메뉴 건너뛰기




Volumn 42, Issue 6, 2013, Pages 1016-1026

Integrated genomic, transcriptomic, and RNA-interference analysis of genes in somatic copy number gains in pancreatic ductal adenocarcinoma

Author keywords

driver gene; ECT2; pancreatic cancer; RNA interference; somatic copy number gain

Indexed keywords

K RAS PROTEIN; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR GATA 6;

EID: 84880677913     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0b013e318287d043     Document Type: Article
Times cited : (6)

References (35)
  • 3
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
    • Burris HA 3rd, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol. 1997;15:2403-2413.
    • (1997) J Clin Oncol. , vol.15 , pp. 2403-2413
    • Burris III, H.A.1    Moore, M.J.2    Andersen, J.3
  • 4
    • 33646577163 scopus 로고    scopus 로고
    • Genetics and biology of pancreatic ductal adenocarcinoma
    • Hezel AF, Kimmelman AC, Stanger BZ, et al. Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev. 2006;20(10): 1218-1249.
    • (2006) Genes Dev. , vol.20 , Issue.10 , pp. 1218-1249
    • Hezel, A.F.1    Kimmelman, A.C.2    Stanger, B.Z.3
  • 5
    • 41149161849 scopus 로고    scopus 로고
    • Molecular genetics of pancreatic ductal adenocarcinomas and recent implications for translational efforts
    • Feldmann G, Maitra A. Molecular genetics of pancreatic ductal adenocarcinomas and recent implications for translational efforts. J Mol Diagn. 2008;10(2):111-122.
    • (2008) J Mol Diagn. , vol.10 , Issue.2 , pp. 111-122
    • Feldmann, G.1    Maitra, A.2
  • 7
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646-674.
    • (2011) Cell. , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 8
    • 57449108348 scopus 로고    scopus 로고
    • Genome-wide analysis of pancreatic cancer using microarray-based techniques
    • Harada T, Chelala C, Crnogorac-Jurcevic T, et al. Genome-wide analysis of pancreatic cancer using microarray-based techniques. Pancreatology. 2009;9(1-2):13-24.
    • (2009) Pancreatology. , vol.9 , Issue.1-2 , pp. 13-24
    • Harada, T.1    Chelala, C.2    Crnogorac-Jurcevic, T.3
  • 9
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S, Zhang X, Parsons DW, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008;321:1801-1806.
    • (2008) Science. , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3
  • 10
    • 54349103007 scopus 로고    scopus 로고
    • Frequent genomic copy number gain and overexpression of GATA-6 in pancreatic carcinoma
    • Fu B, Luo M, Lakkur S, et al. Frequent genomic copy number gain and overexpression of GATA-6 in pancreatic carcinoma. Cancer Biol Ther. 2008;7(10):1593-1601.
    • (2008) Cancer Biol Ther. , vol.7 , Issue.10 , pp. 1593-1601
    • Fu, B.1    Luo, M.2    Lakkur, S.3
  • 11
    • 58049221106 scopus 로고    scopus 로고
    • Genomic alterations link Rho family GTPases to the highly invasive phenotype of pancreas cancer
    • Kimmelman AC, Hezel AF, Aguirre AJ, et al. Genomic alterations link Rho family GTPases to the highly invasive phenotype of pancreas cancer. Proc Natl Acad Sci USA. 2008;105(49):19372-19377.
    • (2008) Proc Natl Acad Sci USA. , vol.105 , Issue.49 , pp. 19372-19377
    • Kimmelman, A.C.1    Hezel, A.F.2    Aguirre, A.J.3
  • 12
    • 38949218379 scopus 로고    scopus 로고
    • Genomic imbalances in 5918 malignant epithelial tumors: An explorative meta-analysis of chromosomal CGH data
    • Baudis M. Genomic imbalances in 5918 malignant epithelial tumors: an explorative meta-analysis of chromosomal CGH data. BMC Cancer. 2007;18:7-226.
    • (2007) BMC Cancer. , vol.18 , pp. 7-226
    • Baudis, M.1
  • 13
    • 84856955522 scopus 로고    scopus 로고
    • The molecular and cellular heterogeneity of pancreatic ductal adenocarcinoma
    • Samuel N, Hudson TJ. The molecular and cellular heterogeneity of pancreatic ductal adenocarcinoma. Nat Rev Gastroenterol Hepatol. 2011;9(2):77-87.
    • (2011) Nat Rev Gastroenterol Hepatol. , vol.9 , Issue.2 , pp. 77-87
    • Samuel, N.1    Hudson, T.J.2
  • 14
    • 20044375763 scopus 로고    scopus 로고
    • Array comparative genomic hybridization and its applications in cancer
