Macrophage migration inhibitory factor induces cardiomyocyte apoptosis

Biochemical and Biophysical Research Communications

Volumn 371, Issue 2, 2008, Pages 298-303

  Dhanantwari, Preeta ^a   Nadaraj, Sumekala ^a,b   Kenessey, Agnes ^d   Chowdhury, Devyani ^a,c   Al Abed, Yousef ^d   Miller, Edmund J ^d   Ojamaa, Kaie ^a,d  

^a SCHNEIDER CHILDREN'S HOSPITAL   (United States)

^b SAINT PETER S UNIVERSITY HOSPITAL   (United States)

^c PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^d FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

Aardiomyocyte; Apoptosis; Bcl xL Bax; Caspase 3; Cytokines; ERK; ISO 1; JNK; Macrophage migration inhibitory factor; MIF; p38MAPK

Indexed keywords

CASPASE 3; MACROPHAGE MIGRATION INHIBITION FACTOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN BCL XL; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ANALYSIS; HEART MUSCLE CELL; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; IN SITU NICK-END LABELING; ISOXAZOLES; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MYOCYTES, CARDIAC; RATS; RATS, INBRED STRAINS; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 43049159522     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.04.070     Document Type: Article

References (37)

1. Bernhagen J., Calandra T., Mitchell R., Martin S., Tracey K., Voelter W., Manogue K., Cerami A., and Bucala R. MIF is a pituitary-derived cytokine that potentiates lethal endotoxemia. Nature 365 (1993) 756-759
2. Calandra T., Bernhagen J., Metz C., Spiegel L., Bacher M., Donnelly T., Ceraml A., and Bucala R. MIF as a glucocorticoid-induced modulator of cytokine production. Nature 377 (1995) 68-71
3. Beishuizen A., Thijs L.G., Haanen C., and Vermes I. Macrophage migration inhibitory factor and hypothalamo-pituitary-adrenal function during critical illness. J. Clin. Endocrinol. Metab. 86 (2001) 2811
4. Calandra T., Echtenacher B., Roy D., Pugin J., Metz C., Hultner L., Heumann D., Mannel D., Bucala R., and Glauser M. Protection from septic shock by neutralization of macrophage migration inhibitory factor. Nat. Med. 6 (2000) 164-170
5. Bozza M., Satoskar A.R., Lin G., Lu B., Humbles A.A., Gerard C., and David J.R. Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis. J. Exp. Med. 189 (1999) 341
6. Al-Abed Y., Dadideen D., Aljabari B., Valster A., Messmer D., Ochani M., Tanovic M., Ochani K., Bacher M., Nicoletti F., Metz C., Pavlov V.A., Miller E.J., and Tracey K.J. ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. J. Biol. Chem. 280 (2005) 36541-36544
7. Ochani M., Metz C.N., Alijabari B., Tanovic M., Pavlov V., Miller E.J., Tracey K.J., and Al-Abed Y. Macrophage migration inhibitory factor: pharmacological inhibition protects in endotoxemia and sepsis. Shock 21 (2004) 76
8. Sakuragi T., Lin X., Metz C., Ojamaa K., Kohn N., Al-Abed Y., and Miller E.J. Lung-derived macrophage migration inhibitory factor in sepsis induces cardio-circulatory depression. Surg. Infect. 8 (2007) 29-40
9. Lin X., Sakuragi T., Metz C.N., Ojamaa K., Skopicki H.A., Wang P., Al-Abed Y., and Miller E.J. Macrophage migration inhibitory factor within the alveolar spaces induces changes in the heart during late experimental sepsis. Shock 24 (2005) 556-563
10. Kapadia S.R., Oral H., Lee J., Nakano M., Taffet G.E., and Mann D.L. Hemodynamic regulation of tumor necrosis factor-alpha gene and protein expression in adult feline myocardium. Circ. Res. 81 (1997) 187-195
11. Garner L.B., Willis M.S., Carlson D.L., DiMaio J.M., White M.D., Shite D.J., Adams G.A., Horton J.W., and Giroir B.P. Macrophage migration inhibitory factor is a cardiac-derived myocardial depressant factor. Am. J. Physiol. 285 (2003) H2500-H2509
12. Takahashi M., Nishihira J., Shimpo M., Mizue Y., Ueno S., Mano H., Kobayashi E., Ikeda U., and Shimada K. Macrophage migration inhibitory factor as a redox-sensitive cytokine in cardiac myocytes. Cardiovasc. Res. 52 (2001) 438-445
13. Takahashi M., Nishihira J., Katsuki T., Kobayashi E., Ikeda U., and Shimada K. Elevation of plasma levels of macrophage migration inhibitory factor in patients with acute myocardial infarction. Am. J. Cardiol. 89 (2002) 248-249
14. Yu C.-M., Lau C.-P., Lai K.W.-H., Huang X.-R., Chen W.-H., and Lan H.Y. Elevation of plasma level of macrophage migration inhibitory factor in patients with acute myocardial infarction. Am. J. Cardiol. 88 (2001) 774-777
15. Medonca-Filho H., Gomes R., Campos L., Tura B., Nunes E., Gomes R., Bozza F., Bozza P., and Castro-Faria-Neto H. Circulating levels of macrophage migration inhibitory factor are associated with mild pulmonary dysfunction after cardiopulmonary bypass. Shock 22 6 (2004) 533-537
