메뉴 건너뛰기




Volumn 18, Issue 8, 2009, Pages 1231-1239

Avotermin for the improvement of scar appearance: A new pharmaceutical in a new therapeutic area

Author keywords

Avotermin; Scar free healing; Scar improvement; Scarring; Skin; TGF 3

Indexed keywords

AVOTERMIN; JUVISTA; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA3; UNCLASSIFIED DRUG;

EID: 68049133319     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543780903130594     Document Type: Review
Times cited : (24)

References (37)
  • 1
    • 0030891107 scopus 로고    scopus 로고
    • Facial disfigurement
    • McGrouther DA. Facial disfigurement. BMJ 1997;314:991
    • (1997) BMJ , vol.314 , pp. 991
    • McGrouther, D.A.1
  • 2
    • 0033231968 scopus 로고    scopus 로고
    • Disfiguring burn scars and adolescent self-esteem
    • Robert R, Meyer W, Bishop S, et al. Disfiguring burn scars and adolescent self-esteem. Burns 1999;25:581-5
    • (1999) Burns , vol.25 , pp. 581-585
    • Robert, R.1    Meyer, W.2    Bishop, S.3
  • 3
    • 0034234893 scopus 로고    scopus 로고
    • Psychological difficulties amongst plastic surgery ex-patients following surgery to the face: A survey
    • Newell R. Psychological difficulties amongst plastic surgery ex-patients following surgery to the face: a survey. Br J Plast Surg 2000;53:386-92
    • (2000) Br J Plast Surg , vol.53 , pp. 386-392
    • Newell, R.1
  • 4
    • 0035001649 scopus 로고    scopus 로고
    • Optimal management of acne to prevent scarring and psychological sequelae
    • Layton AM. Optimal management of acne to prevent scarring and psychological sequelae. Am J Clin Dermatol 2001;2:135-41
    • (2001) Am J Clin Dermatol , vol.2 , pp. 135-141
    • Layton, A.M.1
  • 5
    • 0041829041 scopus 로고    scopus 로고
    • Exploring the psychosocial concerns of outpatients with disfiguring conditions
    • Rumsey N, Clarke A, White P. Exploring the psychosocial concerns of outpatients with disfiguring conditions. J Wound Care 2003;12:247-52
    • (2003) J Wound Care , vol.12 , pp. 247-252
    • Rumsey, N.1    Clarke, A.2    White, P.3
  • 7
    • 33846423887 scopus 로고    scopus 로고
    • Visual disfigurement and depression
    • Valente SM. Visual disfigurement and depression. Plast Surg Nurs 2004;24(4):140-6
    • (2004) Plast Surg Nurs , vol.24 , Issue.4 , pp. 140-146
    • Valente, S.M.1
  • 8
    • 23344454724 scopus 로고    scopus 로고
    • Clinical management of skin scarring
    • Bayat A, McGrouther DA. Clinical management of skin scarring. Skinmed 2005;4:165-73
    • (2005) Skinmed , vol.4 , pp. 165-173
    • Bayat, A.1    McGrouther, D.A.2
  • 9
    • 0036312318 scopus 로고    scopus 로고
    • International clinical recommendations on scar management
    • Overview of the available clinical literature by an international panel of experts providing evidence-based recommendations on the prevention and treatment of abnormal scarring, with a focus on the management of hypertrophic scars and keloids, •
    • Mustoe TA, Cooter RD, Gold MH, et al. International clinical recommendations on scar management. Plast Reconstr Surg 2002;110:560-71 • Overview of the available clinical literature by an international panel of experts providing evidence-based recommendations on the prevention and treatment of abnormal scarring, with a focus on the management of hypertrophic scars and keloids.
    • (2002) Plast Reconstr Surg , vol.110 , pp. 560-571
    • Mustoe, T.A.1    Cooter, R.D.2    Gold, M.H.3
  • 10
    • 33645114706 scopus 로고    scopus 로고
    • Emerging new drugs for scar reduction
    • Comprehensive review of existing treatments, emerging treatments, issues and challenges associated with the development of therapeutics for scar reduction, ••
    • Meier K, Nanney LB. Emerging new drugs for scar reduction. Expert Opin Emerg Drugs 2006;11:39-47 •• Comprehensive review of existing treatments, emerging treatments, issues and challenges associated with the development of therapeutics for scar reduction.
    • (2006) Expert Opin Emerg Drugs , vol.11 , pp. 39-47
    • Meier, K.1    Nanney, L.B.2
  • 11
