Effects of caffeine on the inflammatory response induced by a 15-km run competition

Medicine and Science in Sports and Exercise

Volumn 45, Issue 7, 2013, Pages 1269-1276

  Tauler, Pedro ^a   Martínez, Sonia ^a   Moreno, Carlos ^a   Monjo, Marta ^a   Martínez, Pau ^a   Aguiló, Antoni ^a  

^a UNIVERSITAT DE LES ILLES BALEARS   (Spain)

Author keywords

adrenaline; caffeine; IL 10; IL 6; lactate; oxidative stress

Indexed keywords

ADRENALIN; BIOLOGICAL MARKER; CAFFEINE; CENTRAL STIMULANT AGENT; INTERLEUKIN 10; INTERLEUKIN 6;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BLOOD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INFLAMMATION; LEUKOCYTE COUNT; MALE; NORMAL HUMAN; OXIDATIVE STRESS; PHYSIOLOGY; RUNNING;

ADULT; ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; CAFFEINE; CENTRAL NERVOUS SYSTEM STIMULANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; EPINEPHRINE; HEALTHY VOLUNTEERS; HUMANS; INFLAMMATION; INTERLEUKIN-10; INTERLEUKIN-6; LEUKOCYTE COUNT; MALE; OXIDATIVE STRESS; RUNNING;

EID: 84880637926     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e3182857c8a     Document Type: Article

References (40)

