The influence of gender on the development of pulmonary arterial hypertension

Experimental Physiology

Volumn 98, Issue 8, 2013, Pages 1257-1261

  Dempsie, Yvonne ^a   Maclean, Margaret R ^b  

^a GLASGOW CALEDONIAN UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYESTRADIOL; 2 METHOXYESTRADIOL; ADVANCED GLYCATION END PRODUCT; CATECHOL METHYLTRANSFERASE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; ESTRADIOL; SEX HORMONE; TESTOSTERONE; TRYPTOPHAN HYDROXYLASE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL PROLIFERATION; DISEASE COURSE; ESTROGEN METABOLISM; GENDER BIAS; HEART FUNCTION; HEART RIGHT VENTRICLE FAILURE; HEART RIGHT VENTRICLE HYPERTROPHY; HUMAN; LUNG ARTERY PRESSURE; LUNG BLOOD VESSEL; LUNG PRESSURE; MORTALITY; NONHUMAN; PULMONARY HYPERTENSION; SEX DIFFERENCE; SMOOTH MUSCLE FIBER; SURVIVAL RATE; VASOCONSTRICTION;

EID: 84880697267     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2012.069120     Document Type: Article

References (30)

1. Austin ED, Cogan JD, West JD, Hedges LK, Hamid R, Dawson EP, Wheeler LA, Parl FF, Loyd JE & Phillips JA 3rd (2009). Alterations in oestrogen metabolism: implications for higher penetrance of familial pulmonary arterial hypertension in females. Eur Respir J 34, 1093-1099.
2. Badawi AF, Cavalieri EL & Rogan EG (2001). Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16α-hydroxylation of 17β-estradiol. Metabolism 50, 1001-1003.
3. Benza RL, Miller DP, Gomberg-Maitland M, Frantz RP, Foreman AJ, Coffey CS, Frost A, Barst RJ, Badesch DB, Elliott CG, Liou TG & McGoon MD (2010). Predicting survival in pulmonary arterial hypertension: insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL). Circulation 122, 164-172.
4. Dempsie Y & MacLean MR (2008). Pulmonary hypertension: therapeutic targets within the serotonin system. Br J Pharmacol 155, 455-462.
5. Dempsie Y, Macritchie NA, White K, Morecroft I, Wright AF, Nilsen M, Loughlin L, Mair KM & MacLean MR (2013). Dexfenfluramine and the oestrogen metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension. Cardiovasc Res doi: 10.1093/cvr/cvt064
6. Dempsie Y, Morecroft I, Welsh DJ, MacRitchie NA, Herold N, Loughlin L, Nilsen M, Peacock AJ, Harmar A, Bader M & MacLean MR (2008). Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice. Circulation 117, 2928-2937.
7. Dempsie Y, Nilsen M, White K, Mair KM, Loughlin L, Ambartsumian N, Rabinovitch M & MacLean MR (2011). Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females. Respir Res 12, 159.
8. Do e Z, Fukumoto Y, Takaki A, Tawara S, Ohashi J, Nakano M, Tada T, Saji K, Sugimura K, Fujita H, Hoshikawa Y, Nawata J, Kondo T & Shimokawa H (2009). Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension. Circ J 73, 1731-1739.
9. Eddahibi S, Guignabert C, Barlier-Mur AM, Dewachter L, Fadel E, Dartevelle P, Humbert M, Simonneau G, Hanoun N, Saurini F, Hamon M & Adnot S (2006). Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia. Circulation 113, 1857-1864.
10. Eddahibi S, Hanoun N, Lanfumey L, Lesch KP, Raffestin B, Hamon M & Adnot S (2000). Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene. J Clin Invest 105, 1555-1562.
11. Farhat MY, Chen MF, Bhatti T, Iqbal A, Cathapermal S & Ramwell PW (1993). Protection by oestradiol against the development of cardiovascular changes associated with monocrotaline pulmonary hypertension in rats. Br J Pharmacol 110, 719-723.
12. Hanna IH, Dawling S, Roodi N, Guengerich FP & Parl FF (2000). Cytochrome P450 1B1 (CYP1B1) pharmacogenetics: association of polymorphisms with functional differences in estrogen hydroxylation activity. Cancer Res 60, 3440-3444.
13. Hemnes AR, Maynard KB, Champion HC, Gleaves L, Penner N, West J & Newman JH (2012). Testosterone negatively regulates right ventricular load stress responses in mice. Pulm Circ 2, 352-358.