    • Pinkel D, Albertson DG. Array comparative genomic hybridization and its applications in cancer. Nature Genetics. 2005;37:S11-S17.
    • (2005) Nature Genetics. , vol.37
    • Pinkel, D.1    Albertson, D.G.2
  • 15
    • 33646033137 scopus 로고    scopus 로고
    • A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
    • Moffat J, Gruenberg DA, Yang X, et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell. 2006;124(6):1283-1298.
    • (2006) Cell. , vol.124 , Issue.6 , pp. 1283-1298
    • Moffat, J.1    Gruenberg, D.A.2    Yang, X.3
  • 16
    • 84865202966 scopus 로고    scopus 로고
    • Essential gene profiles in breast, pancreas and ovarian cancer cells
    • Marcotte R, Brown KR, Suarez F, et al. Essential gene profiles in breast, pancreas and ovarian cancer cells. Cancer Discovery. 2012; 2(2):172-189.
    • (2012) Cancer Discovery. , vol.2 , Issue.2 , pp. 172-189
    • Marcotte, R.1    Brown, K.R.2    Suarez, F.3
  • 18
    • 3543105225 scopus 로고    scopus 로고
    • Circular binary segmentation for the analysis of array-based DNA copy number data
    • Olshen AB, Venkatraman ES, Lucito R, et al. Circular binary segmentation for the analysis of array-based DNA copy number data. Biostatistics. 2004;5(4):557-572.
    • (2004) Biostatistics. , vol.5 , Issue.4 , pp. 557-572
    • Olshen, A.B.1    Venkatraman, E.S.2    Lucito, R.3
  • 19
    • 79960268207 scopus 로고    scopus 로고
    • GPHMM: An integrated hidden Markov model for identification of copy number alteration and loss of heterozygosity in complex tumor samples using whole genome SNP arrays
    • Li A, Liu Z, Lezdon-Geyda K, et al. GPHMM: an integrated hidden Markov model for identification of copy number alteration and loss of heterozygosity in complex tumor samples using whole genome SNP arrays. Nucleic Acids Res. 2011;39(12):4928-4941.
    • (2011) Nucleic Acids Res. , vol.39 , Issue.12 , pp. 4928-4941
    • Li, A.1    Liu, Z.2    Lezdon-Geyda, K.3
  • 20
    • 39149111937 scopus 로고    scopus 로고
    • Model-based variance-stabilizing transformation for Illumina microarray data
    • Lin SM, Du P, Huber W, et al. Model-based variance-stabilizing transformation for Illumina microarray data. Nucleic Acids Res. 2008; 36(2):e11.
    • (2008) Nucleic Acids Res. , vol.36 , Issue.2
    • Lin, S.M.1    Du, P.2    Huber, W.3
  • 21
    • 79958162661 scopus 로고    scopus 로고
    • Comprehensive assessment of array-based platforms and calling algorithms for detection of copy number variants
    • Pinto D, Darvishi K, Shi X, et al. Comprehensive assessment of array-based platforms and calling algorithms for detection of copy number variants. Nat Biotechnol. 2011;29(6):512-520.
    • (2011) Nat Biotechnol. , vol.29 , Issue.6 , pp. 512-520
    • Pinto, D.1    Darvishi, K.2    Shi, X.3
  • 22
    • 0036262452 scopus 로고    scopus 로고
    • Detailed genomic mapping and expression analysis of 12p amplifications in pancreatic carcinomas reveal a 3.5-Mb target region for amplification
    • Heidenblad M, Jonson T, Mahlamaki EH, et al. Detailed genomic mapping and expression analysis of 12p amplifications in pancreatic carcinomas reveal a 3.5-Mb target region for amplification. Genes Chromosomes Cancer. 2002;34(2):211-223.
    • (2002) Genes Chromosomes Cancer. , vol.34 , Issue.2 , pp. 211-223
    • Heidenblad, M.1    Jonson, T.2    Mahlamaki, E.H.3
  • 23
    • 77249119762 scopus 로고    scopus 로고
    • The landscape of somatic copy-number alterations across human cancers
    • Beroukhim R, Mermel CH, Porter D, et al. The landscape of somatic copy-number alterations across human cancers. Nature. 2010; 463:899-905.
    • (2010) Nature. , vol.463 , pp. 899-905
    • Beroukhim, R.1    Mermel, C.H.2    Porter, D.3
  • 24
    • 79955921754 scopus 로고    scopus 로고
    • FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
    • Conroy T, Desseigne F, Ychou M, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011; 364(19):1817-1825.
    • (2011) N Engl J Med. , vol.364 , Issue.19 , pp. 1817-1825
    • Conroy, T.1    Desseigne, F.2    Ychou, M.3
  • 25
    • 0033779252 scopus 로고    scopus 로고
    • Biological rationale for HER2/neu (c-erbB2) as a target for monoclonal antibody therapy
