Macrophage migration inhibitory factor induces contractile and mitochondria dysfunction by altering cytoskeleton network in the human heart

Critical Care Medicine

Volumn 41, Issue 7, 2013, Pages

  Preau, Sébastien ^a,b   Montaigne, David ^a   Modine, Thomas ^b   Fayad, George ^b   Koussa, Mohamed ^b   Tardivel, Meryem ^a   Durocher, Alain ^b   Saulnier, Fabienne ^b   Marechal, Xavier ^a   Neviere, Remi ^a  

^a UNIV LILLE   (France)

^b LILLE UNIVERSITY HOSPITAL   (France)

Author keywords

AMP activated protein kinase; contractile function; human heart; macrophage migration inhibitory factor; microtubule; mitochondria; oxygraphy

Indexed keywords

ACTIN; BETA TUBULIN; COLCHICINE; COMPOUND C; MACROPHAGE MIGRATION INHIBITION FACTOR; PACLITAXEL; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSKELETON; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTRON MICROSCOPY; HEART ATRIUM; HEART CONTRACTION; HEART MUSCLE CELL; HEART SURGERY; HUMAN; MAJOR CLINICAL STUDY; MICROTUBULE; MITOCHONDRIAL RESPIRATION; MYOCARDIAL DISEASE; POLYMERIZATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SARCOMERE;

AMP-ACTIVATED PROTEIN KINASES; COLCHICINE; CYTOSKELETON; HUMANS; LACTIC ACID; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MITOCHONDRIA, HEART; MUSCLE CONTRACTION; MYOCARDIUM; MYOCYTES, CARDIAC; NITRATES; NITRITES; PACLITAXEL; PYRAZOLES; PYRIMIDINES; TROPONIN I; TUBULIN MODULATORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84880572452     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31827c0d8c     Document Type: Article

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