14. Hoeper MM, Huscher D, Ghofrani HA, Delcroix M, Distler O, Schweiger C, Grunig E, Staehler G, Rosenkranz S, Halank M, Held M, Grohé, C, Lange TJ, Behr J, Klose H, Wilkens H, Filusch A, Germann M, Ewert R, Seyfarth HJ, Olsson KM, Opitz CF, Gaine SP, Vizza CD, Vonk-Noordegraaf A, Kaemmerer H, Gibbs JS & Pittrow D. (2012). Elderly patients diagnosed with idiopathic pulmonary arterial hypertension: Results from the COMPERA registry. Int J Cardiol, doi:10.1016/j.ijcard.2012.10.026
15. Humbert M, Sitbon O, Chaouat A, Bertocchi M, Habib G, Gressin V, Yaici A, Weitzenblum E, Cordier JF, Chabot F, Dromer C, Pison C, Reynaud-Gaubert M, Haloun A, Laurent M, Hachulla E, Cottin V, Degano B, Jais X, Montani D, Souza R & Simonneau G (2010). Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation 122, 156-163.
16. Humbert M, Sitbon O, Chaouat A, Bertocchi M, Habib G, Gressin V, Yaici A, Weitzenblum E, Cordier JF, Chabot F, Dromer C, Pison C, Reynaud-Gaubert M, Haloun A, Laurent M, Hachulla E & Simonneau G (2006). Pulmonary arterial hypertension in France: results from a national registry. Am J Respir Crit Care Med 173, 1023-1030.
17. 1B/1D-receptor antagonist GR127935. Circ Res 89, 1231-1239.
18. Lahm T, Albrecht M, Fisher AJ, Selej M, Patel NG, Brown JA, Justice MJ, Brown MB, Van Demark M, Trulock KM, Dieudonne D, Reddy JG, Presson RG & Petrache I (2012). 17β-Estradiol attenuates hypoxic pulmonary hypertension via estrogen receptor-mediated effects. Am J Respir Crit Care Med 185, 965-980.
19. Lawrie A, Spiekerkoetter E, Martinez EC, Ambartsumian N, Sheward WJ, MacLean MR, Harmar AJ, Schmidt AM, Lukanidin E & Rabinovitch M (2005). Interdependent serotonin transporter and receptor pathways regulate S100A4/Mts1, a gene associated with pulmonary vascular disease. Circ Res 97, 227-235.
20. McMurtry IF, Frith CH & Will DH (1973). Cardiopulmonary responses of male and female swine to simulated high altitude. J Appl Physiol 35, 459-462.
21. Morecroft I, Dempsie Y, Bader M, Walther DJ, Kotnik K, Loughlin L, Nilsen M & MacLean MR (2007). Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension. Hypertension 49, 232-236.
22. 1B receptor/SERT antagonist in experimental pulmonary hypertension. Cardiovasc Res 85, 593-603.
23. Peacock AJ, Murphy NF, McMurray JJ, Caballero L & Stewart S (2007). An epidemiological study of pulmonary arterial hypertension. Eur Respir J 30, 104-109.
24. Rabinovitch M, Gamble WJ, Miettinen OS & Reid L (1981). Age and sex influence on pulmonary hypertension of chronic hypoxia and on recovery. Am J Physiol Heart Circ Physiol 240, H62-H72.
25. Rothman RB, Ayestas MA, Dersch CM & Baumann MH (1999). Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. Circulation 100, 869-875.
26. Tofovic SP, Zhang XC, Jackson EK, Dacic S & Petrusevska G (2006). 2-Methoxyestradiol mediates the protective effects of estradiol in monocrotaline-induced pulmonary hypertension. Vascul Pharmacol 45, 358-367.
27. Ventetuolo CE, Ouyang P, Bluemke DA, Tandri H, Barr RG, Bagiella E, Cappola AR, Bristow MR, Johnson C, Kronmal RA, Kizer JR, Lima JA & Kawut SM (2011). Sex hormones are associated with right ventricular structure and function: the MESA-right ventricle study. Am J Respir Crit Care Med 183, 659-667.
28. White K, Dempsie Y, Nilsen M, Wright AF, Loughlin L & MacLean MR (2011a). The serotonin transporter, gender, and 17β oestradiol in the development of pulmonary arterial hypertension. Cardiovasc Res 90, 373-382.
29. White K, Johansen AK, Nilsen M, Ciuclan L, Wallace E, Paton L, Campbell A, Morecroft I, Loughlin L, McClure JD, Thomas M, Mair KM & MacLean MR (2012). Activity of the estrogen-metabolizing enzyme cytochrome P450 1B1 influences the development of pulmonary arterial hypertension. Circulation 28, 1087-1098.
30. White K, Loughlin L, Maqbool Z, Nilsen M, McClure J, Dempsie Y, Baker AH & MacLean MR (2011b). Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH. Physiol Genomics 43, 417-437.