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Volumn 23, Issue 16, 2013, Pages 4511-4516
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Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: Optimization of kinase selectivity and pharmacokinetics
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Author keywords
7 Amino furo 2,3 c pyridine; Cancer; Inflammation; Inhibitors; TAK1
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Indexed keywords
7 AMINOFURO[2,3 C]PYRIDINE;
DRUG METABOLITE;
PHOSPHOTRANSFERASE INHIBITOR;
PYRIDINE DERIVATIVE;
TRANSFORMING GROWTH FACTOR BETA RECEPTOR ASSOCIATED KINASE 1 INHIBITOR;
UNCLASSIFIED DRUG;
ANIMAL CELL;
ARTICLE;
CRYSTAL STRUCTURE;
DRUG BIOAVAILABILITY;
DRUG CLEARANCE;
DRUG SELECTIVITY;
ENTEROHEPATIC CIRCULATION;
HIGH THROUGHPUT SCREENING;
HUMAN;
HUMAN CELL;
NONHUMAN;
PHYSICAL CHEMISTRY;
SONOGASHIRA REACTION;
STILLE REACTION;
SUZUKI REACTION;
TUMOR XENOGRAFT;
7-AMINO-FURO[2,3-C]PYRIDINE;
CANCER;
INFLAMMATION;
INHIBITORS;
TAK1;
AMINES;
ANIMALS;
CRYSTALLOGRAPHY, X-RAY;
ENZYME ACTIVATION;
ENZYME INHIBITORS;
FURANS;
HUMANS;
INHIBITORY CONCENTRATION 50;
MAP KINASE KINASE KINASES;
MICE;
MOLECULAR STRUCTURE;
NEOPLASMS;
PHOSPHOTRANSFERASES;
PYRIDINES;
STRUCTURE-ACTIVITY RELATIONSHIP;
XENOGRAFT MODEL ANTITUMOR ASSAYS;
MUS;
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EID: 84880633668
PISSN: 0960894X
EISSN: 14643405
Source Type: Journal
DOI: 10.1016/j.bmcl.2013.06.054 Document Type: Article |
Times cited : (22)
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References (13)
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