A mechanism of gap junction docking revealed by functional rescue of a human-disease-linked connexin mutant

Journal of Cell Science

Volumn 126, Issue 14, 2013, Pages 3113-3120

  Gong, Xiang Qun ^a   Nakagawa, So ^b   Tsukihara, Tomitake ^b   Bai, Donglin ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Docking; Dual whole cell patch clamp; Gap junction channel; Homology modelling; Hydrogen bond

Indexed keywords

CONNEXIN 26; CONNEXIN 32;

ARTICLE; CHANNEL GATING; CONTROLLED STUDY; CRYSTAL STRUCTURE; FEMALE; GAP JUNCTION; GENE MUTATION; HUMAN; HUMAN CELL; HYDROGEN BOND; MOLECULAR DOCKING; MORPHOLOGY; MUTANT; PRIORITY JOURNAL; SEQUENCE ALIGNMENT;

DOCKING; DUAL WHOLE CELL PATCH-CLAMP; GAP JUNCTION CHANNEL; HOMOLOGY MODELLING; HYDROGEN BOND;

ANIMALS; CHANNELOPATHIES; CONNEXINS; GAP JUNCTIONS; GENETIC ENGINEERING; HELA CELLS; HUMANS; HYDROGEN BONDING; ION CHANNELS; MICE; MODELS, CHEMICAL; MOLECULAR TARGETED THERAPY; MUTATION; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; SEQUENCE ALIGNMENT; SOFTWARE;

EID: 84880659346     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.123430     Document Type: Article

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