Efficient initiation of dna replication in eukaryotes requires dpb11/topbp1-gins interaction

Molecular and Cellular Biology

Volumn 33, Issue 13, 2013, Pages 2614-2622

  Tanaka, Seiji ^a,b   Komeda, Yayoi ^a   Umemori, Toshiko ^a   Kubota, Yumiko ^c   Takisawa, Haruhiko ^c   Araki, Hiroyuki ^a,b  

^a NATIONAL INSTITUTE OF GENETICS   (Japan)

^b GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CYCLIN DEPENDENT KINASE;

ARTICLE; BRCT1 DOMAIN; BRCT2 DOMAIN; BRCT3 DOMAIN; BRCT4 DOMAIN; CELL GROWTH; DNA REPLICATION; EUKARYOTE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SACCHAROMYCES CEREVISIAE;

AMINO ACID SUBSTITUTION; ANIMALS; CARRIER PROTEINS; CELL CYCLE PROTEINS; DNA REPLICATION; MULTIPROTEIN COMPLEXES; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84880662044     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00431-13     Document Type: Article

References (34)

1. Tanaka S, Araki H. 2010. Regulation of the initiation step of DNA replication by cyclin-dependent kinases. Chromosoma 119:565-574.
2. Labib K. 2010. How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells? Genes Dev. 24: 1208-1219.
3. Masumoto H, Muramatsu S, Kamimura Y, Araki H. 2002. S-Cdkdependent phosphorylation of Sld2 essential for chromosomal DNA eplication in budding yeast. Nature 415:651-655.
4. Tak YS, Tanaka Y, Endo S, Kamimura Y, Araki H. 2006. A CDKcatalysed regulatory phosphorylation for formation of the DNA replication complex Sld2-Dpb11. EMBO J. 25:1987-1996.
5. Zegerman P, Diffley JF. 2007. Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 445:281-285.
6. Tanaka S, Umemori T, Hirai K, Muramatsu S, Kamimura Y, Araki H. 2007. CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature 445:328-332.
7. Gambus A, Jones RC, Sanchez-Diaz A, Kanemaki M, van Deursen F, Edmondson RD, Labib K. 2006. GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat. Cell Biol. 8:358-366.
8. Moyer SE, Lewis PW, Botchan MR. 2006. Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Proc. Natl. Acad. Sci. U. S. A. 103:10236-10241.
9. Muramatsu S, Hirai K, Tak YS, Kamimura Y, Araki H. 2010. CDKdependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon), and GINS in budding yeast. Genes Dev. 24:602-612.
10. Garcia V, Furuya K, Carr AM. 2005. Identification and functional analysis of TopBP1 and its homologs. DNA Repair (Amst) 4:1227-1239.
11. Tanaka S, Tak YS, Araki H. 2007. The role of CDK in the initiation step of DNA replication in eukaryotes. Cell Div. 2:16. doi:10.1186/1747-1028-2-16.
12. Saka Y, Fantes P, Sutani T, McInerny C, Creanor J, Yanagida M. 1994. Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control. EMBO J. 13:5319-5329.
13. Araki H, Leem SH, Phongdara A, Sugino A. 1995. Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint. Proc. Natl. Acad. Sci. U. S. A. 92:11791-11795.
14. Mäkiniemi M, Hillukkala T, Tuusa J, Reini K, Vaara M, Huang D, Pospiech H, Majuri I, Westerling T, Makela TP, Syvaoja JE. 2001. BRCT domain-containing protein TopBP1 functions in DNA replication and damage response. J. Biol. Chem. 276:30399-30406.
15. Kumagai A, Shevchenko A, Dunphy WG. 2011. Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication. J. Cell Biol. 193:995-1007.
16. Boos D, Sanchez-Pulido L, Rappas M, Pearl LH, Oliver AW, Ponting CP, Diffley JF. 2011. Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans. Curr. Biol. 21:1152-1157.
17. Rappas M, Oliver AW, Pearl LH. 2011. Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1. Nucleic Acids Res. 39:313-324.
18. Van Hatten RA, Tutter AV, Holway AH, Khederian AM, Walter JC, Michael WM. 2002. The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication. J. Cell Biol. 159:541-547.
19. Hashimoto Y, Takisawa H. 2003. Xenopus Cut5 is essential for a CDKdependent process in the initiation of DNA replication. EMBO J. 22: 2526-2535.
20. Kumagai A, Shevchenko A, Dunphy WG. 2010. Treslin collaborates with TopBP1 in triggering the initiation ofDNAreplication. Cell 140:349-359.
21. Matsuno K, Kumano M, Kubota Y, Hashimoto Y, Takisawa H. 2006. The N-terminal noncatalytic region of Xenopus RecQ4 is required for chromatin binding of DNA polymerase alpha in the initiation of DNA replication. Mol. Cell. Biol. 26:4843-4852.
22. Sangrithi MN, Bernal JA, Madine M, Philpott A, Lee J, Dunphy WG, Venkitaraman AR. 2005. Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome. Cell 121: 887-898.
23. Kubota Y, Takase Y, Komori Y, Hashimoto Y, Arata T, Kamimura Y, Araki H, Takisawa H. 2003. A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replication. Genes Dev. 17:1141-1152.
24. Takayama Y, Kamimura Y, Okawa M, Muramatsu S, Sugino A, Araki H. 2003. GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast. Genes Dev. 17:1153-1165.
25. Tanaka S, Araki H. 2011. Multiple regulatory mechanisms to inhibit untimely initiation of DNA replication are important for stable genome maintenance. PLoS Genet. 7:e1002136. doi:10.1371/journal.pgen.1002136.
26. Tanaka S, Diffley JF. 2002. Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase. Nat. Cell Biol. 4:198-207.
27. Tanaka S, Nakato R, Katou Y, Shirahige K, Araki H. 2011. Origin association of sld3, sld7, and cdc45 proteins is a key step for determination of origin-firing timing. Curr. Biol. 21:2055-2063.
28. Liang C, Stillman B. 1997. Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants. Genes Dev. 11:3375-3386.
29. Bartel PL, Fields S. 1995. Analyzing protein-protein interactions using two-hybrid system. Methods Enzymol. 254:241-263.
30. Hashimoto Y, Tsujimura T, Sugino A, Takisawa H. 2006. The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATRdependent activation of Chk1. Genes Cells 11:993-1007.
31. Kamimura Y, Tak YS, Sugino A, Araki H. 2001. Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae. EMBO J. 20:2097-2107.
32. Tanaka T, Umemori T, Endo S, Muramatsu S, Kanemaki M, Kamimura Y, Obuse C, Araki H. 2011. Sld7, an Sld3-associated protein required for efficient chromosomal DNA replication in budding yeast. EMBO J. 30: 2019-2030.
33. Nakajima R, Masukata H. 2002. SpSld3 is required for loading and maintenance of SpCdc45 on chromatin in DNA replication in fission yeast. Mol. Biol. Cell 13:1462-1472.
34. Fukuura M, Nagao K, Obuse C, Takahashi TS, Nakagawa T, Masukata H. 2011. CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast. Mol. Biol. Cell 22:2620-2633.