Autologous transplantation of adipose-derived stem cells enhances skin graft survival and wound healing in diabetic rats

Annals of Plastic Surgery

Volumn 71, Issue 2, 2013, Pages 225-232

  Zografou, Aggeliki ^a   Papadopoulos, Othon ^a   Tsigris, Christos ^a   Kavantzas, Nikolaos ^a   Michalopoulos, Efstathios ^b   Chatzistamatiou, Theofanis ^b   Papassavas, Andreas ^b   Stavropoulou Gioka, Catherine ^b   Dontas, Ismini ^a   Perrea, Despoina ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b BIOMEDICAL RESEARCH FOUNDATION   (Greece)

Author keywords

adipose derived stem cells; angiogenesis; diabetic rats; skin graft; TGF A3; VEGF; wound healing

Indexed keywords

BIOLOGICAL MARKER; STREPTOZOCIN; TRANSFORMING GROWTH FACTOR BETA3; VASCULAR ENDOTHELIAL GROWTH FACTOR A, RAT; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL; AUTOTRANSPLANTATION; CELL CULTURE; CELL DIFFERENTIATION; CHEMICALLY INDUCED; CYTOLOGY; EVALUATION STUDY; EXPERIMENTAL DIABETES MELLITUS; GRAFT SURVIVAL; MALE; METABOLISM; PHYSIOLOGY; PROCEDURES; RANDOMIZATION; RAT; SKIN TRANSPLANTATION; SPRAGUE DAWLEY RAT; STEM CELL TRANSPLANTATION; SUBCUTANEOUS FAT; WOUND HEALING; ARTICLE; CHEMICALLY INDUCED DISORDER; METHODOLOGY;

ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; GRAFT SURVIVAL; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SKIN TRANSPLANTATION; STEM CELL TRANSPLANTATION; STREPTOZOCIN; SUBCUTANEOUS FAT; TRANSFORMING GROWTH FACTOR BETA3; TRANSPLANTATION, AUTOLOGOUS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 84880573343     PISSN: 01487043     EISSN: 15363708     Source Type: Journal    
DOI: 10.1097/SAP.0b013e31826af01a     Document Type: Article

References (37)