    • Pegram M, Slamon D. Biological rationale for HER2/neu (c-erbB2) as a target for monoclonal antibody therapy. Semin Oncol. 2000;27(9):13-19.
    • (2000) Semin Oncol. , vol.27 , Issue.9 , pp. 13-19
    • Pegram, M.1    Slamon, D.2
  • 26
    • 46949102023 scopus 로고    scopus 로고
    • Transmembrane protein 85 from both human (TMEM85) and yeast (YGL231c) inhibit hydrogen peroxide mediated cell death in yeast
    • Ring G, Khoury CM, Solar AJ, et al. Transmembrane protein 85 from both human (TMEM85) and yeast (YGL231c) inhibit hydrogen peroxide mediated cell death in yeast. FEBS Lett. 2008; 582(17):2637-2642.
    • (2008) FEBS Lett. , vol.582 , Issue.17 , pp. 2637-2642
    • Ring, G.1    Khoury, C.M.2    Solar, A.J.3
  • 27
    • 27644554700 scopus 로고    scopus 로고
    • A heterodimeric complex that promotes assembly of mammalian 20S proteasome
    • Hirano Y, Hendil KB, Yashiroda H, et al. A heterodimeric complex that promotes assembly of mammalian 20S proteasome. Nature. 2005; 437(7063):1381-1385.
    • (2005) Nature. , vol.437 , Issue.7063 , pp. 1381-1385
    • Hirano, Y.1    Hendil, K.B.2    Yashiroda, H.3
  • 28
    • 57149120776 scopus 로고    scopus 로고
    • The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma
    • Salhia B, Tran NL, Chan A, et al. The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma. Am J Pathol. 2008;173(6):1828-1838.
    • (2008) Am J Pathol. , vol.173 , Issue.6 , pp. 1828-1838
    • Salhia, B.1    Tran, N.L.2    Chan, A.3
  • 29
    • 35848937194 scopus 로고    scopus 로고
    • Expression level of ECT2 proto-oncogene correlates with prognosis in glioma patients
    • Sano M, Genkai N, Yajima N, et al. Expression level of ECT2 proto-oncogene correlates with prognosis in glioma patients. Oncol Rep. 2006;16(5):1093-1098.
    • (2006) Oncol Rep. , vol.16 , Issue.5 , pp. 1093-1098
    • Sano, M.1    Genkai, N.2    Yajima, N.3
  • 30
    • 58949091881 scopus 로고    scopus 로고
    • Involvement of epithelial cell transforming sequence-2 oncoantigen in lung and esophageal cancer progression
    • Hirata D, Yamabuki T, Miki D, et al. Involvement of epithelial cell transforming sequence-2 oncoantigen in lung and esophageal cancer progression. Clin Cancer Res. 2009;15(1):256-266.
    • (2009) Clin Cancer Res. , vol.15 , Issue.1 , pp. 256-266
    • Hirata, D.1    Yamabuki, T.2    Miki, D.3
  • 31
    • 70350074501 scopus 로고    scopus 로고
    • Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation
    • Justilien V, Fields AP. Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation. Oncogene. 2009; 28(41):3597-3607.
    • (2009) Oncogene. , vol.28 , Issue.41 , pp. 3597-3607
    • Justilien, V.1    Fields, A.P.2
  • 32
    • 78649760558 scopus 로고    scopus 로고
    • Epithelial cell transforming sequence 2 in human oral cancer
    • Iyoda M, Kasamatsu A, Ishigami T, et al. Epithelial cell transforming sequence 2 in human oral cancer. PLoS One. 2010;5(11):e14082.
    • (2010) PLoS One. , vol.5 , Issue.11
    • Iyoda, M.1    Kasamatsu, A.2    Ishigami, T.3
  • 33
    • 67949106468 scopus 로고    scopus 로고
    • High-resolution analysis of copy number alterations and associated expression changes in ovarian tumors
    • Haverty PM, Hon LS, Kaminker JS, et al. High-resolution analysis of copy number alterations and associated expression changes in ovarian tumors. BMC Med Genomics. 2009;2:21.
    • (2009) BMC Med Genomics. , vol.2 , pp. 21
    • Haverty, P.M.1    Hon, L.S.2    Kaminker, J.S.3
  • 34
    • 78651108985 scopus 로고    scopus 로고
    • Pancreatic cancer: Understanding and overcoming chemoresistance
    • Wang Z, Li Y, Ahmad A, et al. Pancreatic cancer: understanding and overcoming chemoresistance. Nat Rev Gastroenterol Hepatol. 2011;8:27-33.
    • (2011) Nat Rev Gastroenterol Hepatol. , vol.8 , pp. 27-33
    • Wang, Z.1    Li, Y.2    Ahmad, A.3
  • 35
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger M, Rowan AJ, Horswell S, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med. 2012;366(10):883-892.
    • (2012) N Engl J Med. , vol.366 , Issue.10 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.