Age and comorbid illness are associated with late rectal toxicity following dose-escalated radiation therapy for prostate cancer

International Journal of Radiation Oncology Biology Physics

Volumn 85, Issue 5, 2013, Pages 1246-1253

  Hamstra, Daniel A ^a   Stenmark, Matt H ^a,b   Ritter, Tim ^a,b   Litzenberg, Dale ^a   Jackson, William ^a   Johnson, Skyler ^a   Albrecht Unger, Liesel ^a   Donaghy, Alex ^a   Phelps, Laura ^a   Blas, Kevin ^a   Halverson, Schuyler ^a   Marsh, Robin ^a   Olson, Karin ^a   Feng, Felix Y ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONGESTIVE HEART FAILURES; COX PROPORTIONAL HAZARDS MODELS; EXTERNAL BEAM RADIATION THERAPY; LATE RECTAL TOXICITIES; METHODS AND MATERIALS; MULTI VARIATE ANALYSIS; MYOCARDIAL INFARCTION; NORMAL-TISSUE COMPLICATION PROBABILITY MODELS;

DISEASES; EPIDEMIOLOGY; RADIOTHERAPY; TISSUE;

TOXICITY;

ADULT; AGE; AGED; ANDROGEN DEPRIVATION THERAPY; ARTICLE; CANCER RADIOTHERAPY; CHARLSON COMORBIDITY INDEX; COMORBIDITY; DISEASE ASSOCIATION; EXTERNAL BEAM RADIOTHERAPY; FOLLOW UP; HIGH RISK PATIENT; HUMAN; IMAGE GUIDED RADIOTHERAPY; INTENSITY MODULATED RADIATION THERAPY; MAJOR CLINICAL STUDY; MALE; PELVIS LYMPH NODE; PRIORITY JOURNAL; PROSTATE CANCER; RADIATION DOSE ESCALATION; RADIATION RESPONSE; RECTUM; TOXICITY;

AGE FACTORS; AGED; AGED, 80 AND OVER; ANTICOAGULANTS; COMORBIDITY; HEART FAILURE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; MODELS, STATISTICAL; MULTIVARIATE ANALYSIS; MYOCARDIAL INFARCTION; ORGANS AT RISK; PROSTATIC NEOPLASMS; RADIATION INJURIES; RADIOTHERAPY DOSAGE; RADIOTHERAPY, IMAGE-GUIDED; RADIOTHERAPY, INTENSITY-MODULATED; RECTUM; TIME FACTORS;

EID: 84875255027     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2012.10.042     Document Type: Article

References (13)

1. J.M. Michalski, H. Gay, and A. Jackson Radiation dose volume effects in radiation-induced rectal injury Int J Radiat Oncol Biol Phys 76 3 Suppl 2010 S123 S129
2. W.G. Smit, P.A. Helle, and W.L.J. Van Putten Late radiation damage in prostate cancer patients treated by high dose external radiotherapy in relation to rectal dose Int J Radiat Oncol Biol Phys 18 1990 23 29
3. M.J. Zelefsky, E.J. Levin, and M. Hunt Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity modulated radiotherapy for localized prostate cancer Int J Radiat Oncol Biol Phys 70 2008 1124 1129
4. M. Skwarchuk, A. Jackson, and M. Zelefsky Late rectal toxicity after 3D-conformal radiation therapy of prostate cancer: Multivariate analysis and dose-response Int J Radiat Oncol Biol Phys 47 2000 103 113
5. S.M. Bentzen, L.S. Constine, and J.O. Deasy Quantitative analyses of normal tissue effects in the clinic (QUANTEC): an introduction to the scientific issues Int J Radiat Oncol Biol Phys 76 suppl3 2010 S3 S9
6. M.E. Charlson, P. Pompei, and K.L. Ales A new method of classifying prognostic comorbidity in longitudinal studies: development and validation J Chronic Dis 40 1987 373 383
7. Z. Symon, K.A. Griffith, and P.W. McLaughlin Dose escalation for localized prostate cancer: substantial benefit observed with 3D conformal therapy Int J Radiat Oncol Biol Phys 57 2003 384 390
8. J.D. Cox, J. Stetz, and T.F. Pajak Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) Int J Radiat Oncol Biol Phys 31 1995 1341 1346
9. M. Liu, V. Moiseenko, and A. Agranovich Normal tissue complication probability (NTCP) modeling of late rectal bleeding following external beam radiotherapy for prostate cancer: a test of the QUANTEC-recommended NTCP model Acta Oncologica 49 2010 1040 1044
10. S.L. Tucker, L. Dong, and W.R. Bosch Late rectal toxicity on RTOG 94-06: analysis using a mixture Lyman model Int J Radiat Oncol Biol Phys 78 2010 1253 1260
11. S.L. Tucker, L. Dong, and J.M. Michalski Do intermediate radiation doses contribute to late rectal toxicity? An analysis of data from radiation therapy oncology group protocol 94-06 Int J Radiat Oncol Biol Phys 84 2012 390 395
12. S. Kim, S. Shen, and D.F. Moore Late gastrointestinal toxicities following radiation therapy for prostate cancer Eur Urol 60 2011 908 916
13. K.S. Choe, A.B. Jani, and S.L. Liauw External beam radiotherapy for prostate cancer patients on anticoagulation therapy: how significant is the bleeding toxicity? Int J Radiat Oncol Biol Phys 76 2010 755 760