1. Menke NB, Ward KR, Witten TM, et al. Impaired wound healing [review]. Clin Dermatol. 2007;25:19-25.
2. Medina A, Scott PG, Ghahary A, et al. Pathophysiology of chronic nonhealing wounds. J Burn Care Rehabil. 2005;26:306-319.
3. Keswani SG, Katz AB, Lim FY, et al. Adenoviral mediated gene transfer of PDGF-B enhances wound healing in type I and type II diabetic wounds. Wound Repair Regen. 2004;12:497-504.
4. Spanheimer RG, Umpierrez GE, Stumpf V. Decreased collagen production in diabetic rats. Diabetes. 1988;37:371-376.
5. Steed DL. Modifying the wound healing response with exogenous growth factors. Clin Plast Surg. 1998;25:397-405.
6. Tsang MW, Wong WK, Hung CS, et al. Human epidermal growth factor enhances healing of diabetic foot ulcers. Diabetes Care. 2003;26:1856-1861.
7. Embil JM, Papp K, Sibbald G, et al. Recombinant human platelet-derived growth factor-BB (becaplermin) for healing chronic lower extremity diabetic ulcers: an open-label clinical evaluation of efficacy. Wound Repair Regen. 2000;8:162-168.
8. Vooijs DP, Walboomers XF, Parker JA, et al. Transforming growth factor-beta3-loaded microtextured membranes for skin regeneration in dermal wounds. J Biomed Mater Res A. 2004;70:402-411.
9. Planat-Benard V, Silvestre JS, Cousin B, et al. Plasticity of human adipose lineage cells toward endothelial cells: physiological and therapeutic perspectives. Circulation. 2004;109:656-663.
10. Miranville A, Heeschen C, Sengenes C, et al. Improvement of postnatal neovascularization by human adipose tissue-derived stem cells. Circulation. 2004;110:349-355.
11. Rehman J, Traktuev D, Li J, et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation. 2004;109:1292-1298.
12. Lee EY, Xia Y, Kim WS, et al. Hypoxia-enhanced wound-healing function of adipose-derived stem cells: increase in stem cell proliferation and up-regulation of VEGF and bFGF. Wound Repair Regen. 2009;17:540-547.
13. Kim WS, Park BS, Sung JH. The wound-healing and antioxidant effects of adipose-derived stem cells [review]. Expert Opin Biol Ther. 2009;9:879-887.
14. Nakagami H, Maeda K, Morishita R, et al. Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells. Arterioscler Thromb Vasc Biol. 2005;25:2542-2547.
15. Traktuev DO, Merfeld-Clauss S, Li J, et al. A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks. Circ Res. 2008;102:77-85.
16. Ebrahimian TG, Pouzoulet F, Squiban C, et al. Cell therapy based on adipose tissue-derived stromal cells promotes physiological and pathological wound healing. Arterioscler Thromb Vasc Biol. 2009;29:503-510.
17. Nambu M, Kishimoto S, Nakamura S, et al. Accelerated wound healing in healing-impaired db/db mice by autologous adipose tissue-derived stromal cells combined with atelocollagen matrix. Ann Plast Surg. 2009:62:317-321.
18. Nie C, Yang D, Xu J, et al. Locally administered adipose-derived stem cells accelerate wound healing through differentiation and vasculogenesis. Cell Transplant. 2011;20:205-216.
19. Cherubino M, Rubin JP, Miljkovic N, et al. Adipose-derived stem cells for wound healing applications. Ann Plast Surg. 2011;66:210-215.
20. Lu F, Mizuno H, Uysal CA, et al. Improved viability of random pattern skin flaps through the use of adipose-derived stem cells. Plast Reconstr Surg. 2008; 121:50-58.
21. Uysal CA, Ogawa R, Lu F, et al. Effect of mesenchymal stem cells on skin graft to flap prefabrication: an experimental study. Ann Plast Surg. 2010;65: 237-244.
22. Yeh JT, Lin CH, Lin YT. Skin grafting as a salvage procedure in diabetic foot reconstruction to avoid major limb amputation. Chang Gung Med J. 2010;33: 389-396.
23. Junod A, Lambert AE, Stauffacher W, et al. Diabetogenic action of strepto-zotocin: relation of dose to metabolic response. J Clin Invest. 1969;48: 2129-2139.
24. Zuk PA, Zhu M, Ashjian P, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 2002;13:4279-4295.
25. Zografou A, Tsigris C, Papadopoulos O, et al. Improvement of skin graft survival after autologous transplantation of adipose-derived stem cells in rats. J Plast Reconstr Aesthet Surg. 2011;64:1647-1656.
26. Mitchell JB, McIntosh K, Zvonic S, et al. The immunophenotype of human adipose-derived cells: temporal changes in stromal-associated and stem cell-associated markers. Stem Cells. 2006;24:376-385.
27. Kwon DS, Gao X, Liu YB, et al. Treatment with bone marrow-derived stromal cells accelerates wound healing in diabetic rats. Int Wound J. 2008;5:453-463.
28. Lerman OZ, Galiano RD, Armour M, et al. Cellular dysfunction in the diabetic fibroblast: impairment in migration, vascular endothelial growth factor production and response to hypoxia. Am J Pathol. 2003;162:303-312.
29. Bao P, Kodra A, Tomic-Canic M, et al. The role of vascular endothelial growth factor in wound healing. J Surg Res. 2009;153:347-358.
30. Klinger M, Marazzi M, Vigo D, et al. Fat injection for cases of severe burn outcomes: a new perspective of scar remodeling and reduction. Aesthetic Plast Surg. 2008;32:465-469.
31. Mojallal A, Lequeux C, Shipkov C, et al. Improvement of skin quality after fat grafting: clinical observation and an animal study. Plast Reconstr Surg. 2009; 124:765-774.
32. Rigotti G, Marchi A, Galie M, et al. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg. 2007;119:1409-1422.
33. Ferguson MW, O'Kane S. Scar-free healing: from embryonic mechanisms to adult therapeutic intervention. Philos Trans R Soc Lond B Biol Sci. 2004; 359:839-850.
34. Occleston NL, Fairlamb D, Hutchison J, et al. Avotermin for the improvement of scar appearance: a new pharmaceutical in a new therapeutic area [review]. Expert Opin Investig Drugs. 2009;18:1231-1239.
35. Bush J, Duncan JA, Bond JS, et al. Scar-improving efficacy of avotermin administered into the wound margins of skin incisions as evaluated by a randomized, double-blind, placebo-controlled, phase II clinical trial. Plast Reconstr Surg. 2010;126:1604-1615.
36. Lazic T, Falanga V. Bioengineered skin constructs and their use in wound healing. Plast Reconstr Surg. 2011;127(suppl 1):75S-90S.
37. Sterodimas A, de Faria J, Nicaretta B, et al. Tissue engineering with adipose-derived stem cells (ADSCs): current and future applications. J Plast Reconstr Aesthet Surg. 2010;63:1886-1892.