Potentiation and inhibition of neuronal nicotinic receptors by atropine: competitive and noncompetitive effects. Mol. Pharmacol. 52, 886-895.
31. Zwart, R., Vijverberg, H.P.M., 2000. Potentiation and inhibition of neuronal alpha4beta4 nicotinic acetylcholine receptors by choline. Eur. J. Pharmacol. 393, 209-214.
32. Zwart, R., van Kleef, R.G., Gotti, C., Smulders, C.J., Vijverberg, H.P., 2000. Competitive potentiation of acetylcholine effects on neuronal nicotinic receptors by acetylcholinesterase-inhibiting drugs. J. Neurochem. 75, 2492-2500.