Dose-response relations for anal sphincter regarding fecal leakage and blood or phlegm in stools after radiotherapy for prostate cancer: Radiobiological study of 65 consecutive patients

Strahlentherapie und Onkologie

Volumn 181, Issue 5, 2005, Pages 293-306

  Mavroidis, Panayiotis ^a,b   Al Abany, Massoud ^c   Helgason, Ásgeir R ^d   Cronqvist, Anna Karin Ågren ^e   Wersäll, Peter ^f   Lind, Helena ^f   Qvanta, Eva ^f   Theodorou, Kyriaki ^b   Kappas, Constantin ^b   Lind, Bengt K ^a   Steineck, Gunnar ^c   Brahme, Anders ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b UNIVERSITY HOSPITAL OF LARISSA   (Greece)

^c KAROLINSKA INSTITUTE   (Sweden)

^d Stockholm Centre of Public Health   (Sweden)

^e STOCKHOLM SÖDER HOSPITAL   (Sweden)

^f KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Blood or phlegm in stools; Fecal leakage; NTCP; Prostate cancer; Radiobiological parameters; Relative seriality

Indexed keywords

ADULT; AGED; ANUS SPHINCTER; ANUS SPHINCTER DISORDER; ARTICLE; CANCER RADIOTHERAPY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DOSE RESPONSE; FECES ANALYSIS; FOLLOW UP; HEMATOCHEZIA; HUMAN; MAJOR CLINICAL STUDY; MALE; PREDICTION; PROSTATE CARCINOMA; QUESTIONNAIRE; RADIATION DOSE; RECEIVER OPERATING CHARACTERISTIC;

AGED; ANAL CANAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; FECAL INCONTINENCE; HUMANS; MALE; MIDDLE AGED; OCCULT BLOOD; PROSTATIC NEOPLASMS; RADIOTHERAPY;

EID: 20044374374     PISSN: 01797158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00066-005-1313-y     Document Type: Article

References (48)