16. Gando S., Nishihira J., Kemmotsu O., Kobayashi S., Morimoto Y., Matsui Y., and Yasuda K. An increase in macrophage migration inhibitory factor release in patients with cardiopulmonary bypass surgery. Surg. Today 30 (2000) 689-694
17. Merchant S., Nadaraj S., Chowdhury D., Parnell V.A., Sison C., Miller E.J., and Ojamaa K. Macrophage migration inhibitory factor in pediatric patients undergoing surgery for congenital heart repair. Mol. Med. 14 (2008) 124-130
18. Ferdinandy P., Danial H., Ambrus I., Rothery R.A., and Schulz R. Peroxynitrite is a major contributor to cytokine-induced myocardial contractile failure. Circ. Res. 87 (2000) 241-247
19. Sun Y., Zhang J., Lu L., Chen S.S., Quin M.T., and Weber K.T. Aldosterone-induced inflammation in the rat heart. Role of oxidative stress. Am. J. Pathol. 161 (2002) 1773-1781
20. Wang W., Schulze C.J., Suarez-Pinzon W.L., Dyck J.R.B., Sawicki G., and Schulz R. Intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury. Circulation 106 (2002) 1543-1549
21. Sun M., Opavsky A., Stewart D.J., Rabinovitch M., Dawood F., Wen W.H., and Liu P.P. Temporal response and localization of integrins beta-1 and beta-2 in the heart following myocardial infarction. Regulation by cytokines. Circulation 107 (2003) 1046-1052
22. Nian M., Lee P., Khaper N., and Liu P. Inflammatory cytokines and postmyocardial infarction remodeling. Circ. Res. 94 (2004) 1543-1553
23. Calandra T., and Roger T. Macrophage migration inhibitory factor: a regulator of innate immunity. Nat. Rev. Immunol. 3 (2003) 791-800
24. Kenessey A., and Ojamaa K. Thyroid hormone stimulates protein synthesis in the cardiomyocyte by activating the Akt-mTOR and p70S6K pathways. J. Biol. Chem. 281 (2006) 20666-20672
25. Casciola-Rosen L., Rosen A., Petri M., and Schlissel M. Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: implications for coagulation events and antigenic spread in systemic lupus erythematosus. Proc. Natl. Acad. Sci. USA 93 (1996) 1624-1629
26. Baines C.P., and Molkentin J.D. STRESS signaling pathways that modulate cardiac myocyte apoptosis. J. Mol. Cell Cardiol. 38 (2005) 47-62
27. Rolfe M., McLeod L.E., Pratt P.F., and Proud C.G. Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2). Biochem. J. 388 (2005) 973-984
28. Frey N., and Olson E.N. Cardiac hypertrophy: the good, the bad, and the ugly. Annu. Rev. Physiol. 65 (2003) 45-79
29. Lue H., Kapurniotu A., Fingerle-Rowson G., Roger T., Leng L., Thiele M., Calandra T., Bucala R., and Bernhagen J. Rapid and transient activation of the ERK MAPK signaling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity. Cell. Signal. 18 (2006) 688-703
30. Fukuzawa J., Nishihira J., Hasebe N., Haneda T., Osaki J., Saito T., Nomura T., Fujino T., Wakamiya N., and Kikuchi K. Contribution of macrophage migration inhibitory factor to extracellular signal-regulated kinase activation by oxidative stress in cardiomyocytes. J. Biol. Chem. 277 (2002) 24889-24895
31. Dalby K.N., Morrice N., Caudwell F.B., Avruch J., and Chen P. Identification of regulatory phosphorylation site in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90RSK that are inducible by MAPK. J. Biol. Chem. 273 (1998) 1496-1505
32. Deak M., Clifton A.D., Lucocq L.M., and Alessi D.R. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/-38, and may mediate activation of CREB. EMBO J. 17 (1998) 4426-4441
33. Chagnon F., Metz C.N., Bucala R., and Lesur O. Endotoxin-induced myocardial dysfunction. Effects of macrophage migration inhibitory factor neutralization. Circ. Res. 96 (2005) 1095-1102
34. Ha T., Hua F., Grant D., Xia Y., Ma J., Gao X., Kelley J., Williams D.L., Kalbfleisch J., Browder I.W., Kao R.L., and Li D. Glucan phosphate attenuates cardiac dysfunction and inhibits cardiac MIF expression and apoptosis in septic mice. Am. J. Physiol. 291 (2006) H1910-H1918
35. Miller E.J., Li J., Leng L., McDonald C., Atsumi T., Bucala R., and Young L.H. Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischemic heart. Nature 451 (2008) 578-583
36. Shi X., Leng L., Wang T., Wang W., Du X., Li J., McDonald C., Chen Z., Murphy J.W., Lolis E., and Bucala R. CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity 25 (2006) 595-606
37. Aoki H., Kang P.M., Hampe J., Yoshimura K., Noma T., Matsuzaki M., and Izumo S. Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes. J. Biol. Chem. 277 (2002) 10244-10250