Elevated expression of adrenomedullin is correlated with prognosis and disease severity in osteosarcoma

Medical Oncology

Volumn 30, Issue 1, 2013, Pages

  Dai, Xing ^a   Ma, Wei ^a   He, Xijing J ^a   Jha, Rajiv Kumar ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Adrenomedullin; MG 63; Osteosarcoma; RNAi

Indexed keywords

MENINGIOMA ASSOCIATED PROTEIN 30; TUMOR MARKER; UNCLASSIFIED DRUG; ADRENOMEDULLIN; SMALL INTERFERING RNA;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER PATIENT; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER SURVIVAL; CANCER TISSUE; CONTROLLED STUDY; CYTOREDUCTIVE SURGERY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; OVARY CARCINOMA; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROTEIN EXPRESSION; ADOLESCENT; ANIMAL; BAGG ALBINO MOUSE; BONE TUMOR; CHILD; MALE; METABOLISM; MOUSE; NUDE MOUSE; OSTEOSARCOMA; PATHOLOGY; PROGNOSIS; RADIOIMMUNOASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADOLESCENT; ADRENOMEDULLIN; ADULT; ANIMALS; BONE NEOPLASMS; CHILD; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; OSTEOSARCOMA; PROGNOSIS; RADIOIMMUNOASSAY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84880594040     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-012-0347-0     Document Type: Article

References (21)

1. Caudill JS, Arndt CA. Diagnosis and management of bone malignancy in adolescence. Adolesc Med State Art Rev. 2007;18:62-78. ix.
2. Bacci G, Rocca M, Salone M, et al. High grade osteosarcoma of the extremities with lung metastases at presentation: treatment with neoadjuvant chemotherapy and simultaneous resection of primary and metastatic lesions. J Surg Oncol. 2008;98:415-20.
3. Bacci G, Longhi A, Versari M, et al. Prognostic factors for osteosarcoma of the extremity treated with neoadjuvant chemotherapy: 15-year experience in 789 patients treated at a single institution. Cancer. 2006;106:1154-61.
4. Shichiri M, Fukai N, Ozawa N, et al. Adrenomedullin is an autocrine/paracrine growth factor for rat vascular smooth muscle cells. Regul Pept. 2003;112:167-73.
5. Nikitenko LL, Fox SB, Kehoe S, et al. Adrenomedullin and tumour angiogenesis. Br J Cancer. 2006;94:1-7.
6. Zudaire E, Martinez A, Garayoa M, et al. Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis. Am J Pathol. 2006;168:280-91.
7. Fox SB, Generali DG, Harris AL. Breast tumour angiogenesis. Breast Cancer Res. 2007;9(6):216.
8. Ramachandran V, Arumugam T, Langley R, et al. The ADMR receptor mediates the effects of adrenomedullin on pancreatic cancer cells and on cells of the tumor microenvironment. PLoS ONE. 2009;4(10):e7502.
9. Rocchi P, Boudouresque F, Zamora AJ, et al. Expression of adrenomedullin and peptide amidation activity in human prostate cancer and in human prostate cancer cell lines. Cancer Res. 2001;61:1196-206.
10. Sakata J, Shimokubo T, Kitamura K, et al. Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide. Biochem Biophys Res Commun. 1993;195:921-7.
11. Nuki C, Kawasaki H, Kitamura K, et al. Vasodilator effect of adrenomedullin and calcitonin gene-related peptide receptors in rat mesenteric vascular beds. Biochem Biophys Res Commun. 1993;196:245-51.
12. Kanazawa H, Kurihara N, Hirata K, et al. Adrenomedullin, a newly discovered hypotensive peptide, is a potent bronchodilator. Biochem Biophys Res Commun. 1994;205:251-4.
13. Martinez A, Weaver C, Lopez J, et al. Regulation of insulin secretion and blood glucose metabolism by adrenomedullin. Endocrinology. 1996;137:2626-32.
14. Allen MA, Ferguson AV. In vitro recordings from area postrema neurons demonstrate responsiveness to adrenomedullin. Am J Physiol. 1996;270:R920-5.
15. Jougasaki M, Burnett JC Jr. Adrenomedullin as a renal regulator peptide. Nephrol Dial Transplant. 2000;15:293-5.
16. Ichikawa-Shindo Y, Sakurai T, Kamiyoshi A, et al. The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. J Clin Invest. 2008;118:29-39.
17. Hague S, Zhang L, Oehler MK, et al. Expression of the hypoxically regulated angiogenic factor adrenomedullin correlates with uterine leiomyoma vascular density. Clin Cancer Res. 2000;6:2808-14.
18. Oehler MK, Norbury C, Hague S, et al. Adrenomedullin inhibits hypoxic cell death by upregulation of Bcl-2 in endometrial cancer cells: a possible promotion mechanism for tumour growth. Oncogene. 2001;20:2937-45.
19. Kaafarani I, Fernandez-Sauze S, Berenguer C, et al. Targeting adrenomedullin receptors with systemic delivery of neutralizing antibodies inhibits tumor angiogenesis and suppresses growth of human tumor xenografts in mice. FASEB J. 2009;23:3424-35.
20. Ouafik L, Sauze S, Boudouresque F, et al. Neutralization of adrenomedullin inhibits the growth of human glioblastoma cell lines in vitro and suppresses tumor xenograft growth in vivo. Am J Pathol. 2002;160:1279-92.
21. Nunobiki O, Nakamura M, Taniguchi E, et al. Adrenomedullin, Bcl-2 and microvessel density in normal, hyperplastic and neoplastic endometrium. Pathol Int. 2009;59:530-6.