    • 33747476374 scopus 로고    scopus 로고
    • Keloids and scars: A review of keloids and scars, their pathogenesis, risk factors, and management
    • Slemp AE, Kirschner RE. Keloids and scars: a review of keloids and scars, their pathogenesis, risk factors, and management. Curr Opin Pediatr 2006;18:396-402
    • (2006) Curr Opin Pediatr , vol.18 , pp. 396-402
    • Slemp, A.E.1    Kirschner, R.E.2
  • 12
    • 35448972539 scopus 로고    scopus 로고
    • A review of the biologic effects, clinical efficacy, and safety of silicone elastomer sheeting for hypertrophic and keloid scar treatment and management
    • Berman B, Perez OA, Konda S, et al. A review of the biologic effects, clinical efficacy, and safety of silicone elastomer sheeting for hypertrophic and keloid scar treatment and management. Dermatol Surg 2007;33:1291-302
    • (2007) Dermatol Surg , vol.33 , pp. 1291-1302
    • Berman, B.1    Perez, O.A.2    Konda, S.3
  • 13
    • 34848904509 scopus 로고    scopus 로고
    • Hypertrophic scar formation following burns and trauma: New approaches to treatment
    • Aarabi S, Longaker MT, Gurtner GC. Hypertrophic scar formation following burns and trauma: new approaches to treatment. PLoS Med 2007;4:e234
    • (2007) PLoS Med , vol.4
    • Aarabi, S.1    Longaker, M.T.2    Gurtner, G.C.3
  • 14
    • 33847241885 scopus 로고    scopus 로고
    • Review of over-the-counter topical scar treatment products
    • Shih R, Waltzman J, Evans GR. Review of over-the-counter topical scar treatment products. Plast Reconstr Surg 2007;119:1091-5
    • (2007) Plast Reconstr Surg , vol.119 , pp. 1091-1095
    • Shih, R.1    Waltzman, J.2    Evans, G.R.3
  • 15
    • 33645503090 scopus 로고    scopus 로고
    • Silicon gel sheeting for preventing and treating hypertrophic and keloid scars
    • CD003826
    • O'Brien L, Pandit A. Silicon gel sheeting for preventing and treating hypertrophic and keloid scars. Cochrane Database Syst Rev 2006;(1):CD003826
    • (2006) Cochrane Database Syst Rev , Issue.1
    • O'Brien, L.1    Pandit, A.2
  • 16
    • 53149149431 scopus 로고    scopus 로고
    • Reish RG, Eriksson E. Scars: a review of emerging and currently available therapies. Plast Reconstr Surg 2008;122:1068-78. Published online, doi:10.1097/PRS.0b013e318185d38f [doi];00006534-200810000-00010 [pii]
    • Reish RG, Eriksson E. Scars: a review of emerging and currently available therapies. Plast Reconstr Surg 2008;122:1068-78. Published online, doi:10.1097/PRS.0b013e318185d38f [doi];00006534-200810000-00010 [pii]
  • 17
    • 41149131166 scopus 로고    scopus 로고
    • Reish RG, Eriksson E. Scar treatments: preclinical and clinical studies. J Am Coll Surg 2008;206:719-30. Published online, doi:S1072-7515(07)01929-1 [pii];10.1016/j.jamcollsurg.2007.11.022 [doi]
    • Reish RG, Eriksson E. Scar treatments: preclinical and clinical studies. J Am Coll Surg 2008;206:719-30. Published online, doi:S1072-7515(07)01929-1 [pii];10.1016/j.jamcollsurg.2007.11.022 [doi]
  • 18
    • 54049151889 scopus 로고    scopus 로고
    • Occleston NL, O'Kane S, Goldspink N, Ferguson MW. New therapeutics for the prevention and reduction of scarring. Drug Discov Today 2008;13:973-81. Published online, doi:S1359-6446(08)00306-1 [pii];10.1016/j. drudis.2008.08.009 [doi] • Review of pharmaceutical approaches in development for scar improvement.
    • Occleston NL, O'Kane S, Goldspink N, Ferguson MW. New therapeutics for the prevention and reduction of scarring. Drug Discov Today 2008;13:973-81. Published online, doi:S1359-6446(08)00306-1 [pii];10.1016/j. drudis.2008.08.009 [doi] • Review of pharmaceutical approaches in development for scar improvement.
  • 19
    • 0013335233 scopus 로고
    • Marsupial models of scarless fetal wound healing. New York: Elsevier
    • Ferguson MWJ, Howarth GF. Marsupial models of scarless fetal wound healing. New York: Elsevier Science, 1991. p. 95-124
    • (1991) Science , pp. 95-124
    • Ferguson, M.W.J.1    Howarth, G.F.2
  • 20
    • 0025847137 scopus 로고
    • The extracellular matrix of lip wounds in fetal, neonatal and adult mice
