Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 16, 2013, Pages 4517-4522

  Hornberger, Keith R ^a   Berger, Dan M ^a   Crew, Andrew P ^a   Dong, Hanqing ^a   Kleinberg, Andrew ^a   Li, An Hu ^a   Medeiros, Matthew R ^a   Mulvihill, Mark J ^a   Siu, Kam ^a   Tarrant, James ^a   Wang, Jing ^a   Weng, Felix ^a   Wilde, Victoria L ^a   Albertella, Mark ^a   Bittner, Mark ^a   Cooke, Andrew ^a   Gray, Michael J ^a   Maresca, Paul ^a   May, Earl ^a   Meyn, Peter ^a   Peick, William ^a   Romashko, Darlene ^a   Tanowitz, Michael ^a   Tokar, Brianna ^a   more..

^a OSI PHARMACEUTICALS INC   (United States)

Author keywords

7 Amino furo 2,3 c pyridine; Cancer; Inflammation; Inhibitors; TAK1

Indexed keywords

7 AMINOFURO[2,3 C]PYRIDINE DERIVATIVE; PROTEIN SERINE THREONINE KINASE INHIBITOR; PYRIDINE DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; HIGH THROUGHPUT SCREENING;

EID: 84880590144     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.06.053     Document Type: Article

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