Hydantoin based inhibitors of MMP13 - Discovery of AZD6605

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 16, 2013, Pages 4705-4712

  De Savi, Chris ^a,b   Waterson, David ^b   Pape, Andrew ^b   Lamont, Scott ^b   Hadley, Elma ^b   Mills, Mark ^b   Page, Ken M ^b   Bowyer, Jonathan ^b   Maciewicz, Rose A ^b  

^a ASTRAZENECA   (United Kingdom)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Cyp P450; Hydantoin; Lead optimisation; MMP13; Zinc binder

Indexed keywords

AZD 6605; COLLAGENASE 3; COLLAGENASE INHIBITOR; HYDANTOIN; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 16; STROMELYSIN; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DOG; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG POTENCY; DRUG SAFETY; DRUG SOLUBILITY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MITSUNOBU REACTION; NONHUMAN; RAT;

CYP P450; HYDANTOIN; LEAD OPTIMISATION; MMP13; ZINC BINDER;

ANIMALS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DOGS; DRUG DISCOVERY; ENZYME ACTIVATION; HYDANTOINS; INHIBITORY CONCENTRATION 50; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE INHIBITORS; MODELS, MOLECULAR; RATS; SOLUBILITY; SULFONAMIDES;

CANIS FAMILIARIS; RATTUS;

EID: 84880602164     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.05.089     Document Type: Article

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