    • Whitby DJ, Ferguson MW. The extracellular matrix of lip wounds in fetal, neonatal and adult mice. Development 1991;112:651-68
    • (1991) Development , vol.112 , pp. 651-668
    • Whitby, D.J.1    Ferguson, M.W.2
  • 21
    • 0028089015 scopus 로고
    • Adult skin wounds in the fetal environment heal with scar formation
    • Longaker MT, Whitby DJ, Ferguson MW, et al. Adult skin wounds in the fetal environment heal with scar formation. Ann Surg 1994;219:65-72
    • (1994) Ann Surg , vol.219 , pp. 65-72
    • Longaker, M.T.1    Whitby, D.J.2    Ferguson, M.W.3
  • 22
    • 0029049524 scopus 로고
    • Ontogeny of the skin and the transition from scar-free to scarring phenotype during wound healing in the pouch young of a marsupial, Monodelphis domestica
    • Armstrong JR, Ferguson MW. Ontogeny of the skin and the transition from scar-free to scarring phenotype during wound healing in the pouch young of a marsupial, Monodelphis domestica. Dev Biol 1995;169:242-60
    • (1995) Dev Biol , vol.169 , pp. 242-260
    • Armstrong, J.R.1    Ferguson, M.W.2
  • 23
    • 0029970366 scopus 로고    scopus 로고
    • Scar formation: The spectral nature of fetal and adult wound repair
    • Ferguson MW, Whitby DJ, Shah M, et al. Scar formation: the spectral nature of fetal and adult wound repair. Plast Reconstr Surg 1996;97:854-60
    • (1996) Plast Reconstr Surg , vol.97 , pp. 854-860
    • Ferguson, M.W.1    Whitby, D.J.2    Shah, M.3
  • 24
    • 2542505844 scopus 로고    scopus 로고
    • Scar-free healing: From embryonic mechanisms to adult therapeutic intervention
    • Comprehensive review of regenerative mechanisms of scar-free and scar forming healing, the discovery and translation of therapeutics for scar reduction in adults with a primary focus on TGF-β3, ••
    • Ferguson MW, O'Kane S. Scar-free healing: from embryonic mechanisms to adult therapeutic intervention. Philos Trans R Soc Lond B Biol Sci 2004;359:839-50 •• Comprehensive review of regenerative mechanisms of scar-free and scar forming healing, the discovery and translation of therapeutics for scar reduction in adults with a primary focus on TGF-β3.
    • (2004) Philos Trans R Soc Lond B Biol Sci , vol.359 , pp. 839-850
    • Ferguson, M.W.1    O'Kane, S.2
  • 25
    • 29344447472 scopus 로고    scopus 로고
    • Appendage regeneration in adult vertebrates and implications for regenerative medicine
    • Review of mechanisms of tissue regeneration in salamanders and the prospect of translation of this understanding in facilitating mammalian regeneration, •
    • Brockes JP, Kumar A. Appendage regeneration in adult vertebrates and implications for regenerative medicine. Science 2005;310:1919-23 • Review of mechanisms of tissue regeneration in salamanders and the prospect of translation of this understanding in facilitating mammalian regeneration.
    • (2005) Science , vol.310 , pp. 1919-1923
    • Brockes, J.P.1    Kumar, A.2
  • 26
    • 0025117567 scopus 로고    scopus 로고
    • Longaker MT, Whitby DJ, Adzick NS, et al. Studies in fetal wound healing, VI. Second and early third trimester fetal wounds demonstrate rapid collagen deposition without scar formation. J Pediatr Surg 1990;25:63-8. Published online, doi:S0022346890000203 [pii]
    • Longaker MT, Whitby DJ, Adzick NS, et al. Studies in fetal wound healing, VI. Second and early third trimester fetal wounds demonstrate rapid collagen deposition without scar formation. J Pediatr Surg 1990;25:63-8. Published online, doi:S0022346890000203 [pii]
  • 27
    • 0025946070 scopus 로고
    • Immunohistochemical localization of growth factors in fetal wound healing
    • Whitby DJ, Ferguson MW. Immunohistochemical localization of growth factors in fetal wound healing. Dev Biol 1991;147:207-15
    • (1991) Dev Biol , vol.147 , pp. 207-215
    • Whitby, D.J.1    Ferguson, M.W.2
  • 28
    • 68049119863 scopus 로고    scopus 로고
    • McCallion RL, Ferguson MWJ. Fetal wound healing and the development of antiscarring therapies for adult wound healing. 2nd edition. New York: Plenum Press, 1996. p. 561-600 •• Demonstration of the clinical potential for avotermin to provide an accelerated and permanent improvement in scarring in humans.