1. Aaltonen P, Brahme A, Lax I, et al. Specification of dose delivery in radiation therapy. Recommendations by the Nordic Association of Clinical Physics (NACP). Acta Oncol 1997;10:Suppl:1-32.
2. Ågren A-K. Quantification of the response of heterogeneous tumors and organized normal tissues to fractionated radiotherapy. Thesis, Stockholm University, 1995.
3. Ågren A-K, Brahme A, Turesson I. Optimization of uncomplicated control for head and neck tumors. Int J Radiat Oncol Biol Phys 1990;19:1077-85.
4. Al-abany M. Towards elimination of anal-sphincter and rectal dysfunction after radiation therapy for prostate cancer. Thesis, Karolinska Institutet, Stockholm, 2004.
5. Al-abany M, Helgason AR, Ågren Cronqvist AK, et al. Long-term symptoms after external beam radiation therapy for prostate cancer with three or four fields. Acta Oncol 2002;41:532-42.
6. Al-abany M, Helgason AR, Ågren Cronqvist AK, et al. Dose to the anal sphincter region and risk of fecal leakage. Acta Oncol 2004;43:117-8.
7. Al-abany M, Helgason AR, Ågren Cronqvist AK, et al. Towards a definition of a threshold for harmless doses to the anal-sphincter region and the rectum. Int J Radiat Oncol Biol Phys 2005;61:1035-44.
8. Anseline PF, Lavery IC, Fazio VW, et al. Radiation injury of the rectum. Ann Surg 1981;194:716-24.
9. Archambeau JO, Shymko RM. Tissue population configuration as a modifier of organ response. Int J Radiat Oncol Biol Phys 1988;15:727-34.
10. Bergmark K, Avall-Lundqvist E, Dickman PW, et al. Vaginal changes and sexuality in women with a history of cervical cancer. N Engl J Med 1999;340:1383-9.
11. Brahme A. Treatment optimization using physical and biological objective functions. In: Smith A, ed. Radiation therapy physics. Berlin: Springer, 1995:209-46.
12. Cho KH, Lee CK, Levitt SH. Proctitis after conventional external radiation therapy for prostate cancer: importance of minimizing posterior rectal dose. Radiology 1995;195:699-703.
13. Dearnaley DP, Khoo VS, Norman AR, et al. Comparison of radiation side-effects of conformal and conventional radiotherapy in prostate cancer: a randomized trial. Lancet 1999;353:267-72.
14. De Meerleer G, Vakaet L, De Gersem W, et al. Direct segment aperture and weight optimization for intensity-modulated radiotherapy of prostate cancer. Strahlenther Onkol 2004;180:136-43.
15. De Meerleer GO, Villeirs GM, Vakaet L, et al. The incidence of inclusion of the sigmoid colon and small bowel in the planning target volume in radiotherapy for prostate cancer. Strahlenther Onkol 2004;180:573-81.
16. Eadie WT, Drijard D, James FE, et al. Statistical methods in experimental physics. CERN: North-Holland Publishing, 1971.
17. Emami B, Lyman J, Brown A, et al. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 1991;21:109-22.
18. Eriksson F, Gagliardi G, Liendberg A, et al. Long-term cardiac mortality following radiation therapy for Hodgkin's disease: analysis with the relative seriality model. Radiother Oncol 2000;55:153-62.
19. Fowler JF. Brief summary of radiobiological principles in fractionated radiotherapy. Semin Radiat Oncol 1992;2:16-21.
20. Gagliardi G, Bjöhle J, Lax I, et al. Radiation pneumonitis after breast cancer irradiation: analysis of the complication probability using the relative seriality model. Int J Radiat Oncol Biol Phys 2000;46:373-81.
21. Goldner G, Wachter-Gerstner N, Wachter S, et al. Acute side effects during 3-D-planned conformal radiotherapy of prostate cancer. Strahlenther Onkol 2003;179:320-7.
22. Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 1982;143:29-36.
23. Hartford AC, Niemierko A, Adams JA, et al. Conformal irradiation of the prostate: estimating long-term rectal bleeding risk using dose-volume histograms. Int J Radiat Oncol Biol Phys 1996;36:721-31.
24. Jackson A, Skwarchuk MW, Zelefsky MJ, et al. Late rectal bleeding after conformal radiotherapy of prostate cancer. II. Volume effects and dose-volume histograms. Int J Radiat Oncol Biol Phys 2001;49:685-98.
25. Jackson A, Ten Haken RK, Robertson JM, et al. Analysis of clinical complication data for radiation hepatitis using a parallel architecture model. Int J Radiat Oncol Biol Phys 1995;31:883-91.
26. Källman P, Ågren A-K, Brahme A. Tumor and normal tissue responses to fractionated non-uniform dose delivery. Int J Radiat Biol 1992;62:249-62.
27. Källman P, Lind BK, Brahme A. An algorithm for maximizing the probability of complication-free tumor control in radiation therapy. Phys Med Biol 1992;37:871-90.
28. Karlsson B, Lax I, Söderman M. Can the probability for obliteration after radiosurgery of arteriovenous malformations be accurately predicted? Int J Radiat Oncol Biol Phys 1999;43:313-9.
29. Kölbl O, Richter S, Flentje M. Influence of treatment technique on dose-volume histogram and normal tissue complication probability for small bowel and bladder. Strahlenther Onkol 2000;176:105-11.
30. Kouloulias VE, Kouvaris JR, Pissakas G, et al. A phase II randomized study of topical intrarectal administration of amifostine for the prevention of acute radiation-induced rectal toxicity. Strahlenther Onkol 2004;180:557-62.
31. Lebesque JV, Bruce AM, Kroes AP, et al. Variation in volumes, dose-volume histograms and estimated normal tissue complication probabilities of rectum and bladder during conformal radiotherapy of T3 prostate cancer. Int J Radiat Oncol Biol Phys 1995;33:1109-19.
32. Lind BK, Källman P, Sundelin B, et al. Optimal radiation beam profiles considering uncertainties in beam patient alignment. Acta Oncol 1993;32:331-42.
33. Lind BK, Mavroidis P, Hyödynmaa S, et al. Optimization of the dose level for a given treatment plan to maximize the complication-free tumor cure. Acta Oncol 1999;38:787-98.
34. Löf J, Lind BK, Brahme A. Optimal radiation beam profiles considering the stochastic process of patient positioning in fractionated radiation therapy. Inverse Problems 1995;11:1189-209.
35. Mavroidis P, Laurell G, Kraepelien T, et al. Determination and clinical verification of dose-response parameters for esophageal stricture from head and neck radiotherapy. Acta Oncol 2003;42:865-81.
36. = for specification, report and comparison of dose response relations and treatment plans. Phys Med Biol 2001;46:2607-30.
37. Mavroidis P, Lind BK, Theodorou K, et al. Statistical methods for clinical verification of dose-response parameters related to esophageal stricture and AVM obliteration from radiotherapy. Phys Med Biol 2004;49:3797-816.
38. Mavroidis P, Lind BK, Van Dijk J, et al. Comparison of conformal radiation therapy techniques within the dynamic radiotherapy project "DYNARAD". Phys Med Biol 2000;45:2459-81.
39. Mayer R, Pummer K, Quehenberger F, et al. Analysis of competing risk parameters in irradiated prostate cancer patients. Strahlenther Onkol 2003;179:452-7.
40. Michalski JM, Purdy JA, Winter K, et al. Preliminary report of toxicity following 3D radiation therapy for prostate cancer on 3DOG/RTOG 9406. Int J Radiat Oncol Biol Phys 2000;46:391-402.
41. Murtagh BA, Saunders MA. MINOS 5.4 user's guide, technical report SOL 83-20R, Department of operations research. Standford: Standford University, 1995.
42. Roeske JC, Forman JD, Mesina CF, et al. Evaluation of changes in the size and location of the prostate, seminal vesicles, bladder and rectum during a course of external beam radiation therapy. Int J Radiat Oncol Biol Phys 1995;33:1321-9.
43. Sanguineti G, Castellone P, Foppiano F, et al. Anatomic variations due to radical prostatectomy impact on target volume definition and dose-volume parameters of rectum and bladder. Strahlenther Onkol 2004;180:563-72.
44. Steineck G, Bergmark K, Henningsohn L, et al. Symptom documentation in cancer survivors as a basis for therapy modifications. Acta Oncol 2002;41:244-52.
45. Venkatraman ES, Begg C. A distribution-free procedure for comparing receiver operating characteristic curves from a paired experiment. Biometrika 1996;83:835-48.
46. Widmark A, Fransson P, Tavelin B. Self-assessment questionnaire for evaluating urinary and intestinal late side effects after pelvic radiotherapy in patients with prostate cancer compared with an age-matched control population. Cancer 1994;74:2520-32.
47. Yeoh EE, Botten R, Russo A, et al. Chronic effects of therapeutic irradiation for localized prostatic carcinoma on anorectal function. Int J Radiat Oncol Biol Phys 2000;47:915-24.
48. Yeoh EK, Russo A, Botten R, et al. Acute effects of therapeutic irradiation for prostatic carcinoma on anorectal function. Gut 1998;43:123-7.