Multi-institutional prospective evaluation of bowel quality of life after prostate external beam radiation therapy identifies patient and treatment factors associated with patient-reported outcomes: The PROSTQA experience

International Journal of Radiation Oncology Biology Physics

Volumn 86, Issue 3, 2013, Pages 546-553

  Hamstra, Daniel A ^a   Conlon, Anna S C ^b   Daignault, Stephanie ^b   Dunn, Rodney L ^a   Sandler, Howard M ^c   Hembroff, A Larry ^d   Zietman, Anthony L ^e   Kaplan, Irving ^f   Ciezki, Jay ^g   Kuban, Deborah A ^h   Wei, John T ^a   Sanda, Martin G ⁱ   Michalski, Jeff M ^j  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

^d MICHIGAN STATE UNIVERSITY   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^g LERNER RESEARCH INSTITUTE   (United States)

^h UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

ⁱ EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTERIZED TOMOGRAPHY; DISEASES; MULTIVARIANT ANALYSIS; PATIENT MONITORING; QUALITY CONTROL; RADIATION; RADIOTHERAPY; UROLOGY;

EXPANDED PROSTATE CANCER INDEX COMPOSITES; EXTERNAL BEAM RADIATION THERAPY; HEALTH-RELATED QUALITY OF LIVES; INTENSITY MODULATED RADIATION THERAPY; LOCALIZED PROSTATE CANCER; PATIENT-REPORTED OUTCOMES; PROSPECTIVE EVALUATION; RADIATION THERAPY TREATMENT;

PATIENT TREATMENT;

ACETYLSALICYLIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTATE SPECIFIC ANTIGEN;

ADULT; AGED; ARTICLE; EVALUATION STUDY; EXTERNAL BEAM RADIOTHERAPY; FECES INCONTINENCE; HUMAN; INTENSITY MODULATED RADIATION THERAPY; INTESTINE FUNCTION; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTICENTER STUDY; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; PROSTATE CANCER; QUALITY OF LIFE; RADIATION DOSE; RECTUM; RECTUM HEMORRHAGE; VERY ELDERLY; ANALYSIS OF VARIANCE; CONFIDENCE INTERVAL; GASTROINTESTINAL HEMORRHAGE; PATIENT SATISFACTION; PROSTATE; PROSTATE TUMOR; PSYCHOLOGICAL ASPECT; RADIATION EXPOSURE; RECTUM DISEASE; SEVERITY OF ILLNESS INDEX; UNITED STATES;

AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; CONFIDENCE INTERVALS; FECAL INCONTINENCE; GASTROINTESTINAL HEMORRHAGE; HUMANS; MALE; MIDDLE AGED; PATIENT SATISFACTION; PROSPECTIVE STUDIES; PROSTATE; PROSTATIC NEOPLASMS; QUALITY OF LIFE; RADIOTHERAPY DOSAGE; RADIOTHERAPY, INTENSITY-MODULATED; RECTAL DISEASES; RECTUM; SEVERITY OF ILLNESS INDEX; UNITED STATES;

MLCS; MLOWN;

EID: 84880582318     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2013.01.036     Document Type: Article

References (23)