1. Agarwal R, Chase SD. Rapid, fluorimetric-liquid chromatographic determination of malondialdehyde in biological samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2002;775(1):121-6.
2. Akira S, Taga T, Kishimoto T. Interleukin-6 in biology and medicine. Adv Immunol. 1993;54:1-78.
3. Baez S, Segura-Aguilar J, Widersten M, Johansson AS, Mannervik B. Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes. Biochem J. 1997;324(Pt 1):25-8.
4. Bishop NC, Fitzgerald C, Porter PJ, Scanlon GA, Smith AC. Effect of caffeine ingestion on lymphocyte counts and subset activation in vivo following strenuous cycling. Eur J Appl Physiol. 2005;93(5-6):606-13.
5. Blanchard J, Mohammadi JD, Conrad KA. Improved liquidchromatographic determination of caffeine in plasma. Clin Chem. 1980;26(9):1351-4.
6. Buxton DB, Fisher RA, Robertson SM, Olson MS. Stimulation of glycogenolysis and vasoconstriction by adenosine and adenosine analogues in the perfused rat liver. Biochem J. 1987;248(1):35-41.
7. Dill DB, Costill DL. Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol. 1974;37(2):247-8.
8. Doherty M, Smith PM. Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis. Scand J Med Sci Sports. 2005;15(2):69-78.
9. Eigler A, Siegmund B, Emmerich U, Baumann KH, Hartmann G, Endres S. Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production. J Leukoc Biol. 1998;63(1):101-7.
10. Febbraio MA, Ott P, Nielsen HB, et al. Hepatosplanchnic clearance of interleukin-6 in humans during exercise. Am J Physiol Endocrinol Metab. 2003;285(2):E397-402.
11. Fischer CP, Hiscock NJ, Penkowa M, et al. Supplementation with vitamins C and E inhibits the release of interleukin-6 from contracting human skeletal muscle. J Physiol. 2004;558(Pt 2):633-45.
12. Gay CA, Gebicki JM. Perchloric acid enhances sensitivity and reproducibility of the ferric-xylenol orange peroxide assay. Anal Biochem. 2002;304(1):42-6.
13. Graham TE. Caffeine and exercise: metabolism, endurance and performance. Sports Med. 2001;31(11):785-807.
14. Groussard C, Morel I, Chevanne M, Monnier M, Cillard J, Delamarche A. Free radical scavenging and antioxidant effects of lactate ion: an in vitro study. J Appl Physiol. 2000;89(1):169-75.
15. Hamann JJ, Kelley KM, Gladden LB. Effect of epinephrine on net lactate uptake by contracting skeletal muscle. J Appl Physiol. 2001;91(6):2635-41.
16. Hasko G, Cronstein BN. Adenosine: an endogenous regulator of innate immunity. Trends Immunol. 2004;25(1):33-9.
17. Horrigan LA, Kelly JP, Connor TJ. Immunomodulatory effects of caffeine: friend or foe? Pharmacol Ther. 2006;111(3): 877-92.
18. Hulston CJ, Jeukendrup AE. Substrate metabolism and exercise performance with caffeine and carbohydrate intake. Med Sci Sports Exerc. 2008;40(12):2096-104.
19. Lovlin R, Cottle W, Pyke I, Kavanagh M, Belcastro AN. Are indices of free radical damage related to exercise intensity. Eur J Appl Physiol Occup Physiol. 1987;56(3):313-6.
20. Nielsen HB, Febbraio MA, Ott P, Krustrup P, Secher NH. Hepatic lactate uptake versus leg lactate output during exercise in humans. J Appl Physiol. 2007;103(4):1227-33.
21. Olcina GJ, Munoz D, Timon R, et al. Effect of caffeine on oxidative stress during maximum incremental exercise. J Sports Sci Med. 2006;5:621-8.
22. Olcina GJ, Timon R, Munoz D, Maynar JI, Caballero MJ, Maynar M. Caffeine ingestion effects on oxidative stress in a steady-state test at 75%VO2max. Science & Sports. 2008;23:87-90.
23. Ostrowski K, Rohde T, Asp S, Schjerling P, Pedersen BK. Proand anti-inflammatory cytokine balance in strenuous exercise in humans. J Physiol. 1999;515(Pt 1):287-91.
24. Peake JM, Suzuki K, Coombes JS. The influence of antioxidant supplementation on markers of inflammation and the relationship to oxidative stress after exercise. J Nutr Biochem. 2007;18(6):357-71.
25. Pedersen BK, Febbraio MA. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev. 2008;88(4): 1379-406.
26. Pedersen BK, Hoffman-Goetz L. Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev. 2000;80(3): 1055-81.
27. Pedersen BK, Steensberg A, Fischer C, et al. The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor? Proc Nutr Soc. 2004;63(2):263-7.
28. Pedersen BK, Steensberg A, Keller P, et al. Muscle-derived interleukin-6: lipolytic, anti-inflammatory and immune regulatory effects. Pflugers Arch. 2003;446(1):9-16.
29. Steensberg A, Fischer CP, Keller C, Moller K, Pedersen BK. IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Endocrinol Metab. 2003;285(2):E433-7.
30. Steensberg A, Toft AD, Schjerling P, Halkjaer-Kristensen J, Pedersen BK. Plasma interleukin-6 during strenuous exercise: role of epinephrine. Am J Physiol Cell Physiol. 2001;281(3):C1001-4.
31. Steensberg A, van Hall G, Osada T, Sacchetti M, Saltin B, Klarlund Pedersen B. Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J Physiol. 2000;529(Pt 1):237-42.
32. Takala J. Determinants of splanchnic blood flow. Br J Anaesth. 1996;77(1):50-8.
33. Tauler P, Ferrer MD, Romaguera D, et al. Antioxidant response and oxidative damage induced by a swimming session: influence of gender. J Sports Sci. 2008;26(12):1303-11.
34. Vergauwen L, Hespel P, Richter EA. Adenosine receptors mediate synergistic stimulation of glucose uptake and transport by insulin and by contractions in rat skeletal muscle. J Clin Invest. 1994; 93(3):974-81.
35. Vistisen K, Poulsen HE, Loft S. Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine. Carcinogenesis. 1992;13(9):1561-8.
36. Walker GJ, Caudwell P, Dixon N, Bishop NC. The effect of caffeine ingestion on neutrophil oxidative burst responses following prolonged cycling. Int J Sport Nutr Exerc Metab. 2006;16(1):24-35.
37. Walker GJ, Dziubak A, Houghton L, Prendergast C, Lim L, Bishop NC. The effect of caffeine ingestion on human neutrophil oxidative burst responses following time-trial cycling. J Sports Sci. 2008;26(6):611-9.
38. Walker GJ, Finlay O, Griffiths H, Sylvester J, Williams M, Bishop NC. Immunoendocrine response to cycling following ingestion of caffeine and carbohydrate. Med Sci Sports Exerc. 2007;39(9):1554-60.
39. Watt MJ, Howlett KF, Febbraio MA, Spriet LL, Hargreaves M. Adrenaline increases skeletal muscle glycogenolysis, pyruvate dehydrogenase activation and carbohydrate oxidation during moderate exercise in humans. J Physiol. 2001;534(Pt 1):269-78.
40. Yamada M, Suzuki K, Kudo S, Totsuka M, Nakaji S, Sugawara K. Raised plasma G-CSF and IL-6 after exercise may play a role in neutrophil mobilization into the circulation. J Appl Physiol. 2002; 92(5):1789-94.