    • McCallion RL, Ferguson MWJ. Fetal wound healing and the development of antiscarring therapies for adult wound healing. 2nd edition. New York: Plenum Press, 1996. p. 561-600 •• Demonstration of the clinical potential for avotermin to provide an accelerated and permanent improvement in scarring in humans.
  • 29
    • 0031016797 scopus 로고    scopus 로고
    • Transforming growth factor betas and wound healing
    • O'Kane S, Ferguson MWJ. Transforming growth factor betas and wound healing. Int J Biochem Cell Biol 1997;29:63-78
    • (1997) Int J Biochem Cell Biol , vol.29 , pp. 63-78
    • O'Kane, S.1    Ferguson, M.W.J.2
  • 30
    • 46849101477 scopus 로고    scopus 로고
    • Prevention and reduction of scarring in the skin by transforming growth factor beta 3 (TGFb3): From laboratory discovery to clinical pharmaceutical
    • Occleston NL, Laverty HG, O'Kane S, Ferguson MWJ. Prevention and reduction of scarring in the skin by transforming growth factor beta 3 (TGFb3): from laboratory discovery to clinical pharmaceutical. J Biomater Sci Polym Ed 2008;19(8):1047-63
    • (2008) J Biomater Sci Polym Ed , vol.19 , Issue.8 , pp. 1047-1063
    • Occleston, N.L.1    Laverty, H.G.2    O'Kane, S.3    Ferguson, M.W.J.4
  • 31
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003;113:685-700
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 32
    • 0028986030 scopus 로고
    • Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring
    • Shah M, Foreman DM, Ferguson MW. Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring. J Cell Sci 1995;108(Pt 3):985-1002
    • (1995) J Cell Sci , vol.108 , Issue.PART 3 , pp. 985-1002
    • Shah, M.1    Foreman, D.M.2    Ferguson, M.W.3
  • 33
    • 0023473081 scopus 로고
    • Hepatic processing of transforming growth factor beta in the rat. Uptake, metabolism, and biliary excretion
    • Coffey RJ, Kost LJ, Lyons RM, et al. Hepatic processing of transforming growth factor beta in the rat. Uptake, metabolism, and biliary excretion. J Clin Invest 1987;80:750-7
    • (1987) J Clin Invest , vol.80 , pp. 750-757
    • Coffey, R.J.1    Kost, L.J.2    Lyons, R.M.3
  • 34
    • 0029064474 scopus 로고
    • Specific binding of endocrine transforming growth factor-beta 1 to vascular endothelium
    • Dickson K, Philip A, Warshawsky H, et al. Specific binding of endocrine transforming growth factor-beta 1 to vascular endothelium. J Clin Invest 1995;95:2539-54
    • (1995) J Clin Invest , vol.95 , pp. 2539-2554
    • Dickson, K.1    Philip, A.2    Warshawsky, H.3
  • 35
    • 0026090471 scopus 로고
    • An alpha 2-macroglobulin receptor-dependent mechanism for the plasma clearance of transforming growth factor-beta 1 in mice
    • LaMarre J, Hayes MA, Wollenberg GK, et al. An alpha 2-macroglobulin receptor-dependent mechanism for the plasma clearance of transforming growth factor-beta 1 in mice. J Clin Invest 1991;87:39-44
    • (1991) J Clin Invest , vol.87 , pp. 39-44
    • LaMarre, J.1    Hayes, M.A.2    Wollenberg, G.K.3
  • 36
    • 64049103218 scopus 로고    scopus 로고
    • Ferguson MW, Duncan J, Bond J, et al. Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies. Lancet 2009;373:1264-74. Published online, doi:S0140-6736(09)60322-6 [pii];10.1016/S0140-6736(09)60322-6 [doi]
    • Ferguson MW, Duncan J, Bond J, et al. Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies. Lancet 2009;373:1264-74. Published online, doi:S0140-6736(09)60322-6 [pii];10.1016/S0140-6736(09)60322-6 [doi]
  • 37
    • 33748769530 scopus 로고    scopus 로고
    • Visual analogue scale scoring and ranking: A suitable and sensitive method for assessing scar quality?
    • Duncan JA, Bond JS, Mason T, et al. Visual analogue scale scoring and ranking: a suitable and sensitive method for assessing scar quality? Plast Reconstr Surg 2006;118:909-18
    • (2006) Plast Reconstr Surg , vol.118 , pp. 909-918
    • Duncan, J.A.1    Bond, J.S.2    Mason, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.