1. Sanda MG, Dunn RL, Michalski J, et al. Quality of life and satisfaction with outcome among prostate-cancer survivors. N Engl J Med 2008;358:1250-1261.
2. Wei JT, Dunn RL, Litwin MS, et al. Development and validation of the expanded prostate cancer index composite (EPIC) for comprehensive assessment of health-related quality of life in men with prostate cancer. Urology 2000;56:899-905.
3. Michalski JM, Gay H, Jackson A, et al. Radiation dose-volume effects in radiation-induced rectal injury. Int J Radiat Oncol Biol Phys 2010; 76:S123-S129.
4. Pollack A, Zagars GK, Starkschall G, et al. Prostate cancer radiation dose response: Results of the M. D. Anderson phase III randomized trial. Int J Radiat Oncol Biol Phys 2002;53:1097-1105.
5. Sandler HM, Liu PY, Dunn RL, et al. Reduction in patient-reported acute morbidity in prostate cancer patients treated with 81-Gy Intensity-modulated radiotherapy using reduced planning target volume margins and electromagnetic tracking: assessing the impact of margin reduction study. Urology 2010;75:1004-1008.
6. Radiation Therapy Oncology Group. RTOG 0126: A phase III randomized study of high dose 3DCRT/IMRT versus standard dose 3DCRT/IMRT in patients treated for localized prostate cancer. Available at: http://www.rtog.org/ClinicalTrials/ ProtocolTable/StudyDetails.aspx'studyZ0126. Accessed 3/1/2012.
7. Dunn RL, Sanda MG, Wei JT. Minimally important difference for the Expanded Prostate Cancer Index Composite (EPIC). Papper presented at the 16th Annual Conference of the International Society for Quality of Life Research; 2009; New Orleans, LA.
8. Speight JL, Roach M 3rd. Radiotherapy in the management of clinically localized prostate cancer: Evolving standards, consensus, controversies and new directions. J Clin Oncol 2005;23:8176-8185.
9. Koper PC, Jansen P, van Putten W, et al. Gastro-intestinal and genito-urinary morbidity after 3D conformal radiotherapy of prostate cancer: Observations of a randomized trial. Radiother Oncol 2004;73:1-9.
10. Peeters ST, Heemsbergen WD, van Putten WL, et al. Acute and late complications after radiotherapy for prostate cancer: Results of a multicenter randomized trial comparing 68 Gy to 78 Gy. Int J Radiat Oncol Biol Phys 2005;61:1019-1034.
11. Peeters ST, Lebesque JV, Heemsbergen WD, et al. Localized volume effects for late rectal and anal toxicity after radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys 2006;64:1151-1161.
12. Fiorino C, Fellin G, Rancati T, et al. Clinical and dosimetric predictors of late rectal syndrome after 3D-CRT for localized prostate cancer: Preliminary results of a multicenter prospective study. Int J Radiat Oncol Biol Phys 2008;70:1130-1137.
13. Mavroidis P, al-Abany M, Helgason AR, et al. Dose-response relations for anal sphincter regarding fecal leakage and blood or phlegm in stools after radiotherapy for prostate cancer. Radiobiological study of 65 consecutive patients. Strahlenther Onkol 2005; 181:293-306.
14. Tucker SL, Dong L, Michalski JM, et al. Do intermediate radiation doses contribute to late rectal toxicity' An analysis of data from radiation therapy oncology group protocol 94-06. Int J Radiat Oncol Biol Phys 2012;84:390-395.
15. Namiki S, Ishidoya S, Tochigi T, et al. Health-related quality of life after intensity modulated radiation therapy for localized prostate cancer: Comparison with conventional and conformal radiotherapy. Jpn J Clin Oncol 2006;36:224-230.
16. Pinkawa M, Piroth MD, Holy R, et al. Quality of life after whole pelvic versus prostate-only external beam radiotherapy for prostate cancer: A matched-pair comparison. Int J Radiat Oncol Biol Phys 2011;81:23-28.
17. Roach M 3rd, DeSilvio M, Valicenti R, et al. Whole-pelvis, 'minipelvis, ' or prostate-only external beam radiotherapy after neoadjuvant and concurrent hormonal therapy in patients treated in the Radiation Therapy Oncology Group 9413 trial. Int J Radiat Oncol Biol Phys 2006;66:647-653.
18. Pommier P, Chabaud S, Lagrange JL, et al. Is there a role for pelvic irradiation in localized prostate adenocarcinoma' Preliminary results of GETUG-01. J Clin Oncol 2007;25:5366-5373.
19. Guedea F, Ferrer M, Pera J, et al. Quality of life two years after radical prostatectomy, prostate brachytherapy or external beam radiotherapy for clinically localised prostate cancer: The Catalan Institute of Oncology/Bellvitge Hospital experience. Clin Transl Oncol 2009;11: 470-478.
20. Hoppe BS, Nichols RC, Henderson RH, et al. Erectile function, incontinence, and other quality of life outcomes following proton therapy for prostate cancer in men 60 years old and younger. Cancer 2012;118:4619-4626.
21. Miller DC, Sanda MG, Dunn RL, et al. Long-term outcomes among localized prostate cancer survivors: Health-related quality-of-life changes after radical prostatectomy, external radiation, and brachytherapy. J Clin Oncol 2005;23:2772-2780.
22. Kim S, Shen S, Moore DF, et al. Late gastrointestinal toxicities following radiation therapy for prostate cancer. Eur Urol 2011;60:908-916.
23. Hamstra DA, Stenmark M, Ritter T, et al. Age and comorbid illness are associated with late rectal toxicity following dose-escalated radiation therapy for prostate cancer. Int J Radiat Oncol Biol Phys 2013; 85:1246-1253.