Functional genomic screen of human stem cell differentiation reveals pathways involved in neurodevelopment and neurodegeneration

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 30, 2013, Pages 12361-12366

  Zhang, Ying ^a   Schulz, Vincent P ^a   Reed, Brian D ^a   Wang, Zheng ^a   Pan, Xinghua ^a   Mariani, Jessica ^a,b   Euskirchen, Ghia ^c   Snyder, Michael P ^c   Vaccarino, Flora M ^a,b   Ivanova, Natalia ^a   Weissman, Sherman M ^a   Szekely, Anna M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

High throughput sequencing; Mendelian disorders of the nervous system; Neural differentiation; Pooled RNAi screening; RNA binding proteins

Indexed keywords

SHORT HAIRPIN RNA;

ARTICLE; CELL DIFFERENTIATION; CELL RENEWAL; CELL SURVIVAL; CONTROLLED STUDY; DEGENERATIVE DISEASE; EMBRYONIC STEM CELL; FEASIBILITY STUDY; FUNCTIONAL GENOMICS; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; GENETIC SCREENING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; NERVE CELL DIFFERENTIATION; NERVE DEGENERATION; NEURAL STEM CELL; PLURIPOTENT STEM CELL; PRIORITY JOURNAL;

HIGH-THROUGHPUT SEQUENCING; MENDELIAN DISORDERS OF THE NERVOUS SYSTEM; NEURAL DIFFERENTIATION; POOLED RNAI SCREENING; RNA-BINDING PROTEINS;

AUTISTIC DISORDER; CELL DIFFERENTIATION; GENE SILENCING; GENE TARGETING; GENOME, HUMAN; HUMANS; INTELLECTUAL DISABILITY; NEURONS; RNA; STEM CELLS;

EID: 84880682069     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1309725110     Document Type: Article

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